Requirement for Rho-mediated Myosin Light Chain Phosphorylation in Thrombin-stimulated Cell Rounding and Its Dissociation from Mitogenesis

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

The Function of Myosin and Myosin Light Chain Kinase Phosphorylation in Smooth Muscle

1985 • 1,052 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Identification of a Putative Target for Rho as the Serine-Threonine Kinase Protein Kinase N

1996 • 417 citations

Cellular consequences of thrombin-receptor activation

1996 • 341 citations

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

1988 • 337 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Norepinephrine and GTP-γ-S increase myofilament Ca2+ sensitivity in α-toxin permeabilized arterial smooth muscle

1988 • 303 citations

A bent monomeric conformation of myosin from smooth muscle.

1982 • 283 citations

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

1992 • 248 citations

Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

1992 • 245 citations

Ras-related GTPases and the cytoskeleton.

1992 • 232 citations

G protein‐coupled receptors and signaling pathways regulating growth responses ¹

1996 • 221 citations

Translocation of rhoA Associated with Ca2+ Sensitization of Smooth Muscle

1997 • 218 citations

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling

1993 • 205 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca²⁺ Signaling and Rho

1996 • 198 citations

Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.

1994 • 188 citations

Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers.

1992 • 188 citations

Involvement of rho in GTPγS‐induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity

1995 • 187 citations

alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.

1994 • 186 citations

Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.

1992 • 185 citations

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

1995 • 178 citations

Substrate for botulinum ADP-ribosyltransferase, Gb, has an amino acid sequence homologous to a putative rho gene product.

1988 • 178 citations

Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.

1994 • 177 citations

Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP-dependent protein kinase and by cyclic GMP-dependent protein kinase.

1984 • 176 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Differential activation of p44mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist

1993 • 163 citations

Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac

1996 • 152 citations

Regulation of permeabilized endothelial cell retraction by myosin phosphorylation

1991 • 149 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

1996 • 137 citations

Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability

1996 • 134 citations

The Cloned Thrombin Receptor Is Necessary and Sufficient for Activation of Mitogen-activated Protein Kinase and Mitogenesis in Mouse Lung Fibroblasts

1996 • 127 citations

Thrombin Receptor Activation Stimulates Astrocyte Proliferation and Reversal of Stellation by Distinct Pathways: Involvement of Tyrosine Phosphorylation

1995 • 119 citations

Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.

1993 • 106 citations

G12 Requirement for Thrombin-stimulated Gene Expression and DNA Synthesis in 1321N1 Astrocytoma Cells

1995 • 96 citations

Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. Comparison of thrombin and carbachol action in cells expressing M1 muscarinic acetylcholine receptors.

1990 • 89 citations

Dissociation of protein kinase C redistribution from the phosphorylation of its substrates

1991 • 87 citations

alpha-Thrombin-induced early mitogenic signalling events and G0 to S-phase transition of fibroblasts require continual external stimulation.

1985 • 83 citations

Agonist-induced desensitization of muscarinic receptor-mediated calcium efflux without concomitant desensitization of phosphoinositide hydrolysis.

1985 • 81 citations

The signal transduction induced by thrombin in human platelets

1990 • 78 citations

Coupling of the thrombin receptor to G12 may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells.

1996 • 76 citations

An increase or a decrease in myosin II phosphorylation inhibits macrophage motility.

1991 • 76 citations

A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells.

1993 • 71 citations

Biphasic Increase in c-jun mRNA Is Required for Induction of AP-1-Mediated Gene Transcription: Differential Effects of Muscarinic and Thrombin Receptor Activation

1992 • 71 citations

Activation of actin-activated ATPase in smooth muscle by phosphorylation of myosin light chain with protease-activated kinase I.

1984 • 48 citations

Thrombin and trypsin act at the same site to stimulate phosphoinositide hydrolysis and calcium mobilization.

1989 • 41 citations

Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells

1996 • 34 citations

A Subset of Protein Kinase C Phosphorylation Sites on the Myosin II Regulatory Light Chain Inhibits Phosphorylation by Myosin Light Chain Kinase

1997 • 29 citations

ADP‐ribosylation by Clostridium botulinum C3 exoenzyme increases steady‐state GTPase activities of recombinant rhoA and rhoB proteins

1992 • 29 citations

Myosin light chain phosphorylation does not increase during yeast phagocytosis by macrophages

1993 • 27 citations

Rapid heterologous desensitization of muscarinic and thrombin receptor-mediated phospholipase D activation.

1994 • 26 citations

Identification of a B2-bradykinin receptor linked to phospholipase C and inhibition of dopamine stimulated cyclic AMP accumulation in the human astrocytoma cell line D384

1992 • 23 citations

Thrombin Receptor Agonist Peptide Induction of Mitogenesis in CCL39 Cells

1993 • 19 citations

A 22 kDa ras‐related G‐protein is the substrate for an ADP‐ribosyltransferase from Clostridium botulinum

1988 • 10 citations