Progression toward tumor cell phenotype is enhanced by overexpression of a mutant p53 tumor-suppressor gene isolated from nasopharyngeal carcinoma.

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

The Epstein-Barr Virus

1979 • 475 citations

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

1991 • 440 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Tumour promoter induces anchorage independence irreversibly

1979 • 285 citations

p53 is frequently mutated in Burkitt's lymphoma cell lines.

1991 • 259 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions.

1992 • 200 citations

Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene.

1991 • 195 citations

Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion.

1981 • 186 citations

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

1985 • 174 citations

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.

1992 • 143 citations

ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

1992 • 133 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

Viruses and cancer causal associations

1990 • 103 citations

Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

1992 • 96 citations

Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate.

1991 • 66 citations

Molecular Cloning and In Vitro Expression of a cDNA Clone for Human Cellular Tumor Antigen p53

1985 • 59 citations

Acquisition of a growth-inhibitory response to phorbol ester involves DNA damage.

1992 • 40 citations

Growth suppression mediated by transfection of p53 in Hut292DM human lung cancer cells expressing endogenous wild-type p53 protein.

1992 • 34 citations

Isolation and partial characterization of a transformation‐associated sequence from human nasopharyngeal carcinoma

1991 • 20 citations

Cloning and characterization of putative genes that specify sensitivity to neoplastic transformation by tumor promoters

1986 • 20 citations

Transfer by pro gene transfection of tumor promoter-sensitive phenotype to promotion-insensitive JB6 cells.

1988 • 14 citations