Techniques and concepts in exocytosis: focus on mast cells

Methods of Enzymatic Analysis

1975 • 20,446 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Methods of enzymatic analysis

1964 • 5,230 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Muscarinic activation of ionic currents measured by a new whole-cell recording method.

1988 • 1,777 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Nerve, Muscle and Synapse

1966 • 1,431 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Ciba Foundation Symposium

1957 • 1,100 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

Single channel recording

1984 • 981 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart

1883 • 941 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW

1971 • 870 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

INTRACELLULAR TRANSPORT OF SECRETORY PROTEINS IN THE PANCREATIC EXOCRINE CELL

1967 • 746 citations

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1981 • 742 citations

Rates of diffusional exchange between small cells and a measuring patch pipette

1988 • 712 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers

1991 • 690 citations

Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

1988 • 674 citations

Calcium Ionophores and Movement of Calcium Ions following the Physiological Stimulus to a Secretory Process

1973 • 631 citations

Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity.

1990 • 600 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Measurement of forces between lecithin bilayers

1976 • 562 citations

The Receptor with High Affinity for Immunoglobulin E

1986 • 540 citations

Do GTPases direct membrane traffic in secretion?

1988 • 540 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

Capacitance measurements reveal stepwise fusion events in degranulating mast cells

1984 • 506 citations

Calcium-dependence of catecholamine release from bovine adrenal medullary cells after exposure to intense electric fields

1982 • 500 citations

Involvement of GTP-binding “G” proteins in transport through the Golgi stack

1987 • 495 citations

Formation and resealing of pores of controlled sizes in human erythrocyte membrane

1977 • 493 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

1991 • 441 citations

Currents through the fusion pore that forms during exocytosis of a secretory vesicle

1987 • 432 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

ATP4- permeabilizes the plasma membrane of mouse macrophages to fluorescent dyes.

1987 • 407 citations

Mechanism of membrane damage by streptolysin-O

1985 • 398 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

The Ca signal from fura‐2 loaded mast cells depends strongly on the method of dye‐loading

1985 • 356 citations

Calcium and GTP: essential components in vesicular trafficking between the endoplasmic reticulum and Golgi apparatus.

1989 • 351 citations

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

1984 • 351 citations

Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima.

1982 • 351 citations

Ionic channels formed byStaphylococcus aureus alpha-toxin: Voltage-dependent inhibition by divalent and trivalent cations

1986 • 349 citations

The effects of substance P on histamine and 5‐hydroxytryptamine release in the rat

1982 • 347 citations

Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.

1974 • 340 citations

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

1986 • 339 citations

Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels

1984 • 334 citations

A role for calpactin in calcium-dependent exocytosis in adrenal chromaffin cells

1989 • 321 citations

ELECTRON MICROSCOPE OBSERVATIONS ON COMPOUND 48/80-INDUCED DEGRANULATION IN RAT MAST CELLS

1971 • 319 citations

Calcium-dependent exocytosis in bovine adrenal medullary cells with leaky plasma membranes

1978 • 315 citations

Direct activation of GTP‐binding regulatory proteins (G‐proteins) by substance P and compound 48/80

1990 • 301 citations

Molecular events during membrane fusion. A study of exocytosis in rat peritoneal mast cells.

1977 • 289 citations

Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin

1987 • 280 citations

A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii.

1979 • 278 citations

Gaining access to the cytosol: the technique and some applications of electropermeabilization

1986 • 275 citations

Calpactins: two distinct Ca++-regulated phospholipid- and actin-binding proteins isolated from lung and placenta.

1987 • 275 citations

The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cells

1983 • 269 citations

Properties of the fusion pore that forms during exocytosis of a mast cell secretory vesicle

1990 • 262 citations

Exocytosis

1990 • 260 citations

Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin.

1987 • 256 citations

GE: A GTP-Binding Protein Mediating Exocytosis

1990 • 256 citations

Identification of Cellular Activation Mechanisms Associated with Salivary Secretion

1986 • 253 citations

ATP induces nucleotide permeability in rat mast cells

1979 • 252 citations

Calcium control of exocytosis and endocytosis in bovine adrenal medullary cells

1981 • 250 citations

Evaluation by Radioimmunoassay of Factors Controlling the Secretion of Parathyroid Hormone: Intravenous Infusions of Calcium and Ethylenediamine Tetraacetic Acid in the Cow and Goat

1966 • 249 citations

The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum.

