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1988 • 290 citations

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1991 • 282 citations

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1988 • 281 citations

The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat

1987 • 281 citations

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1991 • 279 citations

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1983 • 266 citations

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1989 • 242 citations

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1989 • 240 citations

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1991 • 238 citations

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1982 • 232 citations

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1985 • 231 citations

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1988 • 229 citations

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1987 • 226 citations

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1984 • 226 citations

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1991 • 226 citations

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1984 • 219 citations

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1989 • 218 citations

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1985 • 213 citations

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1989 • 211 citations

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1989 • 211 citations

The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

1993 • 211 citations

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1982 • 209 citations

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1977 • 209 citations

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1977 • 206 citations

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1988 • 205 citations

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1987 • 205 citations

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1991 • 204 citations

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1989 • 204 citations

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1988 • 204 citations

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1971 • 195 citations

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1990 • 195 citations

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1987 • 194 citations

Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis

1989 • 193 citations

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1989 • 193 citations

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1992 • 192 citations

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1983 • 191 citations

Pharmacologic characterization of nicotine-induced conditioned place preference

1985 • 191 citations

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1987 • 189 citations

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1972 • 186 citations

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1989 • 184 citations

Microinjections of Sch-23390 into the ventral tegmental area and substantia nigra pars reticulata attenuate the development of sensitization to the locomotor activating effects of systematic amphetamine

1989 • 182 citations

Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.

1980 • 182 citations

Repeated cocaine administration induces behavioral sensitization and corresponding decreased extracellular dopamine responses in caudate and accumbens

1992 • 181 citations

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1984 • 181 citations

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1985 • 180 citations

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1975 • 180 citations

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1990 • 180 citations

Development of both conditioning and sensitization of the behavioral activating effects of amphetamine is blocked by the non-competitive NMDA receptor antagonist, MK-801

1993 • 180 citations

Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: The involvement of the nucleus accumbens

1993 • 179 citations

Stimulant effects of enkephalin microinjection into the dopaminergic A10 area

1979 • 178 citations

Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by Rhesus monkeys

1986 • 177 citations

Ethanol Enhances the Release of Dopamine and Serotonin in the Nucleus Accumbens of HAD and LAD Lines of Rats

1992 • 177 citations

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1992 • 177 citations

5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

1989 • 176 citations

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1987 • 176 citations

Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys.

1990 • 176 citations

The organization of midbrain projections to the ventral striatum in the primate

1994 • 173 citations

Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections.

1991 • 173 citations

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1991 • 172 citations

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1973 • 172 citations

Drug level of d- and l-amphetamine during intravenous self-administration

1974 • 172 citations

Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats

1982 • 171 citations

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1989 • 171 citations

Effects of antipsychotic drugs on latent inhibition: sensitivity and specificity of an animal behavioral model of clinical drug action

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Mesencephalic dopaminergic unit activity in the behaviorally conditioned rat

1981 • 170 citations

Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

1987 • 169 citations

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1985 • 169 citations

Predicting dependence liability of stimulant and depressant drugs

1977 • 169 citations

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1991 • 168 citations

Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats

1994 • 167 citations

Decreased resistance to extinction after haloperidol: Implications for the role of dopamine in reinforcement

1979 • 166 citations

Scheduled eating increases dopamine release in the nucleus accumbens of food-deprived rats as assessed with on-line brain dialysis

1988 • 166 citations

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1990 • 162 citations

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1992 • 160 citations

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1979 • 159 citations

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1981 • 157 citations

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1989 • 156 citations

Motivational effects of opioids: influence of D-1 versus D-2 receptor antagonists

1988 • 156 citations

Dopamine transmission increases in the nucleus accumbens of male rats during their first exposure to sexually receptive female rats

1993 • 156 citations

Dopamine D1 and D2 mediation of the discriminative stimulus properties ofd-amphetamine and cocaine

1991 • 156 citations

Pimozide decreases the positive reinforcing effect of sham fed sucrose in the rat

