Chronic treatment with five different neuroleptics elicits behavioral supersensitivity to opiate infusion into the nucleus accumbens

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

Brain dopamine receptors.

1980 • 1,878 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Psychopharmacology: A Generation of Progress

1979 • 1,101 citations

An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal‐projection (prefrontal) cortex in the rat

1979 • 787 citations

Heterogeneity of Psychiatric Diagnosis in Treated Opiate Addicts

1982 • 580 citations

Autoradiographic localization of opiate receptors in rat brain. II. The brain stem

1977 • 573 citations

Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon

1977 • 566 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

1976 • 466 citations

Enkephalin may mediate euphoria and drive-reduction reward

1977 • 450 citations

Diagnosis and Symptoms of Depression in Opiate Addicts

1982 • 419 citations

Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity.

1983 • 355 citations

The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat

1979 • 354 citations

Reinforcing effects of morphine microinjection into the ventral tegmental area

1980 • 334 citations

Enkephalin receptors on dopaminergic neurones in rat striatum

1977 • 312 citations

Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks.

1983 • 286 citations

Determination of methionine enkephalin in discrete regions of rat brain

1977 • 280 citations

Rat striatal methionine-enkephalin content after chronic treatment with cataleptogenic and noncataleptogenic antischizophrenic drugs.

1978 • 276 citations

Reinforcing effects of morphine in the nucleus accumbens

1982 • 254 citations

Reinforcing effects of brain microinjections of morphine revealed by conditioned place preference

1982 • 238 citations

Self-administration of methionine enkephalin into the nucleus accumbens

1984 • 238 citations

Neuroanatomical focus for morphine and enkaphalin-induced hypermotility

1977 • 209 citations

Interactions between d-Ala-Met-enkephalin, A10 dopaminergic neurones, and spontaneous behaviour in the rat

1980 • 203 citations

Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.

1980 • 182 citations

Stimulant effects of enkephalin microinjection into the dopaminergic A10 area

1979 • 178 citations

Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons.

1977 • 149 citations

The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus

1981 • 137 citations

Pharmacologically Induced Behavioural Supersensitivity to Apomorphine

1973 • 136 citations

Chronic treatment with haloperidol accelerates the biosynthesis of enkephalins in rat striatum

1979 • 128 citations

A topographic localization of enkephalin on the dopamine neurons of the rat substantia nigra and ventral tegmental area demonstrated by combined histofluorescence-immunocytochemistry

1980 • 121 citations

Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.

1984 • 117 citations

Regulation of methionine-enkephalin precursor messenger RNA in rat striatum by haloperidol and lithium

1983 • 110 citations

Reward produced by microinjection of (d-Ala2),Met5-enkephalinamide into the ventral tegmental area

1982 • 100 citations

Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra

1984 • 97 citations

Dopaminergic mediation of reward produced by direct injection of enkephalin into the ventral tegmental area of the rat

1983 • 95 citations

Single cortical neurones have axon collaterals to ipsilateral and contralateral cortex in fetal and adult primates

1982 • 94 citations

Striatal met-enkephalin concentration increases following nigrostriatal denervation

1983 • 92 citations

Ventral tegmental site of opiate reward: Antagonism by a hydrophilic opiate receptor blocker

1983 • 91 citations

Increase in brain 125I-cholecystokinin (CCK) receptor binding following chronic haloperidol treatment, intracisternal 6-hydroxydopamine or ventral tegmental lesions

1983 • 89 citations

Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain

1983 • 87 citations

Brain endorphins and the sense of well-being: a psychobiological hypothesis.

1978 • 85 citations

Non-DA prefronto-cortical efferents modulate D1 receptors in the nucleus accumbens

1984 • 84 citations

Non-dopaminergic fibres may regulate dopamine-sensitive adenylate cyclase in the prefrontal cortex and nucleus accumbens

1982 • 82 citations

Chronic neuroleptic treatment and mesolimbic dopamine denervation induce behavioural supersensitivity to opiates

1985 • 80 citations

A behavioural and biochemical comparison of dopamine receptor blockade produced by haloperidol with that produced by substituted benzamide drugs

1978 • 79 citations

Cholecystokinin octapeptide levels in rat brain are changed after subchronic neuroleptic treatment

1983 • 77 citations

Behavioural dissociation of the enkephalinergic systems of nucleus accumbens and nucleus caudatus

1977 • 71 citations

Conditioned place preference: An evaluation of morphine's positive reinforcing properties

1984 • 70 citations

The Brain Stem

1996 • 69 citations

Symposium on: Receptors of dopamine antagonists: New biochemical approaches

1978 • 60 citations

Opiate receptor binding in rhesus monkey brain: association with limbic structures

1978 • 57 citations

Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin

1985 • 54 citations

The Psychodynamics of Opiate Addiction

1984 • 51 citations

Effects of naloxone and its quaternary analogue on fluid consumption in water-deprived rats

1983 • 43 citations

Dopamine receptor changes after long-term haloperidol treatment in rats

1979 • 40 citations

Dopamine and methionine-enkephalin in human brain

1982 • 28 citations

Effects of haloperidol and sulpiride on dopamine-induced inhibition of nucleus accumbens neurons

1983 • 16 citations

Mesencephalic dopamine modulation of pituitary and central β-endorphin: Relation to food intake regulation

1983 • 12 citations

Evidence for interactions of endogenous peptides with the mesolimbic dopamine system.

1984 • 8 citations