1988 • 245 citations

Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

1987 • 244 citations

Histamine release by compounds of simple chemical structure.

1957 • 241 citations

Arrest of membrane fusion events in mast cells by quick-freezing.

1980 • 241 citations

Guanine nucleotides decrease the free [Ca²⁺] required for secretion of serotonin from permeabilized blood platelets

1984 • 236 citations

The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants.

1989 • 234 citations

Gelsolin: Calcium‐ and polyphosphoinositide‐regulated actin‐ modulating protein

1987 • 228 citations

Evidence that the inositol phospholipids are necessary for exocytosis. Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP

1990 • 227 citations

The ATP4- receptor of rat mast cells

1980 • 227 citations

Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.

1986 • 225 citations

Mycotoxins and phycotoxins

1988 • 221 citations

Beginning of exocytosis captured by rapid-freezing of Limulus amebocytes.

1981 • 212 citations

Cytosolic Ca2+, exocytosis, and endocytosis in single melanotrophs of the rat pituitary

1990 • 208 citations

New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin

1987 • 205 citations

Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis.

1987 • 197 citations

Membrane fusion during secretion: cortical granule exocytosis in sex urchin eggs as studied by quick-freezing and freeze-fracture.

1979 • 196 citations

Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages

1991 • 195 citations

Calcium and synaptic transmission in a sympathetic ganglion

1940 • 194 citations

Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms.

1988 • 189 citations

Essential synergy between Ca2+ and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells.

1987 • 188 citations

Quantal Mechanism of Neural Transmitter Release

1971 • 188 citations

Transmitter release from synapses: Does a preassembled fusion pore initiate exocytosis?

1990 • 186 citations

Anti-α-fodrin inhibits secretion from permeabilized chromaffin cells

1987 • 184 citations

INHIBITION BY NEOMYCIN OF POLYPHOSPHOINOSITIDE TURNOVER IN SUBCELLULAR FRACTIONS OF GUINEA‐PIG CEREBRAL CORTEX IN VITRO

1976 • 182 citations

Formation of Prostaglandins during the Aggregation of Human Blood Platelets

1973 • 180 citations

IgE-mediated degranulation of mast cells does not require opening of ion channels

1986 • 179 citations

A permeable animal cell preparation for studying macromolecular synthesis. DNA synthesis and the role of deoxyribonucleotides in S phase initiation

1978 • 178 citations

Voltage-dependent ion channels in T-lymphocytes

1985 • 170 citations

Exocytosis in mast cells by basic secretagogues: evidence for direct activation of GTP-binding proteins.

1990 • 169 citations

The Role of Calcium in Stimulus-Secretion Coupling in Excitable and Non-Excitable Cells

1988 • 168 citations

Localization and subcellular distribution of smg p25A, a ras p21-like GTP-binding protein, in rat brain.

1990 • 163 citations

Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells.

1990 • 162 citations

Direct measurement of exocytosis and calcium currents in single vertebrate nerve terminals

1990 • 158 citations

Cytosolic Ca²⁺ and the regulation of secretion in parathyroid cells

1986 • 154 citations

Minimal requirements for exocytosis. A study using PC 12 cells permeabilized with staphylococcal alpha-toxin.

1985 • 154 citations

A generalized theory of the transition time for sequential enzyme reactions

1981 • 153 citations

Acetylcholine metabolism in the central nervous system

1939 • 152 citations

ATP‐sensitive K+ channels in rat pancreatic beta‐cells: modulation by ATP and Mg2+ ions.

1989 • 152 citations

SOME STUDIES ON THE RELEASE OF HISTAMINE FROM MAST CELLS STIMULATED WITH POLYLYSINE

1980 • 151 citations

High extracellular Ca²⁺ and Mg²⁺ stimulate accumulation of inositol phosphates in bovine parathyroid cells

1987 • 149 citations

The ultrastructure of the cortical granules and their products in the sea urchin egg as studied with the electron microscope

1956 • 149 citations

Patch clamp studies of single cell-fusion events mediated by a viral fusion protein

1989 • 148 citations

Characterization of hormone and protein release from alpha-toxin-permeabilized chromaffin cells in primary culture.

1986 • 147 citations

A patch-clamp study of histamine-secreting cells.

