New Classes of Tumor Promoters: Teleocidin, Aplysiatoxin, and Palytoxin

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Chemoprevention of Cancer

2008 • 1,269 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

1982 • 788 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Down-Regulation of the Antitumor Immune Response

1985 • 676 citations

Plant Flavonoids in Biology and Medicine, Biochemical, Pharmacological and Structure-Activity Relationships

1986 • 562 citations

Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas

1984 • 550 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation

1985 • 406 citations

Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.

1979 • 361 citations

Tumor-Promoting Phorbol Esters Inhibit Binding of Epidermal Growth Factor to Cellular Receptors

1978 • 355 citations

Seaweed Dermatitis: Structure of Lyngbyatoxin A

1979 • 339 citations

Tumor-promoting Agents in Two-stage Carcinogenesis1

2015 • 296 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents.

1982 • 290 citations

Tumorigenesis in Mouse Skin: Inhibition by Synthetic Inhibitors of Proteases

1970 • 263 citations

Structure of palytoxin

1981 • 263 citations

Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.

1981 • 254 citations

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

1984 • 219 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition

1983 • 217 citations

Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

1985 • 210 citations

Animal, Plant, and Microbial Toxins

1976 • 209 citations

Progress in Tryptophan and Serotonin Research

1984 • 184 citations

Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: Teleocidin and debromoaplysiatoxin

1984 • 181 citations

Further studies on palytoxin. II. structure of palytoxin

1981 • 176 citations

Aplysiatoxin and debromoaplysiatoxin, constituents of the marine mollusk Stylocheilus longicauda

1974 • 172 citations

Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

1981 • 171 citations

Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes.

1972 • 142 citations

Tumor promoters induce changes in the chick embryo fibroblast cytoskeleton

1979 • 138 citations

Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis

1986 • 136 citations

Phorbol esters from croton oil chemical nature and biological activities

1967 • 135 citations

Absolute stereochemistries of the aplysiatoxins and oscillatoxin A

1984 • 134 citations

A possible naturally occurring tumor promoter, teleocidin B from Streptomyces

1979 • 130 citations

Activation of protein kinase C by tumor promoting phorbol esters, teleocidin and aplysiatoxin in the absence of added calcium

1985 • 120 citations

Oncogene activation and tumor progression

1984 • 119 citations

Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate.

1984 • 117 citations

Similarity of teleocidin B and phorbol ester tumour promoters in effects on membrane receptors

1981 • 116 citations

On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

1981 • 104 citations

Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis

1986 • 103 citations

The tumor promoter, 12-O-tetradecanoylphorbol-13-acetate accelerates keratinocyte differentiation and stimulates growth of an unidentified cell type in cultured human epidermis

1982 • 97 citations

Polyamine biosynthesis and skin tumor promotion: Inhibition of 12-0-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase α-difluoromethylornithine

1982 • 90 citations

Oncogene-Induced Transformation of C3H 10T1/2 Cells Is Enhanced by Tumor Promoters

1984 • 89 citations

Direct measurment of specific binding of highly lipophilic phorbol diester to mouse epidermal membranes using cold acetone

1981 • 81 citations

Stimulation of prostaglandin E2 production by 12-O-tetradecanoylphorbol 13-acetate (TPA)-type and non-TPA-type tumor promoters in macrophages and its inhibition by cycloheximide

1985 • 78 citations

Absolute configuration oOf lyngbyatoxin A (teleocidin A-1) and teleocidin A-2

1986 • 77 citations

Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin

1984 • 75 citations

Toxins, anticancer agents, and tumor promoters from marine prokaryotes

1982 • 75 citations

Teleocidin from Streptomyces is a potent promoter of mouse skin carcinogenesis

1982 • 74 citations

The aplysiatoxins

1975 • 70 citations

A New Toxic Substance, Teleocidin, Produced by Streptomyces

1960 • 70 citations

Berberine Sulfate Inhibits Tumor-Promoting Activity of Teleocidin in Two-Stage Carcinogenesis on Mouse Skin

1986 • 69 citations

Toxins from blue-green algae: structures of oscillatoxin A and three related bromine-containing toxins

1978 • 69 citations

Isolation and structure elucidation of teleocidin B-1, B-2, B-3, and B-4.

1984 • 66 citations

Elucidation of the structure of olivoretin A and D (teleocidin B).

1984 • 65 citations

Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis.

1986 • 61 citations

Molecular requirements for epigenetic modulators. Synthesis of active fragments of teleocidins and lyngbyatoxin.

1982 • 59 citations

A two-stage mouse skin carcinogenesis study of lyngbyatoxin A

1984 • 57 citations

Estimation of tumor promoting activity and structure-function relationships of aplysiatoxins

1984 • 56 citations

A New Tumor-Promoting Agent, Dihydroteleocidin B, Markedly Enhances Chemically Induced Malignant Cell Transformation

1982 • 55 citations

Synthesis of optically active teleocidin derivatives. Absolute configuration of teleocidin B and olivoretin A.

