The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures

Modification of seizure activity by electrical stimulation: II. Motor seizure

1972 • 6,939 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Excitotoxity and the NMDA receptor

1987 • 1,053 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Modification of seizure activity by electrical stimulation: I. after-discharge threshold

1972 • 735 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Kindling

1978 • 482 citations

NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling

1987 • 401 citations

Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine

1987 • 380 citations

Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy

1987 • 375 citations

3H-labeled MK-801 binding to the excitatory amino acid receptor complex from rat brain is enhanced by glycine.

1987 • 335 citations

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity

1986 • 311 citations

Evidence implicating substantia nigra in regulation of kindled seizure threshold

1984 • 301 citations

Receptors for the excitatory amino acids in the mammalian central nervous system

1983 • 292 citations

Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by d(−)aminophosphonovalerate

1987 • 269 citations

Development of a New Pharmacological Seizure Model: Effects of Anticonvulsants on Cortical‐and Amygdala‐Kindled Seizures in the Rat

1980 • 261 citations

CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.

1987 • 231 citations

Receptors, ion channels and synaptic potentials underlying the integrative actions of excitatory amino acids

1987 • 211 citations

A selective N-methyl-d-aspartate antagonist depresses epileptiform activity in rat hippocampal slices

1985 • 205 citations

MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

1987 • 194 citations

The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists

1983 • 180 citations

Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: Effects of intranigral 2-amino-7-phosphonoheptanoate and n-methyl-d-aspartate

1986 • 143 citations

Pharmacological Prophylaxis in the Kindling Model of Epilepsy

1977 • 133 citations

Facilitation of kindling by prior induction of long-term potentiation in the perforant path

1987 • 123 citations

N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus

1986 • 122 citations

Bursting in human epileptogenic neocortex is depressed by an antagonist

1987 • 116 citations

Role of excitatory amino acid transmission in the genesis of seizures elicited from the deep prepiriform cortex

1986 • 111 citations

Retardation of amygdala kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: Evidence for the summation of excitatory mechanisms in kindling

1988 • 111 citations

Neurotransmitter and neuromodulator function in the kindled seizure and state

1982 • 110 citations

Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus

1985 • 95 citations

Post-activation potentiation and the kindling phenomenon

1975 • 92 citations

N-methylaspartate receptors mediate epileptiform activity evoked in some, but not all, conditions in rat neocortical slices

1986 • 85 citations

The Substantia Nigra is an Important Site for the Containment of Seizure Generalization in the Kindling Model of Epilepsy

1987 • 79 citations

Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists

1984 • 57 citations

Cumulative after-discharge as the principal factor in the acquisition of kindled seizures

1981 • 49 citations

The role of substantia nigra in the development of kindling: pharmacologic and lesion studies

1987 • 44 citations

The convulsant and anticonvulsant effects of phencyclidine (PCP) and PCP analogues in the rat

1986 • 40 citations

Phencyclidine raises kindled seizure thresholds

1982 • 31 citations

The anticonvulsant and behavioral effects of phencyclidine and ketamine following chronic treatment in rats

1986 • 21 citations

Drug May Protect Brains of Heart Attack Victims

1987 • 13 citations