1986 • 147 citations

Preferential generation of leukotriene C4 by human eosinophils.

1984 • 141 citations

A Family of Long-Acting Depressors

1949 • 140 citations

EFFECTS OF EXTRACELLULAR CA⁺⁺AND MG⁺⁺ON CYTOSOLIC CA⁺⁺AND PTH RELEASE IN DISPERSED BOVINE PARATHYROID PETI

1983 • 139 citations

Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride.

1987 • 139 citations

Freeze-fracture of membrane fusions during exocytosis in pancreatic B-cells.

1977 • 139 citations

Presence of three pertussis toxin substrates and G_oα immunoreactivity in both plasma and granule membranes of chromaffin cells

1987 • 138 citations

Mastoparan interacts with the carboxyl terminus of the alpha subunit of Gi.

1990 • 138 citations

An osmotic mechanism for exocytosis from dissociated chromaffin cells.

1984 • 137 citations

Peripheral actin filaments control calcium-mediated catecholamine release from streptolysin-O-permeabilized chromaffin cells.

1988 • 137 citations

Okadaic acid as the causative toxin of diarrhetic shellfish poisoning in Europe.

1986 • 136 citations

Compound versus multigranular exocytosis in peritoneal mast cells.

1990 • 135 citations

GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels.

1988 • 134 citations

Guanine nucleotide effects on catecholamine secretion from digitonin-permeabilized adrenal chromaffin cells.

1986 • 131 citations

Metabolism and biochemistry of mycophenolic acid.

1972 • 131 citations

The tetanus toxin light chain inhibits exocytosis

1989 • 129 citations

Exocytosis (Secretory Granule Extrusion) Induced by Injection of Calcium into Mast Cells

1973 • 128 citations

Simultaneous measurements of cytosolic calcium and secretion in single bovine adrenal chromaffin cells by fluorescent imaging of fura-2 in cocultured cells.

1989 • 127 citations

Chapter 4 Poration by α-Toxin and Streptolysin O: An Approach to Analyze Intracellular Processes

1989 • 126 citations

Rat mast cells permeabilised with streptolysin O secrete histamine in response to Ca2+ at concentrations buffered in the micromolar range

1987 • 126 citations

Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole.

1977 • 125 citations

Changes in the state of actin during the exocytotic reaction of permeabilized rat mast cells.

1990 • 124 citations

Loss of proteins from digitonin-permeabilized adrenal chromaffin cells essential for exocytosis.

1987 • 124 citations

Guanine nucleotides stimulate polyphosphoinositide phosphodiesterase and exocytotic secretion from HL60 cells permeabilized with streptolysin O

1988 • 121 citations

Nature of virally mediated changes in membrane permeability to small molecules

1980 • 120 citations

ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells.

1990 • 120 citations

Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range.

1981 • 119 citations

The Effects of Nucleotides on the Expression of β-Adrenergic Adenylate Cyclase Activity in Membranes from Turkey Erythrocytes

1974 • 118 citations

The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process.

1987 • 117 citations

Stimulus-secretion coupling in bovine parathyroid cells. Dissociation between secretion and net changes in cytosolic Ca2+.

1986 • 114 citations

Introduction of Macromolecules into Bovine Adrenal Medullary Chromaffin Cells and Rat Pheochromocytoma Cells (PC12) by Permeabilization with Streptolysin O: Inhibitory Effect of Tetanus Toxin on Catecholamine Secretion

1989 • 112 citations

The role of calcium in fly salivary gland secretion analyzed with the ionophore A-23187

1973 • 112 citations

Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation

1984 • 110 citations

Purification and immunochemical characterization of the major pertussis‐toxin‐sensitive guanine‐nucleotide‐binding protein of bovine‐neutrophil membranes

1987 • 110 citations

Studies on the mechanism of polyethylene glycol-mediated cell fusion using fluorescent membrane and cytoplasmic probes.

1983 • 110 citations

The dynamics of exocytosis in human neutrophils.

1988 • 109 citations

The Role of Osmotic Forces in Exocytosis from Adrenal Chromaffin Cells

1986 • 106 citations

Approximate dimensions of membrane lesions produced by streptolysin S and streptolysin O

1983 • 105 citations

Fast calcium transients in rat peritoneal mast cells are not sufficient to trigger exocytosis.