1984 • 52 citations

Induction of differentiation of human promyelocytic leukemia (HL-60) cells by teleocidin and phorbol-12-myristate-13-acetate

1982 • 50 citations

Acute effects of 12-Otetradecanoylphorbol-13-acetate, teleocidin B, or 2,3,7,8-tetrachlorodibenzo-p-dioxin on cultured normal human bronchial epithelial cells

1984 • 50 citations

New classes of environmental tumor promoters: indole alkaloids and polyacetates.

1983 • 49 citations

Small circular DNA complexes in eucaryotic cells

1982 • 48 citations

Stimulation of DNA synthesis in murine fibroblasts by the tumour promoter teleocidin: Relationship to phorbol esters and vasopressin

1982 • 46 citations

Stimulation of arachidonic acid metabolism by different types of tumor promoters

1985 • 45 citations

Stimulation of growth of human melanocytes by tumor promoters

1983 • 42 citations

第3類の新規しゅよう促進剤,ポリアセタート(デブロモアプリシアトキシンおよびアプリシアトキシン)のしゅよう促進効果に関与する生物効果の分化

1982 • 41 citations

Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells.

1982 • 40 citations

Specific binding of the tumor promoter TPA in various mouse organs as measured by a 'cold acetone-filter assay'

1981 • 39 citations

Enhanced incorporation of radioactive inorganic phosphate into phospholipids of HeLa cells by tumor promoters

1983 • 39 citations

Activation of the EBV‐cycle and aggregation of human blood lymphocytes by the tumor promoters teleocidin, lyngbyatoxin a, aplysiatoxin and debromoaplysiatoxin

1983 • 39 citations

Teleocidin, lyngbyatoxin A and their hydrogenated derivatives, possible tumor promoters, induce terminal differentiation in HL-60 cells

1981 • 39 citations

Aggregation of human lymphoblastoid cells by tumor-promoting phorbol esters and dihydroteleocidin B

1980 • 38 citations

Focus formation in rat fibroblasts exposed to a tumour promoter after transfer of polyoma plt and myc oncogenes

1985 • 37 citations

The Aplysiatoxins: Reactions with Acid and Oxidants

1976 • 37 citations

The epstein-barr virus early antigen inducing indole alkaloids. (-)-Indolactam V and its related compounds, produced by actinomycetes.

1984 • 36 citations

Proto-oncogene expression during two-stage carcinogenesis in mouse skin

1985 • 35 citations

A blue-green alga from Okinawa contains aplysiatoxins, the third class of tumor promoters.

1985 • 34 citations

Tumor promoting activities of new synthetic analogues of teleocidin.

1985 • 33 citations

Presence of specific binding sites for phorbol ester tumor promoters in human epidermal and dermal cells in culture but lack of down regulation in epidermal cells.

1983 • 32 citations

Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxin, a Tumor Promoter

1983 • 32 citations

Induction of epstein‐barr virus by a new tumor promoter, teleocidin, compared to induction by TPA

1981 • 32 citations

Stimulation of prostaglandin production and choline turnover in Hela cells by lyngbyatoxin A and dihydroteleocidin B

1981 • 32 citations

Effects of teleocidin and the phorbol ester tumor promoters on cell transformation, differentiation, and phospholipid metabolism.

1982 • 30 citations

Elucidation of the structures of olivoretin B and C.

1984 • 29 citations

Inhibition of specific binding of [³H]phorbol-12,13-dipropionate to an epidermal fraction by certain irritants and irritant promoters of mouse skin

1983 • 29 citations

Maintenance of human skin on nude mice for studies of chemical carcinogenesis

1979 • 29 citations

Requirements for protein synthesis and calcium for stimulation of prostaglandin synthesis in cultured rat liver cells by tumor promoters.

1983 • 27 citations

Thapsigargin, constitution of a sesquiterpene lactone histamine liberator from thapsia garganica

1980 • 27 citations

The X-Ray Structure Determination of Dihydroteleocidin B Monobromoacetate

1966 • 26 citations

Potent antitumor promoting activity of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin

1984 • 26 citations

Macrophage oxidative burst and related cytotoxicity. I. Differential activation by tumor‐promoting and non‐tumor‐promoting phorbol esters

1984 • 24 citations

A combination of palytoxin with 1-oleoyl-2-acetyl-glycerol (OAG) or insulin or interleukin-1 synergistically stimulates arachidonic acid metabolism, but combinations of 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-type tumor promoters with OAG do not

1986 • 23 citations

Inhibition of DNA synthesis and sugar uptake and lack of induction of ornithine decarboxylase in human epidermal cells treated with mouse skin tumor promoters.

