p300/CBP proteins: HATs for transcriptional bridges and scaffolds

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

Structure and ligand of a histone acetyltransferase bromodomain

1999 • 1,625 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

1995 • 1,197 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

1998 • 984 citations

Coactivator and corepressor complexes in nuclear receptor function

1999 • 909 citations

Stabilization of wild-type p53 by hypoxia-inducible factor 1α

1998 • 818 citations

Structure and Function of a Human TAF _II 250 Double Bromodomain Module

2000 • 808 citations

An essential role for p300/CBP in the cellular response to hypoxia

1996 • 780 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

1996 • 756 citations

Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma

1994 • 748 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

1997 • 725 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Regulation of E2F1 activity by acetylation

2000 • 654 citations

Transcription Factor-Specific Requirements for Coactivators and Their Acetyltransferase Functions

1998 • 639 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Mutations truncating the EP300 acetylase in human cancers

2000 • 590 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

The transcriptional role of PML and the nuclear body

2000 • 574 citations

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

1998 • 568 citations

The Enhanceosome and Transcriptional Synergy

1998 • 545 citations

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1995 • 534 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Histone acetylation: chromatin in action

1997 • 475 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.

1996 • 453 citations

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

2000 • 424 citations

CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

1998 • 420 citations

Differential Roles of p300 and PCAF Acetyltransferases in Muscle Differentiation

1997 • 419 citations

p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

1998 • 415 citations

HIV-1 Tat transcriptional activity is regulated by acetylation

1999 • 411 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

Regulation of Histone Acetyltransferases p300 and PCAF by the bHLH Protein Twist and Adenoviral Oncoprotein E1A

1999 • 372 citations

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

1998 • 369 citations

Targeting Chromatin Disruption: Transcription Regulators that Acetylate Histones

1996 • 369 citations

Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation.

1996 • 361 citations

Acetylation of MyoD Directed by PCAF Is Necessary for the Execution of the Muscle Program

1999 • 351 citations

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

1998 • 345 citations

A Viral Mechanism for Inhibition of p300 and PCAF Acetyltransferase Activity

1999 • 343 citations

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

1995 • 338 citations

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

1998 • 337 citations

Histone acetylation and control of gene expression

1991 • 331 citations

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation

1998 • 330 citations

Yeast histone H4 N-terminal sequence is required for promoter activation in vivo

1991 • 330 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

1998 • 321 citations

Human p300 Protein Is a Coactivator for the Transcription Factor MyoD

1996 • 319 citations

Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase

1998 • 318 citations

Modulation of Chromatin Folding by Histone Acetylation

1995 • 311 citations

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

1992 • 302 citations

p300 and CBP: Partners for life and death

1999 • 299 citations

Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A

1998 • 298 citations

p300 gene alterations in colorectal and gastric carcinomas.

1996 • 293 citations

Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein–Taybi syndrome

1997 • 289 citations

Signal-specific co-activator domain requirements for Pit-1 activation

1998 • 284 citations

p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription

1997 • 281 citations

Acetylation control of the retinoblastoma tumour-suppressor protein

2001 • 280 citations

Acetylation Regulates Transcription Factor Activity at Multiple Levels

2000 • 268 citations

The acetyltransferase activity of CBP stimulates transcription

1998 • 265 citations

Adenoviral E1A-Associated Protein p300 Is Involved in Acute Myeloid Leukemia With t(11; 22)(q23; q13)

1997 • 264 citations

In vivo studies on the dynamics of histone-DNA interaction: evidence for nucleosome dissolution during replication and transcription and a low level of dissolution independent of both

1990 • 261 citations

The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

1996 • 254 citations

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

1990 • 251 citations

Reversible Oligonucleosome Self-Association: Dependence on Divalent Cations and Core Histone Tail Domains

1996 • 250 citations

Association of p300 and CBP with Simian Virus 40 Large T Antigen

1996 • 246 citations

DNA tumor virus transforming proteins and the cell cycle

1993 • 242 citations

Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression

1997 • 236 citations

Transcriptional control: Versatile molecular glue

1996 • 231 citations

E2F Family Members Are Differentially Regulated by Reversible Acetylation

2000 • 230 citations

Eukaryotic RNA polymerase II binds to nucleosome cores from transcribed genes

1983 • 224 citations

A Novel Cofactor for p300 that Regulates the p53 Response

1999 • 218 citations

p300-Mediated acetylation facilitates the transfer of histone H2A–H2B dimers from nucleosomes to a histone chaperone

2000 • 209 citations

Acetylation of TAFI68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

2001 • 200 citations

MAP Kinase-Dependent Transcriptional Coactivation by Elk-1 and Its Cofactor CBP

1996 • 196 citations

Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo.