1985 • 155 citations

Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats

1991 • 155 citations

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1994 • 154 citations

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1991 • 154 citations

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1979 • 153 citations

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1992 • 153 citations

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1962 • 153 citations

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1991 • 153 citations

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1992 • 152 citations

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1987 • 152 citations

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1989 • 151 citations

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1993 • 151 citations

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1983 • 150 citations

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1987 • 150 citations

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1977 • 149 citations

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1986 • 148 citations

Toward understanding ethanol's capacity to be reinforcing: A conditioned place preference following injections of ethanol

1985 • 148 citations

Localization of Nigral Dopamine-Sensitive Adenylate Cyclase on Neurons Originating from the Corpus Striatum

1977 • 147 citations

Dopaminergic involvement in activational aspects of motivation: Effects of haloperidol on schedule-induced activity, feeding, and foraging in rats

1988 • 146 citations

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1981 • 146 citations

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1993 • 145 citations

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1976 • 144 citations

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1989 • 144 citations

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1991 • 144 citations

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1961 • 144 citations

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1973 • 143 citations

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1979 • 142 citations

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1987 • 142 citations

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1992 • 141 citations

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1987 • 141 citations

Subchronic cocaine treatment enhances cocaine-induced dopamine efflux, studied by in vivo intracerebral dialysis

1989 • 141 citations

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1990 • 139 citations

The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus

1981 • 137 citations

Neuropharmacological assessment of cocaine self-administration into the medial prefrontal cortex

1986 • 136 citations

The effects of Δ9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study

1988 • 136 citations

Development and expression of sensitization to cocaine's reinforcing properties: role of NMDA receptors

1993 • 135 citations

Correlation of dopamine release in the nucleus accumbens with masculine sexual behavior in rats

1990 • 134 citations

Behavioral and neurochemical sensitization following cocaine self-administration

1994 • 133 citations

Emotional but not physical stress enhances intravenous cocaine self-administration in drug-naive rats

1993 • 133 citations

Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes.

1991 • 133 citations

The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food

1989 • 131 citations

Electrical stimulation of reward sites in the ventral tegmental area increases dopamine transmission in the nucleus accumbens of the rat

1993 • 130 citations

An evaluation of response rate as a measure of rewarding intracranial stimulation.

1962 • 130 citations

Role of repeated exposure to morphine in determining its affective properties: place and taste conditioning studies in rats

1991 • 129 citations

Evidence for the rewarding effects of ethanol using the conditioned place preference method

1990 • 128 citations

(D-Ala2)deltorphin II: D1-dependent stereotypies and stimulation of dopamine release in the nucleus accumbens

1991 • 127 citations

Responses of monkey midbrain dopamine neurons during delayed alternation performance

1991 • 126 citations

On the preferential release of dopamine in the nucleus accumbens by amphetamine: further evidence obtained by vertically implanted concentric dialysis probes

1993 • 126 citations

Increased dopamine release in the nucleus accumbens of copulating male rats as evidenced by in vivo voltammetry

1990 • 126 citations

Apparent synaptic dopamine deficiency induced by withdrawal from chronic cocaine treatment

1991 • 126 citations

Motivational properties of ethanol in naive rats as studied by place conditioning

1983 • 126 citations

Amphetamine-induced disruptions of latent inhibition are reinforcer mediated: implications for animal models of schizophrenic attentional dysfunction

1994 • 124 citations

Aversive Conditioning by Ethanol in the Rat

1970 • 124 citations

Behavioural and pharmacological studies on morphine-induced excitation of rats. Possible relation to brain catecholamines

1973 • 124 citations

Heroin self-administration in rats under a progressive ratio schedule of reinforcement

1993 • 122 citations

A10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment

1990 • 122 citations

Isolation rearing enhances the locomotor response to cocaine and a novel environment, but impairs the intravenous self-administration of cocaine

1994 • 121 citations

Differential effects of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine.