1984 • 23 citations

Teleocidin and phorbol ester tumor promoters exert similar mitogenic effects on human lymphocytes

1985 • 22 citations

Effects of tumor promoters on the frequency of metallothionein I gene amplification in cells exposed to cadmium.

1983 • 22 citations

Distinct inhibitory effects of dihydroteleocidin B and the phorbol ester tumor promoters on the adipocyte differentiation of 3T3-L1 cells.

1983 • 21 citations

Inhibition of Teleocidin-Caused Epidermal Ornithine Decarboxylase Induction by Phospholipase A2-, Cyclooxygenase- and Lipoxygenase-lnhibitors

1985 • 21 citations

The control of phospholipid methylation by phorbol diesters in differentiating human myeloid HL-60 leukemia cells

1982 • 20 citations

Correlation of ouabain-sensitive ion movements with cell-cycle activation.

1985 • 20 citations

A New Toxic Substance, Teleocidin, Produced by Streptomyces

1962 • 19 citations

In Vitro Induction of Human Skin Ornithine Decarboxylase by the Tumor Promoter 12-<italic>O</italic>-Tetradecanoylphorbol-13-Acetate<xref ref-type="fn" rid="FN2">2</xref>

1985 • 18 citations

The structures of additional teleocidin class tumor promoters.

1986 • 18 citations

Binding studies of [H]Lyngbyatoxin A and [H]debromoaplysiatoxin to the phorbol ester receptor in a mouse epidermal particulate fraction

1986 • 17 citations

Involvement of sulfatide in activation of protein kinase C by tumor promoters

1986 • 15 citations

Enhancement of Epstein-Barr virus-induced transformation of human lymphocytes by teleocidin

1981 • 15 citations

Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues

1983 • 14 citations

Mouse 3T3-L1 cell variants unable to respond to mitogenic stimulation of dihydroteleocidin B: genetic evidence for the synergism of tumor promoters with growth factors.

1986 • 14 citations

Interferon with novel characteristics produced by human mononuclear leukocytes

1983 • 14 citations

Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium bastmyceticum.

1985 • 12 citations

Induction of histidine decarboxylase activity in mouse skin after application of indole alkaloids, a new class of tumor promoter

1982 • 11 citations

A new tumor promoter, dihydroteleocidin b, enhances cell growth and the production of murine leukemia virus by fibroblasts

1983 • 9 citations

Differential Effect of Tumor Promoters on Phorbol‐Ester‐Receptor Binding and Membrane Fluorescence Anisotropy in C3H 10 T 1/2 Cells

1983 • 9 citations

Tumor promoters stimulate hyperplasia of microtubule organizing center and inhibit DNA synthesis in cultured cells.

1984 • 9 citations

Tumor promoters enhance cap formation in mouse thymocytes

1983 • 8 citations

Des-O-methylolivoretin C is a new member of the teleocidin class of tumor promoters.

1986 • 7 citations

Teleocidin-induced modulation of growth and cell interaction in microenvironment-dependent mouse leukemias

1983 • 7 citations

Insulinotropic effect of the tumor promoter teleocidin in isolated pancreatic islets

1983 • 6 citations

Teleocidin is not mitogenic for 12-O-tetradecanoylphorbol-13-acetate non-proliferative variants of 3T3 cells

1983 • 6 citations

Effects of aplysiatoxin and debromoaplysiatoxin on growth and differentiation of normal human bronchial epithelial cells

1984 • 6 citations

Mitogenic and comitogenic properties of the indole alkaloid class of tumor promoters

1984 • 5 citations

Induction of nitroblue tetrazolium reduction in mouse peritoneal macrophages by tumor promoters and inhibition of the induced nitroblue tetrazolium reduction by some inhibitors

1985 • 5 citations

Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin

1984 • 4 citations

Teleocidin, a tumor promoter, is a potent platelet-aggregating agent

1981 • 4 citations

Effect of teleocidin on immune responses in vitro.

1985 • 3 citations

Effects of synthetic analogues of teleocidin, indolactam-V, on the differentiation of murine pre-adipose cells

1985 • 3 citations

Modulation of natural killer susceptibility by indole alkaloid tumor promoter dihydroteleocidin B

1984 • 3 citations

Induced secretion of a Mr 46,000 protein by cultured human hepatoma cells treated with tumor promoters.

1985 • 3 citations

Antagonistic action of retinoic acid against teleocidin and 12-O-tetradecanoyl-phorbol-13-acetate on activation of Epstein-Barr virus genomes

1984 • 2 citations

<b>TUMOR PROMOTERS MAY INDUCE THE APPEARANCE OF EXTRACHROMOSOMAL CIRCULAR DNAs IN RODENT CELL </b><b>LINES </b>

1984 • 1 citations