1992 • 186 citations

XenopusNF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from theXenopus hsp70promoterin vivo

1998 • 186 citations

A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans

1998 • 176 citations

Acetylation of importin-α nuclear import factors by CBP/p300

2000 • 173 citations

Functional Interaction between Nucleosome Assembly Proteins and p300/CREB-Binding Protein Family Coactivators

2000 • 151 citations

Adenovirus E1A targets key regulators of cell proliferation.

1992 • 148 citations

The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies

1997 • 147 citations

Regulation of E2F transcription by cyclin E–Cdk2 kinase mediated through p300/CBP co-activators

2000 • 144 citations

Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin

1998 • 139 citations

Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP

2000 • 128 citations

c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300

2000 • 127 citations

Phosphorylation by p44 MAP Kinase/ERK1 Stimulates CBP Histone Acetyl Transferase Activity in Vitro

1999 • 127 citations

Absence of Gcn5 HAT Activity Defines a Novel State in the Opening of Chromatin at the PHO5 Promoter in Yeast

1998 • 121 citations

Functional interplay between p53 and E2F through co-activator p300

1998 • 112 citations

Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-β enhanceosome in vitro

1998 • 110 citations

Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.

1991 • 109 citations

Exchange of histones H1, H2A, and H2B in vivo

1985 • 104 citations

p300 Interacts with the Nuclear Proto-Oncoprotein SYT as Part of the Active Control of Cell Adhesion

2000 • 101 citations

Nerve Growth Factor Up-regulates the Transcriptional Activity of CBP through Activation of the p42/p44MAPK Cascade

1998 • 97 citations

Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.

1995 • 94 citations

Transcription of chromatin: these are complex times

1998 • 92 citations

p300/CREB Binding Protein-Related Protein p270 Is a Component of Mammalian SWI/SNF Complexes

1998 • 90 citations

A role for histones H2A/H2B in chromatin folding and transcriptional repression.

1994 • 84 citations

p300 stimulates transcription instigated by ligand-bound thyroid hormone receptor at a step subsequent to chromatin disruption

1999 • 78 citations

Assembly of regularly spaced nucleosome arrays by Drosophila chromatin assembly factor 1 and a 56-kDa histone-binding protein.

1995 • 74 citations

Suppression of the p300-dependent mdm2negative-feedback loop induces the p53 apoptotic function

1998 • 74 citations

Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.

1992 • 73 citations

Histone Deacetylase Directs the Dominant Silencing of Transcription in Chromatin: Association with MeCP2 and the Mi-2 Chromodomain SWI/SNF ATPase

1998 • 66 citations

E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity

1995 • 64 citations

Function for p300 and not CBP in the apoptotic response to DNA damage

1999 • 58 citations

Specificity of Cyclin E-Cdk2, TFIIB, and E1A Interactions with a Common Domain of the p300 Coactivator

1999 • 56 citations

CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment

1999 • 55 citations

Interaction of RNA polymerase II with structurally altered nucleosomal particles

1989 • 50 citations

Life with nucleosomes: chromatin remodelling in gene regulation

1998 • 43 citations

The adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300.

1994 • 40 citations

Signaling to Chromatin through Histone Modifications: How Clear Is the Signal?

1998 • 36 citations

In Vivo Functions of Histone Acetylation/Deacetylation in Tup1p Repression and Gcn5p Activation

1998 • 34 citations

Protein acetylation: more than chromatin modification to regulate transcription

1997 • 34 citations

Enhanced transcription factor access to arrays of histone H3/H4 tetramer⋅DNA complexes in vitro : Implications for replication and transcription

1998 • 31 citations

Localization of human CREBBP (CREB Binding Protein) to 16p13.3 by fluorescence in situ hybridization

1995 • 10 citations

Localization of human CREB-binding protein gene (CREBBP) to 16p13.2-p13.3 by fluorescence in situ hybridization.

1995 • 7 citations