1986 • 104 citations

Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and basophils.

1987 • 104 citations

Guanine nucleotides and Ca‐dependent exocytosis

1985 • 102 citations

Characterisation of the ATP4− receptor that mediates permeabilisation or rat mast cells

1988 • 101 citations

Direct evidence for a role for Ca2+ in amine storage granule secretion by human platelets

1980 • 99 citations

Exocytosis induction in Paramecium tetraurelia cells by exogenous phosphoprotein phosphatase in vivo and in vitro: possible involvement of calcineurin in exocytotic membrane fusion.

1987 • 96 citations

Thrombin and activators of protein kinase C modulate secretory responses of permeabilised human platelets induced by Ca²⁺

1984 • 94 citations

Subcellular localization and quantitation of the major neutrophil pertussis toxin substrate, Gn.

1988 • 94 citations

A new GTP-binding protein in differentiated human leukemic (HL-60) cells serving as the specific substrate of islet-activating protein, pertussis toxin.

1987 • 93 citations

Mechanism of arachidonic acid release in human polymorphonuclear leukocytes

1983 • 93 citations

Calculation of time constants for intracellular diffusion in whole cell patch clamp configuration

1988 • 92 citations

The internal pH of mast cell granules

1980 • 92 citations

Permeabilization of transformed cells in culture by external ATP

1985 • 92 citations

The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells

1989 • 91 citations

Calcium and the Control of Renin Secretion*

1987 • 90 citations

Glucose-induced phospholipid hydrolysis in isolated pancreatic islets: quantitative effects on the phospholipid content of arachidonate and other fatty acids

1986 • 90 citations

Is swelling of the secretory granule matrix the force that dilates the exocytotic fusion pore?

1991 • 89 citations

1-O-Hexadecyl-2-O-methylglycerol, a Novel Inhibitor of Protein Kinase C, Inhibits the Respiratory Burst in Human Neutrophils

1989 • 89 citations

Water near intracellular surfaces.

1984 • 89 citations

Synchronous exocytosis in Paramecium cells involves very rapid (less than or equal to 1 s), reversible dephosphorylation of a 65-kD phosphoprotein in exocytosis-competent strains.

1985 • 88 citations

The effect of ATP and Ca2+ on the cell volume in isolated kidney tubules

1972 • 87 citations

Requirements for hormone release from permeabilized nerve endings isolated from the rat neurohypophysis.

1987 • 87 citations

Regulation of insulin secretion from islets of Langerhans rendered permeable by electric discharge

1982 • 86 citations

Mast cell activation — a receptor‐independent mode of substance P action?

1987 • 85 citations

Ionomycin stimulates mast cell histamine secretion by forming a lipid-soluble calcium complex

1979 • 84 citations

Action of the active metabolites of tiazofurin and ribavirin on purified IMP dehydrogenase

1988 • 83 citations

Pore formation kinetics in membranes, determined from the release of marker molecules out of liposomes or cells

1990 • 82 citations

The Relationship Between Arachidonic Acid Release and Catecholamine Secretion from Cultured Bovine Adrenal Chromaffin Cells

1984 • 81 citations

Mechanism of pertussis toxin action on the adenylate cyclase system

1984 • 80 citations

The components contained in polyethylene glycol of commercial grade (PEG-6,000) as cell fusogen

1981 • 71 citations

Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.

1989 • 71 citations

Quantitative analysis of mast cell structure

1974 • 70 citations

Regarding the Action of Hydrate of Soda, Hydrate of Ammonia, and Hydrate of Potash on the Ventricle of the Frog's Heart

1882 • 70 citations

Dual Mg²⁺ control of formyl‐peptide‐receptor–G‐protein interaction in HL 60 cells

1989 • 69 citations

Gradual and stepwise changes in the membrane capacitance of rat peritoneal mast cells.

1987 • 69 citations

Evidence That Receptor‐Linked G Protein Inhibits Exocytosis by a Post‐Second‐Messenger Mechanism in AtT‐20 Cells

1990 • 68 citations

Rat mast cells permeabilized with Sendai virus secrete histamine in response to Ca2+ buffered in the micromolar range

1983 • 68 citations

Ca2+ and cyclic nucleotide dependence of amylase release from isolated rat pancreatic acinar cells rendered permeable by intense electric fields

1984 • 67 citations

Measurement of the internal pH of mast cell granules using microvolumetric fluorescence and isotopic techniques

1987 • 67 citations

GTP gamma S stimulation of endosome fusion suggests a role for a GTP-binding protein in the priming of vesicles before fusion.

