Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

1979 • 782 citations

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.

1985 • 637 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

1986 • 477 citations

Cytochalasin D inhibits actin polymerization and induces depolymerization of actin filaments formed during platelet shape change

1981 • 460 citations

The kinetics of chemotactic peptide-induced change in F-actin content, F-actin distribution, and the shape of neutrophils.

1985 • 319 citations

Signal transduction and cytoskeletal activation in the neutrophil.

1987 • 282 citations

Substoichiometric concentrations of cytochalasin D inhibit actin polymerization. Additional evidence for an F-actin treadmill.

1979 • 259 citations

Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization.

1981 • 217 citations

Interactions of gelsolin and gelsolin-actin complexes with actin. Effects of calcium on actin nucleation, filament severing, and end blocking

1985 • 208 citations

Purification and structural properties of gelsolin, a Ca2+-activated regulatory protein of macrophages.

1980 • 189 citations

The actin filament-severing domain of plasma gelsolin.

1986 • 174 citations

Platelet activation.

1985 • 172 citations

Reversible binding of actin to gelsolin and profilin in human platelet extracts.

1987 • 162 citations

Actin-gelsolin interactions. Evidence for two actin-binding sites.

1984 • 156 citations

Structure and mobility of actin filaments as measured by quasielastic light scattering, viscometry, and electron microscopy.

1986 • 148 citations

Microinjection of gelsolin into living cells.

1987 • 143 citations

Common domain structure of Ca²⁺ and lipid‐binding proteins

1986 • 138 citations

Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.

1983 • 129 citations

Spreading of human neutrophils is immediately preceded by a large increase in cytoplasmic free calcium.

1986 • 121 citations

Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin?

1986 • 121 citations

Isolation and properties of two actin-binding domains in gelsolin.

1985 • 105 citations

Interaction of plasma gelsolin with G-actin and F-actin in the presence and absence of calcium ions.

1985 • 105 citations

An actin-nucleating activity in polymorphonuclear leukocytes is modulated by chemotactic peptides.

1986 • 103 citations

Kinetic analysis of F-actin depolymerization in the presence of platelet gelsolin and gelsolin-actin complexes.

1985 • 95 citations

Effect of villin on the kinetics of actin polymerization

1984 • 95 citations

Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe‐stimulated neutrophils

1985 • 88 citations

Purification and characterization of a gelsolin-actin complex from human platelets. Evidence for Ca2+-insensitive functions.

1983 • 88 citations

‘Phosphatido-peptide’-like complexes formed by the interaction of calcium triphosphoinositide with protein

1965 • 86 citations

Human platelets contain gelsolin. A regulator of actin filament length.

1982 • 83 citations

Plasma actin depolymerizing factor has both calcium-dependent and calcium-independent effects on actin

1983 • 81 citations

Definition of an N-terminal actin-binding domain and a C-terminal Ca2+ regulatory domain in human brevin.

1986 • 73 citations

Reversibility of gelsolin/actin interaction in macrophages. Evidence of Ca2+-dependent and Ca2+-independent pathways.

1987 • 71 citations

Ligand-Receptor Dynamics and Signal Amplification in the Neutrophil

1986 • 69 citations

Sequential binding of actin monomers to plasma gelsolin and its inhibition by vitamin D-binding protein

1986 • 59 citations

Phorbol ester induces rapid actin assembly in neutrophil leucocytes independently of changes in [Ca2+]i and pHi

1986 • 53 citations

Bovine serum brevin

1985 • 50 citations

Preparation and characterization of pig plasma and platelet gelsolins

1986 • 49 citations

Structure of molecular aggregates of 1-(3-sn-phosphatidyl)-l-myo-inositol 3,4-bis(phosphate) in water

1981 • 46 citations

Effects of semi-dilute actin solutions on the mobility of fibrin protofibrils during clot formation

1985 • 46 citations

A 90 000-dalton actin-binding protein from platelets comparison with villin and plasma brevin

1982 • 46 citations

Interactions of pig plasma gelsolin with G‐actin

1986 • 42 citations

Kinetics of actin monomer exchange at the slow growing ends of actin filaments and their relation to the elongation of filaments shortened by gelsolin

1986 • 39 citations

Annual review of cell biology

1986 • 38 citations

Human plasma gelsolin binds to fibronectin.

1984 • 32 citations

Interactions of plasma gelsolin with actin. Isolation and characterization of binary and ternary plasma-gelsolin-actin complexes

1986 • 29 citations

Fluorescence study of N-(3-pyrene)maleimide conjugated to rabbit skeletal F-actin and plasmodium actin polymers

1976 • 29 citations

Binding of pig plasma gelsolin to F‐actin and partial fractionation into calcium‐dependent and calcium‐independent forms

1986 • 27 citations

Fluorescence study of brevin, the Mr 92000 actin-capping and -fragmenting protein isolated from serum. Effect of calcium on protein conformation

1985 • 25 citations

Fluorescence spectroscopic studies of pyrene-actin adducts

1982 • 22 citations

The effect of plasma gelsolin on actin filaments Ca2+-dependency of the capping and severing activities

1985 • 15 citations