Use of Mouse JB6 Cells to Identify Molecular Targets and Novel Agents for Prevention of Carcinogenesis

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

The multistep nature of cancer

1993 • 1,872 citations

Osteopontin: a protein with diverse functions

1993 • 1,082 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Retinoic acid is a negative regulator of AP-1-responsive genes.

1991 • 542 citations

The retinoid signaling pathway: molecular and genetic analyses

1994 • 508 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.

1991 • 381 citations

Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.

1994 • 377 citations

Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion

1980 • 336 citations

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation

1994 • 318 citations

The balance between copper-zinc superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress

1991 • 302 citations

Tumour promoter induces anchorage independence irreversibly

1979 • 285 citations

Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells.

1978 • 243 citations

Anticarcinogenesis and Radiation Protection

1987 • 210 citations

AP1/ jun Function Is Differentially Induced in Promotion-Sensitive and Resistant JB6 Cells

1989 • 210 citations

Glutathione peroxidase compensates for the hypersensitivity of Cu,Zn-superoxide dismutase overproducers to oxidant stress.

1994 • 194 citations

Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion.

1981 • 186 citations

Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.

1988 • 183 citations

Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation.

1991 • 155 citations

Reduced malignancy of ras-transformed NIH 3T3 cells expressing antisense osteopontin RNA.

1994 • 146 citations

Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3

1996 • 146 citations

Inhibition of tumor promoter-induced transformation by retinoids that transrepress AP-1 without transactivating retinoic acid response element.

1996 • 139 citations

Molecular cloning of a tumor promoter‐inducible mRNA found in JB6 mouse epidermal cells: Induction is stable at high, but not at low, cell densities

1987 • 132 citations

Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA

1985 • 129 citations

Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3.

1994 • 124 citations

Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells

1988 • 119 citations

Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis

1994 • 115 citations

Specific reduction in osteopontin synthesis by antisense RNA inhibits the tumorigenicity of transformed Rat1 fibroblasts.

1994 • 99 citations

Neoplastic transformation in differentiated epithelial cell systems in vitro

1978 • 88 citations

Early superoxide dismutase-sensitive event promotes neoplastic transformation in mouse epidermal JB6 cells

1988 • 88 citations

Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors

1995 • 83 citations

Molecular Cloning of Mouse Tissue Inhibitor of Metalloproteinases-3 and Its Promoter

1995 • 63 citations

Differing modulation of protein kinase C by bryostatin 1 and phorbol esters in JB6 mouse epidermal cells.

1988 • 52 citations

Expression of antisense osteopontin RNA inhibits tumor promoter-induced neoplastic transformation of mouse JB6 epidermal cells.

1995 • 51 citations

1 alpha,25-dihydroxyvitamin D3 stimulates synthesis and secretion of nonphosphorylated osteopontin (secreted phosphoprotein 1) in mouse JB6 epidermal cells.

1991 • 51 citations

A cell culture assay for tumor‐promoter‐dependent progression toward neoplastic phenotype: Detection of tumor promoters and promotion inhibitors

1981 • 50 citations

X-ray observations of the 5 March 1979 γ-burst field

1979 • 47 citations

No point mutation of ha‐ras or p53 genes expressed in preneoplastic‐to‐neoplastic progression as modeled in mouse JB6 cell variants

1993 • 44 citations

Tumor-promoting effects of di(2-ethylhexyl)phthalate in JB6 mouse epidermal cells and mouse skin

1985 • 41 citations

Acquisition of a growth-inhibitory response to phorbol ester involves DNA damage.

1992 • 40 citations

Tumor promoter produces anchorage independence in mouse epidermal cells by an induction mechanism

1980 • 40 citations

Differential c‐jun expression in response to tumor promoters in JB6 cells sensitive or resistant to neoplastic transformation

1992 • 39 citations

A molecular genetic model of human bladder carcinogenesis.

1993 • 39 citations

Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.

1994 • 38 citations

RETINOIDS INHIBIT PROMOTER‐DEPENDENT PRENEOPLASTIC PROGRESSION IN MOUSE EPIDERMAL CELL LINES

1981 • 38 citations

Protein kinase C and its substrates in tumor promoter-sensitive and -resistant cells.

1988 • 35 citations

Phorbol diester and epidermal growth factor receptors in 12-O-tetradecanoylphorbol-13-acetate-resistant and -sensitive mouse epidermal cells.

1982 • 34 citations

Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin.

1990 • 33 citations

1 alpha,25-Dihydroxyvitamin D3 enhances 12-O-tetradecanoylphorbol-13-acetate- induced tumorigenic transformation and osteopontin expression in mouse JB6 epidermal cells.

1993 • 33 citations

Benzoyl peroxide promotion of transformation of JB6 mouse epidermal cells: inhibition by ganglioside G^T but not retinoic acid

1985 • 32 citations

Calcitriol regulation of osteopontin expression in mouse epidermal cells.