1989 • 66 citations

Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils.

1990 • 66 citations

Secretory Control in Normal and Abnormal Parathyroid Tissue

1987 • 66 citations

The use of the patch clamp technique to study second messenger-mediated cellular events

1988 • 63 citations

Specific binding ofadaic acid, a new tumor promoter in mouse skin

1989 • 63 citations

Evidence in intact cells for an involvement of GTP in the activation of adenylate cyclase.

1979 • 62 citations

A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes

1989 • 62 citations

Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins

1990 • 62 citations

Histamine release induced from mast cells by active components of compound

1985 • 61 citations

A metabolite of an antineoplastic ether phospholipid may inhibit transmembrane signalling via protein kinase C

1987 • 61 citations

Secretory responses of rat peritoneal mast cells to high intracellular calcium

1988 • 61 citations

Regulation of exocytosis in electrically permeabilized insulin-secreting cells. Evidence for Ca2+ dependent and independent secretion

1987 • 60 citations

Somatostatin inhibition of Ca2+-induced insulin secretion in permeabilized HIT-T15 cells

1990 • 60 citations

Identification of novel GTP-binding proteins in the human neutrophil

1988 • 59 citations

Protien phosphorylation and the dependence on Ca2+ and GTP-γ-S for exocytosis from permeabilised mast cells

1989 • 59 citations

A specific interaction in vitro between pancreatic zymogen granules and plasma membranes: stimulation by G-protein activators but not by Ca2+.

1989 • 59 citations

Purification of alpha-toxin from Staphylococcus aureus and application to cell permeabilization

1987 • 58 citations

A pertussis-toxin-sensitive protein controls exocytosis in chromaffin cells at a step distal to the generation of second messengers

1991 • 58 citations

Washout phenomena in dialyzed mast cells allow discrimination of different steps in stimulus-secretion coupling

1987 • 58 citations

Differential control of azurophilic and specific granule exocytosis in Sendai‐virus‐permeabilized rabbit neutrophils.

1987 • 58 citations

Reductive chain separation of botulinum A toxin — a prerequisite to its inhibitory action on exocytosis in chromaffin cells

1989 • 58 citations

Patch-clamp measurements reveal multimodal distribution of granule sizes in rat mast cells.

1990 • 57 citations

Liver membrane adenylate cyclase. Synergistic effects of anions on fluoride, glucagon, and guanyl nucleotide stimulation

1975 • 56 citations

Digitonin‐Permeabilized Cells Are Exocytosis Competent

1987 • 55 citations

A Mathematical Model for the Influence of Fructose 6‐Phosphate, ATP, Potassium, Ammonium and Magnesium on the Phosphofructokinase from Rat Erythrocytes

1974 • 54 citations

Guanine nucleotides are potent secretagogues in permeabilized parathyroid cells

1986 • 53 citations

Protein tyrosine phosphatase stimulates Ca(2+)-dependent amylase secretion from pancreatic acini.

1991 • 52 citations

Effects of prostaglandin I2 and forskolin on the secretion from platelets evoked at basal concentrations of cytoplasmic free calcium by thrombin, collagen, phorbol ester and exogenous diacylglycerol

1984 • 52 citations

Use of a High Voltage Technique to Determine the Molecular Requirements for Exocytosis in Islet Cells

1980 • 52 citations

Agonist‐induced changes in cell membrane capacitance and conductance in dialysed pancreatic acinar cells of rats.

1988 • 50 citations

Ionic Channels in Leukocytes

1986 • 50 citations

Is purified poly(ethylene glycol) able to induce cell fusion?

1982 • 50 citations

Catecholamine inhibition of Ca²⁺‐induced insulin secretion from electrically permeabilised islets of Langerhans

1987 • 49 citations

Calcium-Controlled Secretion Is Effected through a Guanine Nucleotide Regulatory Protein in Parathyroid Cells

1986 • 49 citations

Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells

1986 • 47 citations

Molecular weight studies on the active constituents of compound 48/80

1972 • 47 citations

Intracellular K+, Na+ and Cl− concentrations and membrane potential in human moncytes

1987 • 47 citations

Neomycin is a potent secretagogue of mast cells that directly activates a GTP-binding protein involved in exocytosis.

