Chromosome territories, nuclear architecture and gene regulation in mammalian cells

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Handbook Of Biological Confocal Microscopy

2006 • 3,531 citations

Handbook of Biological Confocal Microscopy

1995 • 1,850 citations

Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission

2000 • 1,736 citations

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

Histone–GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells

1998 • 957 citations

Structure and Function in the Nucleus

1998 • 925 citations

Differences in the Localization and Morphology of Chromosomes in the Human Nucleus

1999 • 902 citations

Replicon Clusters Are Stable Units of Chromosome Structure: Evidence That Nuclear Organization Contributes to the Efficient Activation and Propagation of S Phase in Human Cells

1998 • 815 citations

Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

1997 • 792 citations

The Organization of Replication and Transcription

1999 • 750 citations

Size-dependent DNA Mobility in Cytoplasm and Nucleus

2000 • 740 citations

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition.

1996 • 709 citations

Molecular biology of the cell

1993 • 679 citations

The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells

2001 • 673 citations

Protein Dynamics: Implications for Nuclear Architecture and Gene Expression

2001 • 664 citations

Interphase chromosomes undergo constrained diffusional motion in living cells

1997 • 656 citations

Fine structural organization of the interphase nucleus in some mammalian cells

1969 • 632 citations

The dynamics of a pre-mRNA splicing factor in living cells

1997 • 604 citations

Gene gating: a hypothesis.

1985 • 599 citations

Dynamics of DNA Replication Factories in Living Cells

2000 • 572 citations

Role of Chromosome Territories in the Functional Compartmentalization of the Cell Nucleus

1993 • 504 citations

Three-dimensional architecture of a polytene nucleus

1983 • 453 citations

Anomalous diffusion of fluorescent probes inside living cell nuclei investigated by spatially-resolved fluorescence correlation spectroscopy

2000 • 449 citations

Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus

1986 • 436 citations

Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei

2000 • 433 citations

Perturbation of Nuclear Architecture by Long-Distance Chromosome Interactions

1996 • 425 citations

Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division

1999 • 393 citations

The Promise of Comparative Genomics in Mammals

2001 • 387 citations

To be or not to be in the nucleolus

2000 • 381 citations

The nuclear pore complex: from molecular architecture to functional dynamics

1999 • 343 citations

A view of Interphase Chromosomes

1990 • 341 citations

Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: Coral red (dsRed) and yellow (Citrine)

2000 • 340 citations

A Chromatin Insulator Determines the Nuclear Localization of DNA

2000 • 337 citations

Structure and dynamics of human interphase chromosome territories in vivo

1998 • 333 citations

Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure.

1994 • 331 citations

Nuclear bodies: multifaceted subdomains of the interchromatin space

1999 • 330 citations

Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus

2000 • 312 citations

Experimental observations of a nuclear matrix

2001 • 311 citations

A random-walk/giant-loop model for interphase chromosomes.

1995 • 306 citations

Visualization of gene activity in living cells

2000 • 305 citations

Nuclear Organization of Mammalian Genomes

1999 • 299 citations

Nuclear organization of DNA replication in primary mammalian cells

2000 • 298 citations

Half a Century of “The Nuclear Matrix”

2000 • 295 citations

Chromosome Territories, Interchromatin Domain Compartment, and Nuclear Matrix: An Integrated View of the Functional Nuclear Architecture

2000 • 294 citations

Spatial and Temporal Dynamics of DNA Replication Sites in Mammalian Cells

1998 • 294 citations

Perichromatin fibrils are in situ forms of nascent transcripts

1994 • 290 citations

Arrangement of chromatin in the nucleus

1980 • 283 citations

Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells

1998 • 276 citations

Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments

1982 • 271 citations

Active and inactive genes localize preferentially in the periphery of chromosome territories.

1996 • 265 citations

Ultrastructural Analysis of Transcription and Splicing in the Cell Nucleus after Bromo-UTP Microinjection

1999 • 256 citations

The distribution of CpG islands in mammalian chromosomes

1994 • 254 citations

Spatial Relationship between Transcription Sites and Chromosome Territories

1999 • 250 citations

Spatial Organization of Large-Scale Chromatin Domains in the Nucleus: A Magnified View of Single Chromosome Territories

1997 • 246 citations

A Functional Enhancer Suppresses Silencing of a Transgene and Prevents Its Localization Close to Centromeric Heterochromatin

1999 • 244 citations

Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries

1993 • 241 citations

Homologous Association of Oppositely Imprinted Chromosomal Domains

1996 • 238 citations

Size-Dependent Positioning of Human Chromosomes in Interphase Nuclei

2000 • 226 citations

Stopped at the border: boundaries and insulators

1999 • 222 citations

Cell biology of transcription and pre-mRNA splicing: nuclear architecture meets nuclear function

2000 • 218 citations

Compartmentalization of Interphase Chromosomes Observed in Simulation and Experiment

1999 • 207 citations

Quantitative Motion Analysis of Subchromosomal Foci in Living Cells Using Four-Dimensional Microscopy

1999 • 199 citations

Direct Imaging of DNA in Living Cells Reveals the Dynamics of Chromosome Formation

1999 • 198 citations

Processing of Endogenous Pre-mRNAs in Association with SC-35 Domains Is Gene Specific

