The Ubiquitin Ligase SCF ^Fbw7 Antagonizes Apoptotic JNK Signaling

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

1999 • 1,756 citations

SCF and Cullin/RING H2-Based Ubiquitin Ligases

1999 • 1,249 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast

2000 • 799 citations

Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF ^Fbw7 Ubiquitin Ligase

2001 • 733 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

2001 • 575 citations

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

1997 • 462 citations

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

2001 • 420 citations

The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog

2001 • 401 citations

Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

2001 • 374 citations

Identification of a family of human F-box proteins

1999 • 369 citations

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

2003 • 368 citations

hCDC4 gene mutations in endometrial cancer.

2002 • 267 citations

Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver

2002 • 266 citations

The Ras recruitment system, a novel approach to the study of protein–protein interactions

1998 • 210 citations

The SCF Ubiquitin Ligase

2002 • 153 citations

The JNKK2-JNK1 Fusion Protein Acts As a Constitutively Active c-Jun Kinase That Stimulates c-Jun Transcription Activity

1999 • 110 citations

Characterization of a Mouse Gene (Fbxw6) That Encodes a Homologue of Caenorhabditis elegans SEL-10

2001 • 24 citations