1992 • 120 citations

Functional consequences of acute cocaine treatment depend on route of administration

1993 • 120 citations

Dopamine and preparatory behavior: I. Effects of pimozide.

1987 • 120 citations

Subchronic methamphetamine treatment enhances methamphetamine- or cocaine-induced dopamine efflux in vivo

1989 • 119 citations

The Psychobiology of Reinforcers

1992 • 118 citations

Dopaminergic substrates of cocaine-induced place conditioning

1986 • 116 citations

The effect of pimozide on the establishment of conditioned reinforcement

1980 • 115 citations

Novelty-induced place preference behavior in rats: Effects of opiate and dopaminergic drugs

1989 • 115 citations

6-Hydroxydopamine lesions of the medial prefrontal cortex fail to influence intravenous self-administration of cocaine

1986 • 115 citations

A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior

1988 • 114 citations

A comparison of pentobarbital and cocaine self-administration in rhesus monkeys: effects of dose and fixed-ratio parameter.

1971 • 114 citations

Genetic analysis of avoidance, maze, and wheel-running behaviors in the mouse.

1972 • 114 citations

Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

1994 • 113 citations

Increased extracellular dopamine in the nucleus accumbens of the rat elicited by a conditional stimulus for food: an electrochemical study

1993 • 112 citations

Social isolation attenuates rat forebrain 5-HT release induced by KCl stimulation and exposure to a novel environment

1993 • 112 citations

Self‐Stimulation and Drug Reward Mechanisms

1992 • 111 citations

Effects of repeated methamphetamine administration on methamphetamine self-administration in rhesus monkeys

1984 • 111 citations

The potentiation of conditioned reinforcement by psychomotor stimulant drugs. A Test of Hill's Hypothesis

1975 • 111 citations

Caffeine exposure sensitizes rats to the reinforcing effects of cocaine

1991 • 111 citations

Endogenous κ-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release

1994 • 110 citations

Stimuli associated with drug injections as events that control behavior.

1975 • 110 citations

Effects of pimozide on lever pressing behavior maintained on an intermittent reinforcement schedule

1980 • 110 citations

A new device for administering placebo alcohol

1984 • 109 citations

Effects of nucleus accumbens amphetamine on lateral hypothalamic brain stimulation reward

1988 • 109 citations

Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum

1990 • 108 citations

Enhancement of dopamine actions on rat nucleus accumbens neurones in vitro after methamphetamine pre‐treatment.

1989 • 108 citations

Withdrawal of repeated cocaine decreases autoradlographic [3H]mazindol-labelling of dopamine transporter In rat nucleus aecumbens

1991 • 108 citations

Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat

1987 • 108 citations

Increased dopamine release in vivo in nucleus accumbens and caudate nucleus of the rat during drinking: A microdialysis study

1992 • 107 citations

A functional hypothesis concerning the striatal matrix and patches: Mediation of SR memory and reward

1989 • 106 citations

Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain.

1975 • 106 citations

Separation of inhibiting and stimulating effects of morphine on self-stimulation behaviour by intracerebral microinjections

1976 • 106 citations

The long-term effects of repeated amphetamine treatment in vivo on amphetamine, KCl and electrical stimulation evoked striatal dopamine release in vitro

1988 • 105 citations

Nalorphine-induced changes in morphine self-administration in rhesus monkeys.

1971 • 105 citations

Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference

1992 • 104 citations

Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens

1992 • 104 citations

Concomitant sensitization of amphetamine-induced behavioral stimulation and in vivo dopamine release from rat caudate nucleus

1991 • 104 citations

Cholinergic and dopaminergic modulation of potassium conductances in neostriatal neurons.

1993 • 103 citations

Persistence of chronic morphine effects upon activity in rats 8 months after ceasing the treatment

1975 • 103 citations

Discriminative stimulus properties of cocaine and d-amphetamine, and antagonism by haloperidol: A comparative study

1978 • 103 citations

Drugs as Reinforcers

1978 • 102 citations

An experimental framework for evaluation of dependence liability of various types of drugs in monkeys.

