Activator protein 1 (AP-1)– and nuclear factor κB (NF-κB)–dependent transcriptional events in carcinogenesis

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN

1999 • 1,102 citations

Free radicals, antioxidant enzymes, and carcinogenesis

1990 • 1,090 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

How to Characterize a Biological Antioxidant

1990 • 943 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Oxidative Decay of DNA

1997 • 938 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62

1992 • 825 citations

Is NF-kappaB the sensor of oxidative stress?

1999 • 786 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Distinct effects of thioredoxin and antioxidants onthe activation of transcription factors NF-kappa B and AP-1.

1994 • 694 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Is NF‐κB the sensor of oxidative stress?

1999 • 669 citations

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro.

1991 • 649 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1991 • 626 citations

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1

1998 • 580 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.

1993 • 479 citations

Role of Oxidants and Antioxidants in the Induction of AP-1, NF-κB, and Glutathione S-Transferase Gene Expression

1996 • 457 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

Inflammation and Oxidative Stress in Carcinogenesis

1993 • 419 citations

Regulatory Role for a Novel Human Thioredoxin Peroxidase in NF-κB Activation

1997 • 414 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway.

1994 • 389 citations

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

1999 • 387 citations

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.

1994 • 377 citations

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation

1997 • 375 citations

c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

1994 • 350 citations

Regulation of the transcription factors NF-κB and AP-1 by redox changes

1994 • 310 citations

The balance between copper-zinc superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress

1991 • 302 citations

Study of Gene Regulation by NF-κB and AP-1 in Response to Reactive Oxygen Intermediates

1997 • 284 citations

Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression.

1996 • 283 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1

1999 • 266 citations

転写因子NF‐κBとAP‐1の活性化に及ぼすチオレドキシンと抗酸化剤の異なった効果

1994 • 259 citations

Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation

1999 • 252 citations

Oxidant stress and carcinogenesis

1991 • 246 citations

UVB Activates ERK1/2 and p38 Signaling Pathways via Reactive Oxygen Species in Cultured Keratinocytes

1999 • 239 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals

1994 • 225 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

1995 • 220 citations

Hydrogen peroxide as a potent activator of T lymphocyte functions

1995 • 217 citations

AP1/ jun Function Is Differentially Induced in Promotion-Sensitive and Resistant JB6 Cells

1989 • 210 citations

Persistent induction of c-fos and c-jun expression by asbestos.

1993 • 208 citations

Redox Signals and NF-κB Activation in T Cells

1998 • 206 citations

Effects of oxidants and antioxidants on nuclear factor ϰB activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals

1995 • 206 citations

Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B

1999 • 200 citations

Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.

1997 • 198 citations

Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells

1998 • 198 citations

Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304

1997 • 190 citations

Role of antioxidant enzymes in cell immortalization and transformation

1988 • 190 citations

The role of the cellular antioxidant defense in oxidant carcinogenesis.

1994 • 183 citations

Redox regulation of manganese superoxide dismutase

1996 • 180 citations

Dioxin Induces Expression of c-fosand c-junProto-Oncogenes and a Large Increase in Transcription Factor AP-1

1992 • 179 citations

Oxidative Stress and Tumour Cell Proliferation

1990 • 179 citations

The Genomic Response of Tumor Cells to Hypoxia and Reoxygenation

1995 • 178 citations

Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFκB p65 protein expression

1997 • 171 citations

Induction of Oxidative Stress by Okadaic Acid Is Required for Activation of Transcription Factor NF-κB

1995 • 170 citations

Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.

1994 • 158 citations

Requirement for Phosphatidylinositol 3-Kinase in Epidermal Growth Factor-Induced AP-1 Transactivation and Transformation in JB6 P⁺ Cells

1996 • 150 citations

New perspectives on the biochemistry of superoxide anion and the efficiency of superoxide dismutases

1990 • 149 citations

Cell growth stimulation by the redox protein thioredoxin occurs by a novel helper mechanism.

1995 • 147 citations

Rel/NF-κB and IκB factors in oncogenesis

1997 • 146 citations

Role of cysteine₆₂in DNA recognition by the P50 subunit of NF-_xB

1993 • 142 citations

Transfection and Expression of MnSOD cDNA Decreases Tumor Malignancy of Human Oral Squamous Carcinoma SCC-25 Cells

1997 • 140 citations

Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element.

1996 • 139 citations

Molecular cloning of a tumor promoter‐inducible mRNA found in JB6 mouse epidermal cells: Induction is stable at high, but not at low, cell densities

1987 • 132 citations

Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA

1985 • 129 citations

Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.

1997 • 129 citations

Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3.

1994 • 124 citations

HMGI(Y) and HMGI-C Dysregulation

1999 • 121 citations

Escape from redox regulation enhances the transforming activity of Fos.

