The role of immediate early genes in the stabilization of long-term potentiation

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation

1987 • 1,975 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure

1987 • 1,771 citations

DHAM-BMSC matrix promotes axonal regeneration and functional recovery after spinal cord injury in adult rats.

2009 • 1,710 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

1987 • 888 citations

DNA binding activities of three murine Jun proteins: Stimulation by Fos

1988 • 850 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus

1989 • 612 citations

Heterosynaptic depression: a postsynaptic correlate of long-term potentiation

1977 • 606 citations

Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials

1987 • 585 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus

1987 • 579 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Long-term potentiation phenomena in the rat limbic forebrain

1983 • 562 citations

Regulation of Proenkephalin by Fos and Jun

1989 • 546 citations

Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice

1984 • 531 citations

Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats

1984 • 508 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus

1975 • 501 citations

Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines

1985 • 478 citations

Brief bursts of high-frequency stimulation produce two types of structural change in rat hippocampus.

1980 • 474 citations

Induction of protooncogene c-jun by serum growth factors.

1988 • 438 citations

Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat

1988 • 426 citations

Convulsant-induced increase in transcription factor messenger RNAs in rat brain.

1988 • 377 citations

Long-term potentiation as a candidate mnemonic device

1984 • 375 citations

Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons

1990 • 355 citations

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

1985 • 317 citations

NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the l-arginine-nitric oxide pathway

1991 • 301 citations

Hippocampal long‐term potentiation is induced by pairing single afferent volleys with intracellular^ injected depolarizing current pulses

1986 • 284 citations

Synaptic correlates of associative potentiation/depression: an ultrastructural study in the hippocampus

1983 • 278 citations

Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization

1989 • 275 citations

Memories of fos

1987 • 253 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Long-term potentiation: from biophysics to behavior

1988 • 238 citations

Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation

1989 • 236 citations

IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation

1991 • 212 citations

A selective increase in phosphorylation of protein F1, a protein kinase C substrate, directly related to three day growth of long term synaptic enhancement

1985 • 200 citations

In search of cellular mechanisms of memory

1989 • 198 citations

Asymmetric relationships between homosynaptic long-term potentiation and heterosynaptic long-term depression

1983 • 196 citations

Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized rats

1989 • 185 citations

Correlation between the induction of an immediate early gene,zif/268, and long-term potentiation in the dentate gyrus

1992 • 168 citations

Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following recurrent seizures

1987 • 168 citations

Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: Pharmacological characterization

1990 • 165 citations

Structure of the NGFI-A gene and detection of upstream sequences responsible for its transcriptional induction by nerve growth factor.

1989 • 164 citations

Effects of early experience on c-fos gene expression in the chick forebrain

1991 • 157 citations

Photic induction of Fos protein in the suprachiasmatic nucleus is inhibited by the NMDA receptor antagonist MK-801

1991 • 156 citations

Ca²⁺/calmodulin‐dependent phosphorylation of elongation factor 2

1987 • 150 citations

Learning‐induced Increase of Immediate Early Gene Messenger RNA in the Chick Forebrain

1991 • 141 citations

MK-801 induces c-fos protein in thalamic and neocortical neurons of rat brain

1990 • 126 citations

c-fos expression and (14C) 2-deoxyglucose uptake in the caudal cerebellum of the rat during motor/sensory cortex stimulation

1989 • 121 citations

Electrical stimulation in vivo increases the expression of proenkephalin mRNA and decreases the expression of prodynorphin mRNA in rat hippocampal granule cells.

1988 • 117 citations

Induction of Fos-like immunoreactivity and the maintenance of long-term potentiation in the dentate gyrus of unanesthetized rats

1990 • 111 citations

Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

1989 • 100 citations

Activation of immediate early genes after acute stress

1991 • 99 citations

Fos-Jun and the primary genomic response in the nervous system

1990 • 98 citations

Onset Characteristics of Long‐Term Potentiation in the Guinea‐Pig Hippocampal CA1 Region in Vitro

1989 • 93 citations

High-frequency discharge of dentate granule cells, but not long-term potentiation, induces c-fos protein

1988 • 93 citations

NMDA‐dependent heterosynaptic long‐term depression in the dentate gyrus of anaesthetized rats

1992 • 89 citations

Unusual Early Cretaceous birds from Spain

1988 • 87 citations

Accumulation of c-fos mRNA in rat hippocampus during acquisition of a brightness discrimination

1990 • 85 citations

High basal expression of the immediate early gene in cortical layers IV and VI, in CA1 and in the corpus striatum - an in situ hybridization study

1991 • 84 citations

The KROX-24 protein, a new transcription regulating factor: Expression in the rat central nervous system following afferent somatosensory stimulation

1990 • 83 citations

A critical level of protein synthesis is required for long‐term potentiation

1987 • 83 citations

Presence of c-fos-like immunoreactivity in the adult rat brain

1987 • 82 citations

Heterosynaptic long-term depression is facilitated by blockade of inhibition in area CA1 of the hippocampus

1991 • 69 citations

Localization of the NGFI-A protein in the rat brain

1990 • 55 citations

Tumor Promoter-Inducible Genes Are Differentially Expressed in the Developing Mouse

1988 • 53 citations

MK801 induces c-fos protein in thalamic and neocortical neurons of rat brain

1990 • 51 citations

Trans-synaptic regulation of tyrosine hydroxylase activity in a developing mouse sympathetic ganglion: Effects of nerve growth factor (NGF), NGF-antiserum and pempidine

1973 • 43 citations

Tumor promoter-inducible genes are differentially expressed in the developing mouse.

1988 • 42 citations

Phosphorylation of elongation factor 2: a key mechanism regulating gene expression in vertebrates.

1990 • 41 citations

Increases in mRNA for cytoskeletal proteins in the denervated neuropil of the dentate gyrus: an in situ hybridization study using riboprobes for β-actin and β-tubulin

1990 • 34 citations

Rolipram induces c-fos protein-like immunoreactivity in ependymal and glial-like cells in adult rat brain

1989 • 26 citations

Temporally defined induction of c-fos in the rat pineal

1990 • 25 citations

Effects of unilateral cortex lesions on gene expression of rat cortical cholecystokinin neurons

1991 • 25 citations

Transient increase of raf protein kinase-like immunoreactivity in the rat dentate gyrus during long-term potentiation

1990 • 24 citations