1973 • 101 citations

The effects of pimozide on the consumption of a palatable saccharin-glucose solution in the rat

1981 • 101 citations

Characterization of the effects of cocaine and GBR 12909, a dopamine uptake inhibitor, on behavior in the squirrel monkey.

1991 • 100 citations

Chronic cocaine alters limbic extracellular dopamine. Neurochemical basis for addiction

1992 • 99 citations

Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine

1989 • 99 citations

Aversion instead of preference learning indicated by nicotine place conditioning in rats

1990 • 98 citations

Evidence for involvement of both D1 and D2 receptors in maintaining cocaine self-administration

1991 • 97 citations

Effects of dopamine receptor antagonists on sucrose consumption and preference

1989 • 97 citations

D1 receptor blockade stereospecifically impairs the acquisition of drug-conditioned place preference and place aversion

1994 • 97 citations

Drug-induced reinstatement of amphetamine self-administration behaviour in monkeys.

1973 • 97 citations

Postcocaine depression and sensitization of brain-stimulation reward: Analysis of reinforcement and performance effects

1990 • 97 citations

Ethanol-like discriminative stimulus effects of non- competitive n-methyl-d-aspartate antagonists

1991 • 97 citations

The cholinergic innervation of the rat substantia nigra: a light and electron microscopic immunohistochemical study

1988 • 97 citations

increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis

1989 • 96 citations

Dopaminergic neurons: Effect of acute and chronic morphine administration on single cell activity and transmitter metabolism

1978 • 95 citations

The effects of selective dopamine D1 or D2 receptor antagonists on the establishment of agonist-induced place conditioning in rats

1989 • 95 citations

Effect of haloperidol on (+)-amphetamine self-administration

1975 • 95 citations

Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine

1989 • 95 citations

Morphine: Conditioned Increases in Self-Administration in Rhesus Monkeys

1969 • 95 citations

Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration

1992 • 93 citations

Cocaine-induced conditioned locomotion: Absence of associated increases in dopamine release

1992 • 92 citations

Isolation rearing impairs the reinforcing efficacy of intravenous cocaine or intra-accumbensd-amphetamine: impaired response to intra-accumbens D1 and D2/D3 dopamine receptor antagonists

1994 • 92 citations

Long lasting changes in morphine‐induced mesolimbic dopamine release after chronic morphine exposure

1993 • 92 citations

Localized intracaudate dopamine D2 receptor activation during the post-training period improves memory for visual or olfactory conditioned emotional responses in rats

1991 • 92 citations

Long-term sensitization to the excitatory effects of morphine

1983 • 92 citations

Reduced Clearance of Exogenous Dopamine in Rat Nucleus Accumbens, but Not in Dorsal Striatum, Following Cocaine Challenge in Rats Withdrawn from Repeated Cocaine Administration

1993 • 90 citations

Discriminative stimulus properties of amphetamine and structurally related phenalkylamines

1986 • 90 citations

Influence of dopaminergic and serotonergic neurons on intravenous ethanol self-administration in the rat

1992 • 89 citations

The Anxiogenic β‐Carboline FG 7142 Selectively Increases Dopamine Release in Rat Prefrontal Cortex as Measured by Microdialysis

1991 • 88 citations

The cytology of dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area of the rat: A light- and electron-microscopic study

1983 • 88 citations

Second-Order Schedules of Drug Injection

1987 • 88 citations

Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo

1990 • 87 citations

Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective ? and ? opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes

1988 • 87 citations

Place conditioning in a three- or four-choice apparatus: Role of stimulus novelty in drug-induced place conditioning.

1992 • 87 citations

Assessment of ethanol's hedonic effects in mice selectively bred for sensitivity to ethanol-induced hypothermia

1991 • 87 citations

Robustness of G protein changes in cocaine sensitization shown with immunoblotting

1993 • 86 citations

Effects of 6-OHDA lesions of the central medial nucleus accumbens on rat intravenous morphine self-administration

1985 • 86 citations

Drugs of abuse: biochemical surrogates of specific aspects of natural reward?

