Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Light- and GTP-regulated interaction of GTPase and other proteins with bovine photoreceptor membranes

1980 • 561 citations

Simultaneous inhibitions of inositol phospholipid breakdown, arachidonic acid release, and histamine secretion in mast cells by islet-activating protein, pertussis toxin. A possible involvement of the toxin-specific substrate in the Ca2+-mobilizing receptor-mediated biosignaling system.

1985 • 509 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.

1987 • 359 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

1986 • 315 citations

Coupling of the guanine nucleotide regulatory protein to chemotactic peptide receptors in neutrophil membranes and its uncoupling by islet-activating protein, pertussis toxin. A possible role of the toxin substrate in Ca2+-mobilizing receptor-mediated signal transduction.

1985 • 281 citations

A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii.

1979 • 278 citations

Direct evidence for involvement of a guanine nucleotide-binding protein in chemotactic peptide-stimulated formation of inositol bisphosphate and trisphosphate in differentiated human leukemic (HL-60) cells. Reconstitution with Gi or Go of the plasma membranes ADP-ribosylated by pertussis toxin.

1986 • 276 citations

The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins.

1986 • 261 citations

The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.

1986 • 253 citations

Conformational change of mastoparan from wasp venom on binding with phospholipid membrane

1983 • 168 citations

Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles.

1984 • 158 citations

Voltage-dependent trans-bilayer orientation of melittin.

1982 • 135 citations

ADP-ribosylation of a Mr 21,000 membrane protein by type D botulinum toxin.

1987 • 104 citations

Functional reconstitution of beta-adrenergic receptors and the stimulatory GTP-binding protein of adenylate cyclase.

1982 • 100 citations

The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols.

1987 • 87 citations

A wasp venom mastoparan‐induced polyphosphoinositide breakdown in rat peritoneal mast cells

1985 • 78 citations

Transferred NOE analyses of conformations of peptides as bound to membrane bilayer of phospholipid; mastoparan‐X

1983 • 66 citations

Multigranular exocytosis induced by phospholipase A2-activators, melittin and mastoparan, in rat anterior pituitary cells

1986 • 60 citations

Catecholamine-stimulated guanosine 5'-O-(3-thiotriphosphate) binding to the stimulatory GTP-binding protein of adenylate cyclase: kinetic analysis in reconstituted phospholipid vesicles

1984 • 43 citations

Effects of Peptides on the Release of Catecholamines and Adenine Nucleotides from Cultured Adrenal Chromaffin Cells

1980 • 29 citations

Mechanisms of bacterial pathogenicity that involve production of calmodulin-sensitive adenylate cyclases

1987 • 21 citations

Synthesis of a wasp venom tetradecapeptide, mastoparan, with a new cleaving system for 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) amino-protecting group.

1984 • 11 citations