1993 • 119 citations

Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation

1998 • 117 citations

Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes

1998 • 115 citations

Pleckstrin Homology Domains

1998 • 112 citations

Phosphatidylinositol-3 Kinase Is Necessary for 12-O-Tetradecanoylphorbol-13-acetate-induced Cell Transformation and Activated Protein 1 Activation

1997 • 112 citations

Oxidative Damage to Behavior During Aging

1991 • 112 citations

Antioxidant-Inducible Genes

1996 • 111 citations

Inhibition of AP‐1 and NF‐κB by manganese‐containing superoxide dismutase in human breast cancer cells

1998 • 110 citations

Effect of glutathione depletion and oral N‐acetyl‐cysteine treatment on CD4 ⁺ and CD8 ⁺ cells

1994 • 110 citations

Phorbol ester induces manganese-superoxide dismutase in tumor necrosis factor-resistant cells.

1991 • 108 citations

Gene Regulation by Reactive Oxygen Species

1997 • 105 citations

c-Jun is phosphorylated by the DNA-dependent protein kinasein vitro; definition of the minimal kinase recognition motif

1993 • 104 citations

Ultraviolet‐A induces activation of AP‐1 in cultured human keratinocytes

1996 • 100 citations

Reactive oxygen intermediates as second messengers of a general pathogen response.

1996 • 98 citations

JNK Activation Is Required for JB6 Cell Transformation Induced by Tumor Necrosis Factor-α but Not by 12-O-Tetradecanoylphorbol-13-Acetate

1999 • 94 citations

Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells

1988 • 88 citations

Reduction of a Tetrazolium Salt and Superoxide Generation in Human Tumor Cells (HeLa)

1993 • 79 citations

Identification of Hydrogen Peroxide as the Relevant Messenger in the Activation Pathway of Transcription Factor NF-κB

1996 • 75 citations

The extracellular-signal-regulated protein kinases (Erks) are required for UV-induced AP-1 activation in JB6 cells

1999 • 73 citations

A family of mitogen-activated protein kinase-related proteins interacts in vivo with activator protein-1 transcription factor

1994 • 69 citations

Oxidant Carcinogenesis and Antioxidant Defensea

1992 • 69 citations

Molecular analysis of pleckstrin: The major protein kinase c substrate of platelets

1989 • 68 citations

Nitric Oxide Inhibits Ornithine Decarboxylase by S-Nitrosylation

1999 • 67 citations

High Mobility Group-I(Y) Protein Facilitates Nuclear Factor-κB Binding and Transactivation of the Inducible Nitric-oxide Synthase Promoter/Enhancer

1999 • 66 citations

Redox Factor-1 (Ref-1) Mediates the Activation of AP-1 in HeLa and NIH 3T3 Cells in Response to Heat Shock

1999 • 64 citations

Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells

1998 • 63 citations

The N-Terminal Domain of IκBα Masks the Nuclear Localization Signal(s) of p50 and c-Rel Homodimers

1998 • 63 citations

Molecular Cloning of Mouse Tissue Inhibitor of Metalloproteinases-3 and Its Promoter

1995 • 63 citations

Depression of catalase gene expression after immortalization and transformation of mouse liver cells

1993 • 62 citations

Superoxide Dismutases: Defence Against Endogenous Superoxide Radical

2008 • 61 citations

Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation.

1994 • 60 citations

Defective gene expression of MnSOD in cancer cells

1993 • 58 citations

Differential Regulation of Extracellular Signal-Regulated Kinase and Nuclear Factor-κB Signal Transduction Pathways by Hydrogen Peroxide and Tumor Necrosis Factor

1998 • 56 citations

Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma.

1993 • 54 citations

Expression of antisense osteopontin RNA inhibits tumor promoter-induced neoplastic transformation of mouse JB6 epidermal cells.

1995 • 51 citations

Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells

1997 • 47 citations

Transient Overexpression of Catalase Does Not Inhibit TNF- or PMA-Induced NF-κB Activation

1995 • 47 citations

The Role of the Cellular Antioxidant Defense in Oxidant Carcinogenesis

1994 • 43 citations

Differential Regulation of a Multipromoter Gene.

1995 • 41 citations

Redox Regulation of Genes that Protect Against Carcinogens

1997 • 40 citations

Differential c‐jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation

1992 • 39 citations

Biological consequences of oxidative stress; implications for cardiovascular disease and carcinogenesis

1993 • 37 citations

Molecular Cloning of the Genes Suppressed in RVC Lymphoma Cells by Topoisomerase Inhibitors

1996 • 36 citations

Protein kinase C and its substrates in tumor promoter-sensitive and -resistant cells.

1988 • 35 citations

Differences in oxygen‐dependent regulation of enzymes between tumor and normal cell systems in culture

1981 • 33 citations

Calcitriol regulation of osteopontin expression in mouse epidermal cells.

1994 • 32 citations

Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells

1998 • 31 citations

c‐jun and multistage carcinogenesis: Association of overexpression of introduced c‐jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter‐induced transformation

1995 • 31 citations

Crossed signals: oncogenic transcription factors

1992 • 31 citations

Fos and Jun. Oncogenic Transcription Factors.