1993 • 86 citations

Monoamine mediation of the morphine‐induced activation of mice

1972 • 86 citations

Reduction of dopamine utilization in the prefrontal cortex but not in the nucleus accumbens after selective destruction of noradrenergic fibers innervating the ventral tegmental area in the rat

1982 • 86 citations

Modulation of morphine-induced sensitization by endogenous κ opioid systems in the rat

1993 • 86 citations

Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys

1987 • 85 citations

Increases in extracellular dopamine levels and locomotor activity after direct infusion of phencyclidine into the nucleus accumbens

1992 • 85 citations

Place conditioning with morphine and phencyclidine: Dose dependent effects

1985 • 84 citations

Opioid receptor subtypes associated with ventral tegmental facilitation of lateral hypothalamic brain stimulation reward

1987 • 84 citations

Lack of evidence for an involvement of nucleus accumbens dopamine D1 receptors in the initiation of heroin self-administration in the rat

1994 • 83 citations

Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. II. Involvement of the mesolimbic dopamine system.

1985 • 83 citations

Apparent absence of nicotine-induced conditioned place preference in rats

1987 • 83 citations

Conditioned locomotor activity but not conditioned place preference following intra-accumbens infusions of cocaine

1992 • 82 citations

Post-training dopamine receptor agonists and antagonists affect memory storage in mice irrespective of their selectivity for D1 or D2 receptors

1991 • 82 citations

Failure to establish a conditioned place preference with ethanol in rats

1985 • 81 citations

Spatial aversion conditioning with ethanol

1981 • 81 citations

5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat

1993 • 81 citations

Chronic neuroleptic treatment and mesolimbic dopamine denervation induce behavioural supersensitivity to opiates

1985 • 80 citations

In vivo voltammetry: Some methodological considerations

1986 • 80 citations

Amphetamine withdrawal: A behavioral evaluation

1986 • 79 citations

Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration

1988 • 78 citations

Low doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat

1985 • 78 citations

Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method

1993 • 77 citations

The dopamine hypothesis of opiate reward challenged

1987 • 77 citations

Conditioned Drug Effects on Spatial Preference: Critical Evaluation

2003 • 77 citations

Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists

1991 • 76 citations

The actions of opiates in the rat substantia nigra: An electrophysiological analysis

1983 • 76 citations

Effects of dopaminergic agents on alcohol consumption by rats in a limited access paradigm

1990 • 76 citations

Place conditioning in a three- or four-choice apparatus: Role of stimulus novelty in drug-induced place conditioning.

1992 • 75 citations

The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue

1988 • 75 citations

Does amphetamine preferentially increase the extracellular concentration of dopamine in the mesolimbic system of freely moving rats?

1990 • 75 citations

The Neurobiology of Cocaine: Cellular and Molecular Mechanisms

1995 • 75 citations

On the role of ascending dopamine systems in the control of voluntary ethanol intake and ethanol intoxication

1979 • 74 citations

Drug Motivation and Abuse: A Neurobiological Perspective

1992 • 74 citations

Effects of the neuroleptic α-flupenthixol on latent inhibition in aversively- and appetitively-motivated paradigms: evidence for dopamine-reinforcer interactions

1994 • 73 citations

Microinjection of sulpiride into the nucleus accumbens increases ethanol drinking in alcohol-preferring (P) rats.

