Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

Pharmacologic Analysis of Drug Receptor Interaction

1988 • 936 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

5-Hydroxytryptamine receptors

2001 • 693 citations

Agonist-receptor efficacy II: agonist trafficking of receptor signals

1995 • 637 citations

5‐Hydroxytryptamine Receptors

1993 • 524 citations

The two-state model of receptor activation

1995 • 492 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

Diversity and Selectivity of Receptor-G Protein Interaction

1996 • 365 citations

P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure

1995 • 323 citations

Fluorescent Labeling of Purified β2 Adrenergic Receptor

1995 • 271 citations

The classification of seven transmembrane receptors in recombinant expression systems.

1996 • 271 citations

Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.

1994 • 243 citations

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

1992 • 232 citations

Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis.

1990 • 215 citations

A three-state receptor model of agonist action

1997 • 192 citations

The human thyrotropin receptor activates G-proteins Gs and Gq/11.

1994 • 190 citations

Thyrotropin activates both the cyclic AMP and the PIP2casades in CHO cells expressing the human cDNA of TSH receptor

1990 • 184 citations

Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.

1988 • 145 citations

Do classical hallucinogens act as 5-HT2 agonists or antagonists?

1990 • 137 citations

Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems.

1994 • 130 citations

Selective Activation of Inhibitory G-Protein .alpha.-Subunits by Partial Agonists of the Human 5-HT1A Receptor

1994 • 92 citations

A transduction pathway associated with receptors coupled to the inhibitory guanine nucleotide binding protein Gi that amplifies ATP-mediated arachidonic acid release.

1991 • 84 citations

Signal transduction by a 5-HT2 receptor: a mechanistic hypothesis from molecular dynamics simulations of the three-dimensional model of the receptor complexed to ligands

1993 • 84 citations

The gonadotrophin-releasing hormone receptor of alpha T3-1 pituitary cells regulates cellular levels of both of the phosphoinositidase C-linked G proteins, Gq alpha and G11 alpha, equally.

1994 • 75 citations

Contribution of a helix 5 locus to selectivity of hallucinogenic and nonhallucinogenic ligands for the human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors: direct and indirect effects on ligand affinity mediated by the same locus.

1996 • 74 citations

Receptor subtype and density determine the coupling repertoire of the 5-ht2 receptor subfamily

1996 • 64 citations

Characterization of a 5‐HT_1B receptor on CHO cells: functional responses in the absence of radioligand binding

1996 • 64 citations

5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms.

1994 • 63 citations

Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes.

1994 • 63 citations

(+)Lysergic acid diethylamide, but not its nonhallucinogenic congeners, is a potent serotonin 5HT1C receptor agonist.

1991 • 62 citations

The Stability of the Agonist β₂-Adrenergic Receptor-G_sComplex: Evidence for Agonist-Specific States

1997 • 61 citations

Serotonin 5‐HT_2C Receptor Stimulates Cyclic GMP Formation in Choroid Plexus

1995 • 61 citations

5-hydroxytryptamine2C receptor activation inhibits 5-hydroxytryptamine1B-like receptor function via arachidonic acid metabolism.

1996 • 55 citations

The human muscarinic M1 acetylcholine receptor, when expressed in CHO cells, activates and downregulates both G_qα and G₁₁α equally and non‐selectively

1993 • 41 citations