1990 • 46 citations

The dual effector system for exocytosis in mast cells: Obligatory requirement for both Ca2+ and GTP

1987 • 45 citations

Mechanisms of granule enzyme secretion from permeabilized guinea pig eosinophils. Dependence on Ca2+ and guanine nucleotides.

1991 • 44 citations

Soluble proteins as modulators of the exocytotic reaction of permeabilised rat mast cells

1989 • 44 citations

Control of Secretion in Anterior Pituitary Cells - Linking ion Channels, Messengers and Exocytosis

1988 • 43 citations

ATP and guanine nucleotide dependence of neutrophil activation. Evidence for the involvement of two distinct GTP-binding proteins.

1990 • 43 citations

Micromolar concentrations of free calcium provoke secretion of lysozyme from human neutrophils permeabilized with saponin.

1985 • 43 citations

ELECTRIC IMPEDANCE OF HIPPONOË EGGS

1935 • 43 citations

Molecular mechanisms of membrane fusion: Steps during phospholipid and exocytotic membrane fusion

1987 • 42 citations

Evidence for control of mast cell granule protease in situ by low pH*1

1983 • 42 citations

Relationship between arachidonic acid release and Ca2+-dependent exocytosis in digitonin-permeabilized bovine adrenal chromaffin cells

1990 • 42 citations

Relationship between arachidonate release and exocytosis in permeabilized human neutrophils stimulated with formylmethionyl-leucyl-phenylalanine (fMetLeuPhe), guanosine 5′-[γ-thio]triphosphate (GTP[S]) and Ca2+

1991 • 42 citations

Anaphylatoxin binding and degradation by rat peritoneal mast cells. Mechanisms of degranulation and control.

1990 • 41 citations

Dual effects of G‐protein activation on Ca‐dependent exocytosis in bovine lactotrophs

1989 • 41 citations

A role for anion transport in the regulation of release from chromaffin granules and exocytosis from cells

1977 • 40 citations

Direct activation by okadaic acid of the contractile elements in the smooth muscle of guinea-pig taenia coli

1987 • 40 citations

Factors affecting dense and alpha-granule secretion from electropermeabilized human platelets: Ca(2+)-independent actions of phorbol ester and GTP gamma S.

1990 • 40 citations

Horse eosinophil degranulation induced by the ionophore A23187. Ultrastructure and role of phospholipase A2.

1983 • 40 citations

Calcium- and guanine-nucleotide-dependent exocytosis in permeabilized rat mast cells. Modulation by protein kinase C

1990 • 39 citations

ATP-dependent and ATP-independent pathways of exocytosis revealed by interchanging glutamate and chloride as the major anion in permeabilized mast cells.

1990 • 39 citations

Stimulation of Ca2+-independent catecholamine secretion from digitonin-permeabilized bovine adrenal chromaffin cells by guanine nucleotide analogues. Relationship to arachidonate release

1990 • 39 citations

Phospholipase A2-induced rat mast cell secretion. Role of arachidonic acid metabolites.

1982 • 39 citations

Aspects of signal transduction in stimulus exocytosis‐coupling in Paramecium

1988 • 38 citations

Role of G-proteins in T cell activation: non-hydrolysable GTP analogues induce early ornithine decarboxylase activity in human T lymphocytes.

1986 • 38 citations

Evidence against direct involvement of cyclic AMP-dependent protein phosphorylation in the exocytosis of amylase

1988 • 38 citations

Phosphoprotein inhibition of calcium-stimulated exocytosis in sea urchin eggs.

1991 • 35 citations

Coordinated Action of Calcium Ion and Adenosine 3′,5′-Monophosphate upon the Release of α-Melanocyte-Stimulating Hormone from the Intermediate Lobe of the Rat Pituitary Gland

1982 • 35 citations

Effects of guanine nucleotides on the properties of 5‐hydroxytryptamine secretion from electropermeabilised human platelets

1986 • 35 citations

Ca2+-dependent amylase secretion from pancreatic acinar cells occurs without activation of phospholipase C linked G-proteins

1991 • 35 citations

Activation of cardiac G-proteins by muscarinic acetylcholine receptors: regulation by Mg2+ and Na+ ions