1991 • 73 citations

Effect of pimozide on home cage ethanol drinking in the rat: Dependence on drinking session length

1986 • 73 citations

MK801 attenuates behavioural adaptation to chronic nicotine administration in rats

1992 • 72 citations

Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area

1992 • 72 citations

Changes in response rates and reinforcement thresholds for intracranial self-stimulation during morphine withdrawal

1986 • 72 citations

Chronic d-amphetamine in nucleus accumbens: Lack of tolerance or reverse tolerance of locomotor activity

1981 • 72 citations

Phencyclidine (PCP) injected in the nucleus accumbens increases extracellular dopamine and serotonin as measured by microdialysis

1988 • 71 citations

Pre-exposure to amphetamine but not nicotine sensitizes rats to the motor activating effect of cocaine

1991 • 70 citations

Pharmacologically induced cessation of burst activity in nigral dopamine neurons: Significance for the terminal dopamine efflux

1994 • 70 citations

Effects of continuous infusions of SCH 23390 on cocaine- or food-maintained behavior in rhesus monkeys

1990 • 70 citations

Drug Self-Administration: An Analysis of the Reinforcing Effects of Drugs

1978 • 68 citations

Factors regulating drug cue sensitivity: The effect of training dose in fentanyl-saline discrimination

1980 • 68 citations

Self-administration of GBR 12909 on a fixed ratio and progressive ratio schedule in rats

1993 • 67 citations

Reinforcing properties of some local anesthetics in rhesus monkeys

1979 • 67 citations

Cocaine withdrawal produces behavioral disruptions in rats

1987 • 67 citations

Withdrawal from morphine or amphetamine: different effects on dopamine in the ventral-medial striatum studied with microdialysis

1994 • 66 citations

Long-term amphetamine treatment attenuates or reverses the depression of neuronal activity produced by dopamine agonists in the ventral tegmental area

1984 • 66 citations

Measuring morphine's capacity to establish a place preference

1989 • 65 citations

Chlorpromazine effects on cocaine-reinforced responding in rhesus monkeys: reciprocal modification of rate-altering effects of the drugs.

1980 • 65 citations

Chronic cocaine administration is associated with behavioral sensitization and time-dependent changes in striatal dopamine transporter binding.

1994 • 64 citations

Effects of antipsychotic compounds in rhesus monkeys given a choice between cocaine and food

1981 • 63 citations

Brain locations controlling the behavioral effects of chronic amphetamine intoxication

1980 • 63 citations

The effect of microinjections of amphetamine into the neostriatum and the nucleus accumbens on self-stimulation behaviour

1975 • 62 citations

Conditioned place aversion mediated by orally self-administered ethanol in the rat

1986 • 62 citations

Role of vesicular dopamine in the in vivo stimulation of striatal dopamine transmission by amphetamine: Evidence from microdialysis and Fos immunohistochemistry

1995 • 62 citations

Second-order schedules of drug injection

1975 • 62 citations

One injection of cocaine produces a long-lasting increase in [3H]-dopamine release

1987 • 61 citations

Lack of effect of dopamine receptor blockade on voluntary ethanol consumption in rats

1982 • 59 citations

The effects of pimozide during pairing on the transfer of classical conditioning to an operant discrimination

1981 • 58 citations

Anxiogenic properties of cocaine withdrawal

1987 • 58 citations

Changes in Brain Dopamine Metabolism During Withdrawal from Chronic Oral Self-administration of Morphine, and in Response to a Morphine Challenge in the Withdrawn State

1988 • 57 citations

Environment-specific enhancement of the hyperactivity induced by systemic or intra-VTA morphine injections in rats preexposed to amphetamine

1987 • 57 citations

Effects of pimozide on sucrose consumption and preference

1987 • 57 citations

Drug Discrimination: Methods of Manipulation, Measurement, and Analysis

1987 • 57 citations

Mesoaccumbens dopamine-opiate interactions in the control over behaviour by a conditioned reinforcer

1994 • 57 citations

Environmental influences on behavioural sensitization to the dopamine agonist quinpirole

1992 • 56 citations

The use of extinction to investigate the nature of neuroleptic-induced avoidance deficits

1980 • 55 citations

Genetic approaches to studying drug abuse: Correlates of drug self-administration

1990 • 55 citations

Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin

1985 • 54 citations

Enhancement of dopamine release from striatal slices of rats that were subchronically treated with methamphetamine

1988 • 54 citations

Rapid Induction of Conditioned Opiate Withdrawal in the Rat

1993 • 54 citations

Alcohol-induced conditioned aversion: Genotypic specificity in mice (Mus musculus).

