Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

The Energy Landscapes and Motions of Proteins

1991 • 3,100 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

The two-state model of receptor activation

1995 • 492 citations

Molecular mechanism of vectorial proton translocation by bacteriorhodopsin

2000 • 436 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

Agonist-induced conformational changes in the G-protein-coupling domain of the β ₂ adrenergic receptor

2001 • 311 citations

Fluorescent Labeling of Purified β2 Adrenergic Receptor

1995 • 271 citations

A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.

1994 • 226 citations

μ-Opioid Receptor-Stimulated Guanosine-5′-O-(γ-thio)-triphosphate Binding in Rat Thalamus and Cultured Cell Lines: Signal Transduction Mechanisms Underlying Agonist Efficacy

1997 • 202 citations

A 10-GHz frequency-domain fluorometer

1990 • 198 citations

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1996 • 188 citations

Shaker potassium channel gating. I: Transitions near the open state.

1994 • 187 citations

Photoactivated Conformational Changes in Rhodopsin: A Time-Resolved Spin Label Study

1993 • 140 citations

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.

1991 • 131 citations

Agonist-specific receptor conformations

1997 • 86 citations

Discussion

1999 • 67 citations

The Stability of the Agonist β₂-Adrenergic Receptor-G_sComplex: Evidence for Agonist-Specific States

1997 • 61 citations

The role of cytosolic and membrane factors in processing of the human beta-2 adrenergic receptor following translocation and glycosylation in a cell-free system.

1990 • 55 citations

Agonist-specific receptor conformations

1997 • 48 citations

Fluorescent Biomolecules: Methodologies And Applications

2012 • 38 citations

Partial agonist effects on the interaction between the atrial muscarinic receptor and the inhibitory guanine nucleotide-binding protein in a reconstituted system.

1990 • 32 citations

Is the R and R* dichotomy real?

1997 • 22 citations

Is the R and R∗ dichotomy real?

1997 • 20 citations

Protein Dynamics: Fluorescence Lifetime Distributions

1989 • 6 citations