1989 • 34 citations

Guanine nucleotides reduce the free calcium requirement for secretion of granule constituents from permeabilized human neutrophils

1986 • 34 citations

Secretion from rat basophilic leukaemia cells induced by calcium ionophores Effect of pH and metabolic inhibition

1981 • 33 citations

ATP inhibits onset of exocytosis in permeabilised mast cells

1989 • 33 citations

Chemiosmotic hypotheses of exocytosis: A critique

1984 • 33 citations

Permeabilization Reveals Classical Stimulus-Secretion Coupling in Bovine Parathyroid Cells*

1987 • 32 citations

Calcium clamp of the intracellular environment

1985 • 32 citations

Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells.

1988 • 31 citations

Low molecular weight GTP-binding proteins associated with zymogen granule membranes from rat pancreas

1991 • 31 citations

Thiophosphorylation prevents catecholamine secretion by chemically skinned chromaffin cells

1984 • 31 citations

Biological effects of inhibition of guanine nucleotide synthesis by mycophenolic acid in cultured neuroblastoma cells.

1977 • 31 citations

Prolactin secretion in permeable GH3 pituitary cells is stimulated by Ca2+ and protein kinase C activators

1985 • 31 citations

Dual regulation of ACTH secretion by guanine nucleotides in permeabilized AtT-20 cells

1988 • 30 citations

Effect of nonhydrolyzable guanosine phosphate on IgE-mediated activation of phospholipase C and histamine release from rodent mast cells.

1989 • 29 citations

Does β-adrenoceptor activation stimulate Ca2+ mobilization and inositol trisphosphate formation in parotid acinar cells?

1989 • 29 citations

Intracellular stimulation of mast cells with guanine nucleotides mimic antigenic stimulation

1987 • 29 citations

Ribavirin inhibits mast cell mediator release.

1987 • 29 citations

Studies on the growth of mast cells in rats. Changes in granule size between 1 and 6 months.

1988 • 28 citations

A NUCLEAR MAGNETIC RESONANCE STUDY OF COMPOUND 48/80

1978 • 28 citations

Rat pancreatic acini permeabilised with streptolysin O secrete amylase at Ca2+ concentrations in the micromolar range, when provided with ATP and GTPγS

1990 • 27 citations

Relationship between arachidonate generation and exocytosis in permeabilized mast cells

1990 • 27 citations

Evidence for protein dephosphorylation as a permissive step in GTP-gamma-S-induced exocytosis from permeabilized mast cells.

1990 • 27 citations

A T cell receptor-associated GTP-binding protein triggers T cell receptor-mediated granule exocytosis in cytotoxic T lymphocytes.

1988 • 26 citations

Chapter 6 Exocytosis and Endocytosis: Membrane Fusion Events Captured in Rapidly Frozen Cells

1988 • 24 citations

Freeze-fracture studies of chemotactic peptide-induced exocytosis in neutrophils: evidence for two patterns of secretory granule fusion

1983 • 24 citations

Thiophosphorylation causes Ca2+-independent norepinephrine secretion from permeabilized PC12 cells

1989 • 24 citations

THE MEMBRANE CAPACITANCE OF THE SEA URCHIN EGG

1957 • 24 citations

Substance P and Arg-Pro-Lys-Pro-NH-C12-H25-induced mediator release from different mast cell subtypes of rat and guinea-pig

1989 • 23 citations

Pertussis toxin does not affect the time course of exocytosis in mast cells stimulated by intracellular application of GTP‐γ‐S

1987 • 23 citations

Mechanisms of luteinizing-hormone exocytosis in Staphylococcus aureus-α-toxin-permeabilized sheep gonadotropes

1989 • 23 citations

Stimulation and inhibition of human platelet membrane high‐affinity GTPase by neomycin

1988 • 22 citations

Energy metabolism in rat mast cells in relation to histamine secretion

1987 • 22 citations

ATP depletion in human platelets caused by permeabilization with saponin does not prevent serotonin secretion induced by collagen

1985 • 21 citations

Protein thiophosphorylation associated with secretory inhibition in permeabilized chromaffin cells

1985 • 21 citations

Stimulation of parathyroid hormone secretion by phorbol esters is associated with a decrease of cytosolic calcium

1986 • 20 citations

EFFECT OF IONIC ENVIRONMENT ON THE RELEASE OF HUMAN PLACENTAL LACTOGEN IN VITRO

1976 • 20 citations

Ca2+-induced lysis of platelet secretory granules.

