Sequential Binding of Agonists to the β2 Adrenoceptor

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

G Protein-coupled Receptors

1998 • 1,292 citations

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

2002 • 1,070 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

1996 • 536 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

Inverse, protean, and ligand‐selective agonism: matters of receptor conformation

2001 • 403 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

Agonists induce conformational changes in transmembrane domains III and VI of the beta 2 adrenoceptor

1997 • 378 citations

Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor

2001 • 361 citations

Ligand-selective receptor conformations revisited: the promise and the problem

2003 • 319 citations

Agonist-induced conformational changes in the G-protein-coupling domain of the β ₂ adrenergic receptor

2001 • 311 citations

Structural Instability of a Constitutively Active G Protein-coupled Receptor

1997 • 285 citations

Specific Tryptophan UV-Absorbance Changes Are Probes of the Transition of Rhodopsin to Its Active State

1996 • 226 citations

The Cubic Ternary Complex Receptor-Occupancy Model III. Resurrecting Efficacy

1996 • 203 citations

Mutation of a Highly Conserved Aspartic Acid in the β₂Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6

1999 • 203 citations

Lessons from constitutively active mutants of G protein-coupled receptors

2002 • 192 citations

Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor.

1996 • 190 citations

Similar Structures and Shared Switch Mechanisms of the β2-Adrenoceptor and the Parathyroid Hormone Receptor

1999 • 186 citations

The Forgotten Serine

2000 • 186 citations

Constitutive Activation of the β2 Adrenergic Receptor Alters the Orientation of Its Sixth Membrane-spanning Segment

1997 • 186 citations

Conformational Changes in Rhodopsin

1999 • 168 citations

Amino and Carboxyl Terminal Modifications to Facilitate the Production and Purification of a G Protein-Coupled Receptor

1995 • 160 citations

Agonist-induced Conformational Changes at the Cytoplasmic Side of Transmembrane Segment 6 in the β2 Adrenergic Receptor Mapped by Site-selective Fluorescent Labeling

2001 • 140 citations

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.

1991 • 131 citations

The Neurokinin A Receptor Activates Calcium and cAMP Responses through Distinct Conformational States

2001 • 129 citations

Structure and Function in Rhodopsin: Mapping Light-Dependent Changes in Distance between Residue 316 in Helix 8 and Residues in the Sequence 60−75, Covering the Cytoplasmic End of Helices TM1 and TM2 and Their Connection Loop CL1

2001 • 100 citations

Structural Features and Light-Dependent Changes in the Sequence 306−322 Extending from Helix VII to the Palmitoylation Sites in Rhodopsin: A Site-Directed Spin-Labeling Study^,

1999 • 98 citations

Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor

2002 • 87 citations

Structural Features and Light-Dependent Changes in the Sequence 59−75 Connecting Helices I and II in Rhodopsin: A Site-Directed Spin-Labeling Study^,

1999 • 84 citations

Conformational Changes That Occur during M3Muscarinic Acetylcholine Receptor Activation Probed by the Use of an in Situ Disulfide Cross-linking Strategy

2002 • 81 citations

Functional Immobilization of a Ligand-Activated G-Protein-Coupled Receptor

2002 • 60 citations

The role of cytosolic and membrane factors in processing of the human beta-2 adrenergic receptor following translocation and glycosylation in a cell-free system.

1990 • 55 citations