1975 • 54 citations

Dopaminergic D-1 receptors: essential role in morphine-induced hypermotility

1987 • 53 citations

Tolerance to the reinforcing effects of cocaine

1992 • 53 citations

THE ACQUISITION OF RESPONDING WITH CONDITIONED REINFORCEMENT: EFFECTS OF COCAINE, (+)‐AMPHETAMINE AND PIPRADROL

1981 • 53 citations

Hedonic reactivity to sucrose in rats: Modification by pimozide

1986 • 53 citations

Ethanol drinking following 6-OHDA lesions of nucleus accumbens and tuberculum olfactorium of the rat

1991 • 52 citations

Role of reward and enhancement of conditioned reward in persistence of responding for cocaine

1990 • 50 citations

Substantia nigra as a site of origin of dopamine-dependent motor syndromes induced by stimulation of μ and δ opioid receptors

1989 • 50 citations

Dopamine and conditioned reinforcement

1991 • 50 citations

Use of microdialysis to measure brain noradrenergic receptor function in vivo

1988 • 49 citations

Nigral dopamine autoreceptors are exclusively of the D2 type: Quantitative autoradiography of [125I]iodosulpride and [125I]SCH 23982 in adjacent brain sections

1988 • 47 citations

Current concepts of addiction.

1992 • 46 citations

Chronic treatment with five different neuroleptics elicits behavioral supersensitivity to opiate infusion into the nucleus accumbens

1986 • 45 citations

Naloxone as a negative reinforcer in rhesus monkeys: effects of dose, schedule, and narcotic regimen.

1975 • 44 citations

D1 agonist-induced excitation of substantia nigra pars reticulata neurons: mediation by D1 receptors on striatonigral terminals via a pertussis toxin-sensitive coupling pathway

1994 • 43 citations

Fentanyl and apomorphine: Asymmetrical generalization of discriminative stimulus properties

1976 • 43 citations

Bidirectional microdialysis in vivo shows differential dopaminergic potency of cocaine, procaine and lidocaine in the nucleus accumbens using capillary electrophoresis for calibration of drug outward diffusion

1991 • 40 citations

Effect of chlorpromazine and some of its metabolites on synthesis and turnover of catecholamines formed from 14C-tyrosine in mouse brain

1972 • 40 citations

Morphine withdrawal produces differential effects on the rate of lever-pressing for brain self-stimulation in the hypothalamus and midbrain in rats

1983 • 39 citations

Conditioned place aversion produced by FG 7142 is attenuated by haloperidol

1989 • 39 citations

Mesolimbic dopamine: An analysis of its role in motivated behavior

1993 • 39 citations

Evidence for the role of dopamine D1 receptors in morphine induced stereotypic behavior

1989 • 37 citations

Morphine suppression of substantia nigra zona reticulata neurons in the rat: Implicated role for a novel striatonigral feedback mechanism

1979 • 36 citations

D-Amphetamine-like stimulus properties are produced by morphine injections into the ventral tegmental area but not into the nucleus accumbens

1993 • 36 citations

Reward-dependent suppression or facilitation of consummatory behaviour by raclopride

1991 • 36 citations

Acquisition and recovery of tolerance to the discriminative stimulus properties of cocaine

1984 • 36 citations

Behavioural sensitization in 6-hydroxydopamine lesioned rats involves the dopamine signal transduction: Changes in DARPP-32 phosphorylation

1994 • 35 citations

Effect of reserpine, alpha-methyl-p-tyrosine, p-chlorophenylalanine and pargyline on levorphanol-induced running activity in mice.