1982 • 19 citations

GTPγS-induced calcium transients and exocytosis in human neutrophils

1990 • 17 citations

At the cutting edge mechanisms of luteinizing hormone secretion: new insights from studies with permeabilized cells

1991 • 17 citations

Rat mast cells degranulate in response to microinjection of guanine nucleotide

1991 • 17 citations

Guanine nucleotides and Ca²⁺‐dependent lysosomal secretion in electropermeabilised human platelets

1990 • 16 citations

Adenosine triphosphate can maintain multipotent haemopoietic stem cells in the absence of interleukin 3 via a membrane permeabilization mechanism

1988 • 15 citations

Histamine-Releasing Activity of Endogenous Peptides on Mast Cells Derived from Different Sites and Species

1989 • 15 citations

The monovalent anions chloride and azide as potent activators of NaF‐ and p(NH)ppG‐stimulation of pancreatic adenylate cyclase

1978 • 14 citations

Effects of pertussis toxin on the affinity of exocytosis for Ca2+ in bovine adrenal chromaffin cells

1990 • 14 citations

A Synthetic Ionophore for Ca²⁺: Studies with Model and Biological Systems

1981 • 14 citations

Mediation of norepinephrine effects on free cytosolic calcium in rat parotid acinar cells by α1 adrenergic receptors

1988 • 14 citations

Electrophysiological properties of three types of granulocytes in circulating blood of the newt.

1989 • 14 citations

Neomycin induces high‐affinity agonist binding of G‐protein‐coupled receptors

1989 • 14 citations

Influence of hypertonic solutions on catecholamine release from intact and permeabilized cultured chromaffin cells

1987 • 13 citations

Spectroscopic studies of rat mast cells, mouse mastocytoma cells, and compound 48/80—II

1981 • 13 citations

Modulation of the exocytotic reaction of permeabilised rat mast cells by ATP, other nucleotides and Mg2+

1991 • 13 citations

Phosphofructokinase from Plasmodium berghei. Influence of Mg2+, ATP and Mg2+-complexed ATP

1990 • 13 citations

Phosphofructokinase from Plasmodium berghei: a kinetic model of allosteric regulation

1990 • 12 citations

Effects of external calcium on acetylcholine-evoked increases in membrane capacitance in rat pancreatic acinar cells

1989 • 12 citations

Adenosine 3′,5′-cyclic monophosphate stimulates secretion of α-melanocyte-stimulating hormone from permeabilized cells of the intermediate lobe of the rat pituitary gland

1987 • 12 citations

Receptor-Operated, but Not Voltage-Operated, Calcium Channels Are Involved in Basophil Leucocyte Activation and Histamine Release

1989 • 11 citations

<b>Role of guanine nucleotide regulatory protein in histamine secretion from digitonin-permeabilized rat mast </b><b>cells </b>

1987 • 11 citations

Elevations of local cerebral glucose utilization by the β-carboline ZK 93 426

1990 • 10 citations

Adenosine 3′,5′‐cyclic monophosphate‐mediated enhancement of calcium‐evoked prolactin release from electrically permeabilised 7315c tumour cells

1988 • 10 citations

Inhibition of luteinizing-hormone exocytosis by guanosine 5′-[γ-thio]triphosphate reveals involvement of a GTP-binding protein distal to second-messenger generation

1991 • 10 citations

The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells

1990 • 9 citations

Role of GTP-binding protein in histamine release from mast cells

1989 • 9 citations

A new model for the mechanism of stimulus-secretion coupling.

1990 • 8 citations

Intracellular mechanisms in exocytotic secretion

1991 • 8 citations

Fluoroaluminates stimulate histamine secretion in the digitonin-permeabilized rat mast cells.

1988 • 8 citations

α‐Melanocyte‐stimulating hormone secretion from permeabilized intermediate lobe cells of rat pituitary gland The role of guanine nucleotides

1987 • 7 citations

Secretory properties of eosinophils

1991 • 7 citations

New membrane assembly in IgE receptor-mediated exocytosis

1990 • 6 citations

The influence of calcium on morphology and histamine content of isolated intact rat mast cell granules

1979 • 6 citations