1999 • 194 citations

Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells

1999 • 190 citations

Interphase movements of a DNA chromosome region modulated by VP16 transcriptional activator

2001 • 182 citations

Nuclear bodies (NBs): A newly “rediscovered” organelle

1992 • 178 citations

Reduced Mobility of the Alternate Splicing Factor (Asf) through the Nucleoplasm and Steady State Speckle Compartments

2000 • 175 citations

Movement of the X Chromosome in Epilepsy

1988 • 169 citations

Precise Spatial Positioning of Chromosomes During Prometaphase: Evidence for Chromosomal Order

1995 • 165 citations

Association of Chromosome Territories with the Nuclear Matrix

1999 • 160 citations

DNA Methylation and Histone Deacetylation in the Control of Gene Expression: Basic Biochemistry to Human Development and Disease

2001 • 150 citations

Transcription Sites Are Not Correlated with Chromosome Territories in Wheat Nuclei

1998 • 148 citations

Large-scale Chromosomal Movements During Interphase Progression in Drosophila

1998 • 142 citations

Mapping Interactions between Nuclear Transport Factors in Living Cells Reveals Pathways through the Nuclear Pore Complex

2000 • 141 citations

Organization of Early and Late Replicating DNA in Human Chromosome Territories

1999 • 141 citations

Nuclear Organization and Gene Expression

1996 • 136 citations

High resolution analysis of interphase chromosome domains

2000 • 129 citations

Ultrastructure of the Nucleus in Relation to Transcription and Splicing: Roles of Perichromatin Fibrils and Interchromatin Granules

1996 • 129 citations

Compartmentalization of Eukaryotic Gene Expression: Causes and Effects

1997 • 127 citations

Transcription Factor Dosage Affects Changes in Higher Order Chromatin Structure Associated with Activation of a Heterochromatic Gene

2000 • 124 citations

Two-photon excitation 4Pi confocal microscope: Enhanced axial resolution microscope for biological research

1995 • 124 citations

The 3D Positioning of ANT2 and ANT3 Genes within Female X Chromosome Territories Correlates with Gene Activity

1999 • 117 citations

Two-color fluorescence labeling of early and mid-to-late replicating chromatin in living cells.

2001 • 106 citations

Unscheduled DNA synthesis after partial UV irradiation of the cell nucleus

1979 • 105 citations

Chromatin organization re-viewed

1995 • 103 citations

Laser Microbeam as a Tool in Cell Biology

1991 • 102 citations

Separate and variably shaped chromosome arm domains are disclosed by chromosome arm painting in human cell nuclei.

1998 • 95 citations

Nuclear organization and gene expression: homologous pairing and long-range interactions

1997 • 86 citations

Higher Levels of Organization in the Interphase Nucleus of Cycling and Differentiated Cells

2000 • 85 citations

The new paradigm: Integrating genomic function and nuclear architecture

1998 • 81 citations

Ultrastructural aspects of the ribonucleo-protein network in nuclei of walker tumor and rat liver

1967 • 81 citations

Replicon clusters may form structurally stable complexes of chromatin and chromosomes

1994 • 78 citations

Visualization of interphase chromosomes

1977 • 77 citations

Chromosome Structure and Function

1972 • 73 citations

A Polymer Model for the Structural Organization of Chromatin Loops and Minibands in Interphase Chromosomes

1998 • 60 citations

The Interphase Nucleus as a Dynamic Structure

1994 • 60 citations

Evidence for a Relatively Random Array of Human Chromosomes on the Mitotic Ring

1999 • 55 citations

Radiation-produced chromosome aberrations: colourful clues

2000 • 55 citations

Four-dimensional multiphoton microscopy with time-correlated single-photon counting

2000 • 52 citations

Mini review: Form and function in the human interphase chromosome

2000 • 48 citations

Cytochemical nucleic acid research during the twentieth century.

2000 • 47 citations

Different distributions of homologous chromosomes in adult human Sertoli cells and in lymphocytes signify nuclear differentiation

1996 • 40 citations

Evidence against a Looped Structure of the Inactive Human X-Chromosome Territory

1998 • 39 citations

A specific conformation of the territory of chromosome 17 locates ERBB - 2 sequences to a DNase-hypersensitive domain at the nuclear periphery

1998 • 38 citations

Chromatin structure and chromosome aberrations: modeling of damage induced by isotropic and localized irradiation

1998 • 36 citations

Topology of double minutes (dmins) and homogeneously staining regions (HSRs) in nuclei of human neuroblastoma cell lines

2000 • 36 citations

Synthesis, Processing, and Transport of RNA within the Three-Dimensional Context of the Cell Nucleus

1999 • 29 citations

Higher-order structure of interphase chromosomes and radiation-induced chromosomal exchange aberrations

2000 • 28 citations

The nucleus: a highly organized but dynamic structure

2000 • 24 citations

Dynamics of structure-function relationships in interphase nuclei

1999 • 23 citations

Chapter 20 Application and Detection of IdUrd and CldUrd as Two Independent Cell–Cycle Markers

1994 • 20 citations

Nuclear Architecture

1999 • 18 citations

Association of DNAse sensitive chromatin domains with the nuclear periphery in 3T3 cells in vitro

2000 • 16 citations

Association of DNAse sensitive chromatin domains with the nuclear periphery in 3T3 cells in vitro

2000 • 9 citations