1992 • 29 citations

C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells.

1995 • 29 citations

Differential expression of an 80-kDa protein kinase C substrate in preneoplastic and neoplastic mouse JB6 cells.

1989 • 28 citations

Differential roles for Fos and Jun in DNA-binding: redoxdependent and independent functions

1993 • 27 citations

The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells

1995 • 26 citations

Constitutive and phorbol‐myristate‐acetate regulated antioxidant defense of mouse epidermal JB6 cells

1989 • 25 citations

12‐O‐tetradecanoylphorbol‐13‐acetate—induced levels of ap‐1 proteins: a 46‐kda protein immunoprecipitated by anti‐fra‐1 and induced in promotion‐resistant but not promotion‐sensitive JB6 cells

1992 • 22 citations

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells.

1991 • 22 citations

Decreased expression of manganese superoxide dismutase mRNA and protein after immortalization and transformation of mouse liver cells.

1993 • 21 citations

Tumor promotion resistant cells are deficient in AP-1 DNA binding, JunD DNA binding and JunD expression and form different AP-1–DNA complexes than promotion sensitive cells

1999 • 21 citations

Specific methylation events contribute to the transcriptional repression of the mouse tissue inhibitor of metalloproteinases-3 gene in neoplastic cells.

1999 • 19 citations

Preferential primary‐response gene expression in promotion‐resistant versus promotion‐sensitive JB6 cells

1994 • 18 citations

Tumor Promoter Benzoyl Peroxide Induces Sulfhydryl Oxidation in Protein Kinase C: Its Reversibility Is Related to the Cellular Resistance to Peroxide-Induced Cytotoxicity

1999 • 18 citations

International Conference on food factors: Chemistry and cancer prevention

1996 • 18 citations

Characterization of Transgenic Mice with an Increased Content of Chromosomal Protein HMG-14 in Their Chromatin

1995 • 17 citations

Reduced expression of manganese superoxide dismutase in cells resistant to cytolysis by tumor necrosis factor

1992 • 17 citations

Oxygen free radicals and tissue damage: chairman's introduction.

1978 • 17 citations

bcl-2 enhancement of malignant transformation in mouse epidermal JB6 cells

1997 • 16 citations

cDNA Cloning and Mapping of Mouse Pleckstrin (Plek), a Gene Upregulated in Transformation-Resistant Cells

2000 • 15 citations

Genes that cooperate with tumor promoters in transformation

1987 • 15 citations

Tumor promoter-induced ornithine decarboxylase gene expression occurs independently of AP-1 activation

1999 • 14 citations

Transcriptional Activation and Redox Regulation of the Tumor Necrosis Factor-α Promoter in Human T Cells: Role of the CRE/κ3 Promoter Region

1998 • 13 citations

Calcitriol enhancement of TPA-induced tumorigenic transformation is mediated through vitamin D receptor-dependent and -independent pathways.

1997 • 13 citations

Biological consequences of oxidative stress; Implications for cardiovascular disease and carcinogenesis

1993 • 11 citations

Antioxidant enzymatic system and free radicals pathway in two different human cancer cell lines.

1996 • 11 citations

Calcitriol regulation of osteopontin expression in mouse epidermal cells

1994 • 10 citations

Differential cytotoxicity in mouse epidermal JB6 cells: A potential mechanism for oxidant tumor promotion

1994 • 10 citations

Comparison of mouse pro-1 and pro-2 transfectants for responses to tumor promoters and antipromoters.

1988 • 9 citations

Use of Mouse JB6 Cells to Identify Molecular Targets and Novel Agents for Prevention of Carcinogenesis

1997 • 9 citations

Promotion‐sensitive epidermal and mammary epithelial cells maintained in suspension over agarose

1998 • 8 citations

JB6 murine epidermal cell lines sensitive and resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation exhibit differential arachidonic acid metabolism in response to TPA and the calcium ionophore A23187

1992 • 7 citations

Analysis of transcriptional activation of a cyclic AMP response element by 2,6,10,14‐tetramethylpentadecane (pristane) in JB6 mouse epidermal cells

1994 • 6 citations

Promotion-resistant JB6 mouse epidermal cells exhibit defects in phosphatidylethanolamine synthesis and phorbol ester-induced phosphatidylcholine hydrolysis

1997 • 5 citations

Effects of Okadaic Acid on Calcitriol‐and Phorbol Ester‐Induced Expression and Phosphorylation of Osteopontin in Mouse JB6 Epidermal Cells^a

1995 • 4 citations

Differential induction of 15 and 16 kDa nuclear proteins in promotion sensitive and promotion resistant mouse JB6 cells.

1992 • 3 citations

Carba-prostacydin inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation in sensitive murine epidermal JB6 cells

1992 • 3 citations

Chairman's Introduction

2008 • 1 citations