1969 • 35 citations

Dose and physical dependence as factors in the self-administration of morphine by rats

1979 • 35 citations

Nucleus accumbens opiate-dopamine interactions and locomotor activation in the rat: Evidence for a pre-synaptic locus

1987 • 34 citations

In Vivo Measurement of Extracellular Cyclic AMP in the Brain: Use in Studies of β‐Adrenoceptor Function in Nonanesthetized Rats

1990 • 34 citations

Effects of pimozide on the hedonic properties of sucrose: Analysis by the taste reactivity test

1991 • 33 citations

Effect of L-fucose on brain protein metabolism and retention of a learned behavior in rats

1980 • 33 citations

Suppression or facilitation of operant behaviour by raclopride dependent on concentration of sucrose reward

1991 • 32 citations

Animal models of drug self-administration

1992 • 32 citations

Selective D1 and D2 dopamine antagonists decrease response rates of food-maintained behavior and reduce the discriminative stimulus produced by heroin

1990 • 30 citations

Controlling interindividual differences in the unconditioned response to amphetamine in the study of environment-dependent sensitization

1993 • 29 citations

Role played by catechol and indolamines in the central actions of reserpine after monoaminoxidase inhibition

1965 • 29 citations

???Priming??? to dopamine agonist-induced contralateral turning as a model of non-associative sensitization to the expression of the post-synaptic dopamine message

1993 • 28 citations

PCP and conditioned place preferences

1989 • 28 citations

Time-, schedule-, and reinforcer-dependent effects of pimozide and amphetamine

1991 • 28 citations

Studies on the regulation of sensitivity to the narcotic cue

1978 • 28 citations

Pharmacological analysis of the apomorphine discriminative stimulus in rhesus monkeys.

1987 • 26 citations

A Neuroanatomical and Neuropharmacological Analysis of Basal Ganglia Output

1984 • 25 citations

Conditioning compensates the neglect due to unilateral 6-OHDA lesions of substantia nigra in rats

1979 • 24 citations

8-Hydroxy-2-(DI-N-propylamino)tetralin increases the activity of adenylate cyclase in the hippocampus of freely-moving rats

1991 • 24 citations

Evidence that the increased anxiety detected in the elevated plus-maze during chlordiazepoxide withdrawal is not due to enhanced noradrenergic activity

1989 • 23 citations

Effect of propranolol, d-amphetamine and caffeine on ethanol as a discriminative cue

1974 • 23 citations

Tolerance, withdrawal, and supersensitivity to dopamine mediated cues in a drug-drug discrimination

1992 • 22 citations

Place-aversion conditioned by phencyclidine in rats: development of tolerance and pharmacologic antagonism.

1985 • 20 citations

Combined Microdialysis and Fos Immunohistochemistry for the Estimation of Dopamine Neurotransmission in the Rat Caudate‐Putamen

1992 • 20 citations

Morphine-Induced Modification of the Functional Properties of Ventral Tegmental Area Neurons in Conscious Rat

1988 • 19 citations

Response suppression on a mixed schedule of reinforcement during alcohol withdrawal

1976 • 19 citations

Tolerance to the discriminative stimulus effects of ethanol

1990 • 19 citations

Sensitivity to the narcotic cue in non-dependent, morphine-dependent and post-dependent rats

1986 • 16 citations

Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine

1992 • 16 citations

Activation of postsynaptic striatal dopamine receptors, monitored by efflux of cAMP in vivo

1990 • 14 citations

Effect of fenfluramine and nicotine upon a stimulant-depressant continuum

1981 • 12 citations

Effects of cocaine, chlordiazepoxide, and chlorpromazine on responding of squirrel monkeys under second-order schedules of IM cocaine injection or food presentation

1983 • 9 citations

Oscillation of interspike interval length in substantia nigra dopamine neurons: Effects of nicotine and the dopaminergic D₂ agonist LY 163502 on electrophysiological activity

1992 • 9 citations

Searching for the hidden order in chaos. Commentary on Kalivas et al. ???The pharmacology and neural circuitry of sensitization to psychostimulants???

1993 • 7 citations

Deleted Work

1955 • 0 citations