Activation of cardiac G-proteins by muscarinic acetylcholine receptors: regulation by Mg2+ and Na+ ions

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

The enzymatic preparation of [α-32P]nucleoside triphosphates, cyclic [32P]AMP, and cyclic [32P]GMP

1979 • 574 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization.

1978 • 314 citations

Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization

1985 • 284 citations

Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase.

1983 • 268 citations

Mammalian .beta.2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1984 • 249 citations

Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.

1986 • 225 citations

Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines.

1978 • 224 citations

Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism.

1984 • 219 citations

GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists

1979 • 178 citations

Preparation of metal-chelate complexes and the design of steady-state kinetic experiments involving metal nucleotide complexes.

1979 • 175 citations

Cardiac muscarinic cholinergic receptor binding is regulated by Na+ and guanyl nucleotides.

1980 • 140 citations

Regulation of hormone-sensitive GTP-dependent regulatory proteins by chloride.

1987 • 139 citations

Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase

1984 • 136 citations

Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.

1982 • 125 citations

Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange.

1987 • 97 citations

Muscarinic stimulation of phosphatidylinositol metabolism in atria.

1983 • 85 citations

Stimulation of a low Km GTPase by inhibitors of adipocyte adenylate cyclase.

1982 • 53 citations

Large Scale Preparation and Characterization of Membrane-Bound and Detergent-Solubilized Muscarinic Acetylcholine Receptor from Pig Atria

1984 • 53 citations

Sodium modulates opioid receptors through a membrane component different from G-proteins. Demonstration by target size analysis.

1988 • 31 citations

Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma.

1988 • 30 citations

Sodium Regulation of Hormone-Sensitive Adenylate Cyclase

1984 • 28 citations

Regulation of G-Protein-Mediated Signal Transfer by Ions

1988 • 19 citations

Regulation of G-Protein-Mediated Signal Transfer by Ions

1988 • 17 citations