Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Statistical principles in experimental design.

1962 • 27,228 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.

1992 • 5,156 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

Time-Dependent Processes in Memory Storage

1966 • 1,452 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

On the role of the hippocampus in learning and memory in the rat

1993 • 1,116 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

The changing scene of neurotrophic factors

1991 • 827 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

A BDNF autocrine loop in adult sensory neurons prevents cell death

1995 • 743 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

1992 • 564 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Body and Brain: A Trophic Theory of Neural Connections

1992 • 426 citations

Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment

1992 • 386 citations

Emotion and the amygdala.

1992 • 345 citations

The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus

1993 • 313 citations

Physiological identification and analysis of dentate granule cell responses to stimulation of the medial and lateral perforant pathways in the rat

1977 • 283 citations

Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors

1994 • 210 citations

A computer program for selection of oligonucleotide primers for polymerase chain reactions

1990 • 195 citations

Synaptic plasticity: hippocampal LTP

1995 • 173 citations

Effects of Sequence of Thioated Oligonucleotides on Cultured Human Mammary Epithelial Cells

1993 • 137 citations

Brain-derived neurotrophic factor is induced as an immediate early gene following N-methyl-d-aspartate receptor activation

1993 • 122 citations

A neuronal mechanism for sensory gating during locomotion in a vertebrate

1988 • 119 citations

Involvement of the amygdaloid complex in neuromodulatory influences on memory storage

1990 • 119 citations

The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression

1996 • 108 citations

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex

1991 • 106 citations

Differential Effects of MK-801 on Brain-Derived Neurotrophic Factor mRNA Levels in Different Regions of the Rat Brain

1993 • 99 citations

Role of NMDA receptors in memory

1991 • 96 citations

Pre- and posttraining infusion of N-methyl-D-aspartate receptor antagonists into the amygdala impair memory in an inhibitory avoidance task.

1994 • 90 citations

Hippocampal CRF, NE, and NMDA system interactions in memory processing in the rat

1993 • 88 citations

Pre- and posttraining infusion of N-methyl-D-aspartate receptor antagonists into the amygdala impair memory in an inhibitory avoidance task.

1994 • 79 citations

Role of angiotensin II and AT1 receptors in hippocampal LTP

1993 • 77 citations

Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones

1993 • 69 citations

Activation of NMDA receptors increases brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampal formation

1993 • 68 citations

The gene encoding hypoxanthine-guanine phosphoribosyltransferase as target for mutational analysis: PCR cloning and sequencing of the cDNA from the rat

1992 • 53 citations

Amygdaloid complex modulates neurotransmission from the entorhinal cortex to the dentate gyrus of the rat

1984 • 52 citations

Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 mRNAs in adult rat brain after intrahippocampal injection of quinolinic acid

1994 • 41 citations

Neurotrophic factors in memory disorders

1994 • 26 citations

Enhanced hippocampal corticotropin-releasing factor gene expression associated with memory consolidation and memory storage in rats.

1996 • 19 citations

Nicotine Blocks Angiotensin II Inhibition of LTP in the Dentate Gyrus

1996 • 17 citations

Comparative studies of the neurotoxicity of MPTP in rats of different ages.

1992 • 8 citations