Differential Involvement of Gα12 and Gα13 in Receptor-mediated Stress Fiber Formation

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

G proteins

1992 • 871 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Defective platelet activation in Gαq-deficient mice

1997 • 566 citations

Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C

1995 • 488 citations

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

1990 • 463 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.

1994 • 441 citations

Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα ₁₃ Deficiency

1997 • 340 citations

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.

1996 • 312 citations

Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction

1992 • 290 citations

Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.

1991 • 278 citations

Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.

1992 • 277 citations

The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho

1998 • 265 citations

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.

1991 • 263 citations

The rho gene product expressed in E. Coli is a substrate of botulinum ADP-ribosyltransferase C3

1989 • 252 citations

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.

1991 • 250 citations

Embryonic cardiomyocyte hypoplasia and craniofacial defects in Galpha q/Galpha 11-mutant mice

1998 • 238 citations

Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

1996 • 220 citations

Regulation of phospholipase C by G proteins

1992 • 205 citations

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

1995 • 178 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

G alpha 13 stimulates Na-H exchange.

1994 • 175 citations

Gα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways

1996 • 171 citations

Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.

1993 • 168 citations

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

1992 • 148 citations

Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants.

1992 • 129 citations

Protein kinase C-dependent and -independent activation of Na+/H+ exchanger by G alpha 12 class of G proteins.

1994 • 109 citations

G Protein Heterotrimer Gα13β1γ3 Couples the Angiotensin AT1A Receptor to Increases in Cytoplasmic Ca2+ in Rat Portal Vein Myocytes

1997 • 83 citations

Gα12 Differentially Regulates Na+-H+ Exchanger Isoforms

1996 • 81 citations

[6] Gi assays in transfected cells

1994 • 63 citations