1994 • 32 citations

c‐jun and multistage carcinogenesis: Association of overexpression of introduced c‐jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter‐induced transformation

1995 • 31 citations

C-JUN/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells.

1995 • 29 citations

Differential expression of an 80-kDa protein kinase C substrate in preneoplastic and neoplastic mouse JB6 cells.

1989 • 28 citations

Differential transformation efficiency but not AP-1 induction under anchorage-dependent and -independent conditions

1994 • 27 citations

The effect of active oxygen generated by xanthine/xanthine oxidase on genes and signal transduction in mouse epidermal JB6 cells

1995 • 26 citations

Constitutive and phorbol‐myristate‐acetate regulated antioxidant defense of mouse epidermal JB6 cells

1989 • 25 citations

Specific binding of transforming growth factor correlates with promotion of anchorage independence in EGF receptorless mouse JB6 cells

1981 • 23 citations

12‐O‐tetradecanoylphorbol‐13‐acetate—induced levels of ap‐1 proteins: a 46‐kda protein immunoprecipitated by anti‐fra‐1 and induced in promotion‐resistant but not promotion‐sensitive JB6 cells

1992 • 22 citations

Public Health: 'Natural' Cancer Prevention Trial Halted

1996 • 22 citations

Extracellular calcium requirement for promotion of transformation in JB6 cells.

1986 • 20 citations

Enhancement of anchorage-independent growth in JB6 cells exposed to 60 hertz magnetic fields

1994 • 20 citations

:'Natural' Cancer Prevention Trial Halted

1996 • 20 citations

Preferential oxidation of cell surface sialic acid by periodate leads to promotion of transformation in JB6 cells

1984 • 19 citations

Induction of anchorage-independent growth of JB6 mouse epidermal cells by 1 alpha,25-dihydroxyvitamin D3.

1986 • 19 citations

Preferential primary‐response gene expression in promotion‐resistant versus promotion‐sensitive JB6 cells

1994 • 18 citations

Possible involvemnt of a lanthanide-sensitive protein kinase C substrate in lanthanide promotion of neoplastic transformation

1986 • 16 citations

Oncogenic signal-induced ability to enter S phase in the absence of anchorage is the mechanism for the growth of transformed NRK cells in soft agar.

1992 • 16 citations

Genes and signal transduction in tumor promotion: conclusions from studies with promoter resistant variants of JB-6 mouse epidermal cells.

1985 • 14 citations

Cellular and molecular aspects of the multistage progression of mammary carcinogenesis in humans and rats.

1993 • 13 citations

Effects of transforming growth factor beta on the anchorage-independent growth of murine epithelial JB6 cells.

1991 • 12 citations

Synergistic inhibition of phorbol ester-induced transformation of JB6 cells by transforming growth factor-beta and retinoic acid.

1991 • 11 citations

Differential cytotoxicity in mouse epidermal JB6 cells: A potential mechanism for oxidant tumor promotion

1994 • 10 citations

Calcitriol regulation of osteopontin expression in mouse epidermal cells

1994 • 10 citations

Correlation of the ability of retinoids to inhibit promoter-induced anchorage-independent growth of JB6 mouse epidermal cells with their activation of retinoic acid receptor γ

1993 • 10 citations

Comparison of mouse pro-1 and pro-2 transfectants for responses to tumor promoters and antipromoters.

1988 • 9 citations

JB6 murine epidermal cell lines sensitive and resistant to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation exhibit differential arachidonic acid metabolism in response to TPA and the calcium ionophore A23187

1992 • 7 citations

Genes and membrane signals involved in neoplastic transformation.

1985 • 6 citations

Induction of anchorage-indepdent growth of mouse JB6 cells by chlora toxin

1987 • 6 citations

Differential Effects of TPA and Pristane on Gene Expression and Transformation in Mouse Epidermal Cells

1993 • 5 citations

Membrane and genetic events in tumor promotion: studies with promoter resistant variants of JB6 cells.

1983 • 5 citations

STATUS OF THE MDM-2 AND WAF-1 GENES IN MOUSE EPIDERMAL JB6 VARIANTS HARBORING WILD-TYPE P53 - A P53-INDEPENDENT INDUCTION OF WAF-1

1995 • 4 citations

Differential induction of 15 and 16 kDa nuclear proteins in promotion sensitive and promotion resistant mouse JB6 cells.

1992 • 3 citations

Implication of Superoxide Radical Anion in Promotion of Neoplastic Transformation in Mouse JB6 Cells by TPA

1987 • 3 citations

Carba-prostacydin inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced transformation in sensitive murine epidermal JB6 cells

1992 • 3 citations

Differential Susceptibility of Morphologically TPA-Resistant and -Sensitive Balb/c 3T3 Variants to TPA-Induced Cell Transformation: Relationship to Induction of Membrane Ruffling.

1994 • 2 citations