Neurobiology of opiate abuse

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.

1984 • 1,060 citations

Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain

1988 • 980 citations

Self-administration of psychoactive substances by the monkey

1969 • 807 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Dynamics of Drug Dependence

1973 • 608 citations

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

1991 • 576 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning

1985 • 516 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

Opioid receptor-coupled second messenger systems

1991 • 466 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate

1974 • 373 citations

Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons

1990 • 341 citations

Reinforcing effects of morphine microinjection into the ventral tegmental area

1980 • 334 citations

Enkephalin blocks inhibitory pathways in the vertebrate CNS

1980 • 334 citations

Heroin reward is dependent on a dopaminergic substrate

1981 • 333 citations

Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system

1983 • 309 citations

Drug receptors and the inhibition of nerve cells

1989 • 308 citations

κ and δ-opioid receptor agonists differentially inhibit striatal dopamine and acetylcholine release

1984 • 275 citations

Molecular Characterization of Opioid Receptors

1990 • 266 citations

Drug reinstatement of heroin-reinforced responding in the rat

1983 • 266 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

Reinforcing effects of morphine in the nucleus accumbens

1982 • 254 citations

Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects

1990 • 251 citations

Pertussis toxin blocks the outward currents evoked by opiate and α2-agonists in locus coeruleus neurons

1986 • 241 citations

Self-administration of methionine enkephalin into the nucleus accumbens

1984 • 238 citations

Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area

1984 • 219 citations

Regulation of G proteins by chronic morphine in the rat locus coeruleus

1989 • 209 citations

Place preference conditioning reveals the involvement of D1-dopamine receptors in the motivational properties of μ- and κ-opioid agonists

1987 • 189 citations

Sensitization to repeated morphine injection in the rat: possible involvement of A10 dopamine neurons.

1987 • 176 citations

Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

1987 • 169 citations

Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats

1991 • 155 citations

Opioids activate both an inward rectifier and a novel voltage-gated potassium conductance in the hippocampal formation

1991 • 145 citations

Opioids and rewarding brain stimulation

1978 • 139 citations

Role of repeated exposure to morphine in determining its affective properties: place and taste conditioning studies in rats

1991 • 129 citations

Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens

1980 • 129 citations

Facilitation of self-stimulation behavior following intracerebral microinjections of opioids into the ventral tegmental area

1979 • 120 citations

Pharmacological regulation of intravenous cocaine and heroin self-administration in rats: A variable dose paradigm

1989 • 115 citations

Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat

1987 • 108 citations

Environment-specific cross-sensitization between the locomotor activating effects of morphine and amphetamine

1989 • 95 citations

Long-term sensitization to the excitatory effects of morphine

1983 • 92 citations

Conditioned increases in locomotor activity produced with morphine as an unconditioned stimulus, and the relation of conditioning to acute morphine effect and tolerance.

1981 • 91 citations

Modulation of transmitter and hormone release by multiple neuronal opioid receptors

2005 • 89 citations

Effects of 6-OHDA lesions of the central medial nucleus accumbens on rat intravenous morphine self-administration

1985 • 86 citations

Changes in response rates and reinforcement thresholds for intracranial self-stimulation during morphine withdrawal

1986 • 72 citations

Evidence That Receptor‐Linked G Protein Inhibits Exocytosis by a Post‐Second‐Messenger Mechanism in AtT‐20 Cells

1990 • 68 citations

Self-administration of small amounts of morphine through glass micropipettes into the ventral tegmental area of the rat

1989 • 67 citations

Effects of naloxone and pimozide on initiation and maintenance measures of free feeding

1986 • 66 citations

Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus

1990 • 56 citations

Potassium channels opened by noradrenaline and other transmitters in excised membrane patches of guinea‐pig submucosal neurones.

1992 • 56 citations

6-OHDA lesions of the ventral tegmental area block morphine-induced but not amphetamine-induced facilitation of self-stimulation

1985 • 51 citations

Opiate antagonists and self-stimulation: extinction-like response patterns suggest selective reward deficit

1989 • 29 citations

Noradrenaline, somatostatin and opioids inhibit activity of single HVA/N-type calcium channels in excised neuronal membranes

1991 • 27 citations

Pavlovian conditioning and addictive behavior: Relapse to oral self-administration of morphine.

1986 • 26 citations

Morphine-induced place conditioning is not confounded by drug-induced alterations in locomotor activity

1989 • 25 citations

Identification of MARPP(14–20), morphine- and cyclic AMP-regulated phosphoproteins of 14–20 kDa, as myelin basic proteins: evidence for their acute and chronic regulation by morphine in rat brain

1990 • 19 citations