SCH 23390 blocks drug-conditioned place-preference and place-aversion: anhedonia (lack of reward) or apathy (lack of motivation) after dopamine-receptor blockade?

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

The Pharmacological Basis for Therapeutics

1981 • 1,896 citations

Neuroleptics and operant behavior: The anhedonia hypothesis

1982 • 1,021 citations

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

1988 • 913 citations

SCH 23390, a potential benzazepine antipsychotic with unique interactions on dopaminergic systems.

1983 • 886 citations

Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol.

1986 • 852 citations

SCH 23390—The first selective dopamine D-1 antagonist

1983 • 738 citations

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

1986 • 693 citations

Drug reinforcement studied by the use of place conditioning in rat

1982 • 482 citations

Dopaminergic substrates of amphetamine-induced place preference conditioning

1982 • 381 citations

Heroin reward is dependent on a dopaminergic substrate

1981 • 333 citations

Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system

1983 • 309 citations

Reinforcing properties of morphine and naloxone revealed by conditioned place preferences: a procedural examination

1984 • 307 citations

The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat

1987 • 281 citations

Cocaine-induced place preference conditioning: Lack of effects of neuroleptics and 6-hydroxydopamine lesions

1982 • 241 citations

Location preference and flavor aversion reinforced by amphetamine in rats

1977 • 206 citations

Behavioral Pharmacology

1961 • 202 citations

Pharmacologic characterization of nicotine-induced conditioned place preference

1985 • 191 citations

Affective states associated with morphine injections

1976 • 184 citations

Neuroleptics block the positive reinforcing effects of amphetamine but not of morphine as measured by place conditioning

1985 • 180 citations

Preferential Stimulation of Dopamine Release in the Nucleus Accumbens by Opiates, Alcohol, and Barbiturates: Studies with Transcerebral Dialysis in Freely Moving Rats

1986 • 176 citations

Discriminating between reward and performance: A critical review of intracranial self-stimulation methodology

1983 • 174 citations

Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning

1987 • 169 citations

Rewarding and aversive effects of morphine: Temporal and pharmacological properties

1980 • 119 citations

Diazepam-induced place preference conditioning: Appetitive and antiaversive properties

1985 • 118 citations

Conditioned place preference with morphine: The effect of extinction training on the reinforcing CR

1984 • 108 citations

A rapid and inexpensive technique for assessing the reinforcing effects of opiate drugs

1979 • 108 citations

Effects of extinction, pimozide, SCH 23390, and metoclopramide on food-rewarded operant responding of rats

1987 • 94 citations

Repeated testing attenuates conditioned place preference with cocaine

1986 • 86 citations

Place conditioning with morphine and phencyclidine: Dose dependent effects

1985 • 84 citations

Apparent absence of nicotine-induced conditioned place preference in rats

1987 • 83 citations

Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

1986 • 80 citations

Spatial Avoidance in the Rat as a Result of Exposure to Ionizing Radiation

1957 • 76 citations

Conditioned place preference: An evaluation of morphine's positive reinforcing properties

1984 • 70 citations

Place preference conditioning with methylphenidate and nomifensine

1985 • 67 citations

Effects of Neuroleptics, Ethanol, Hypnotic-Sedatives, Tranquilizers, Narcotics, and Minor Stimulants in Aversive Paradigms

1978 • 56 citations

The actions of SCH 23390, a D1 receptor antagonist, on operant and avoidance behavior in rats

1987 • 43 citations

Neurotransmitter interactions in the basal ganglia

1988 • 41 citations

Place-aversion conditioned by phencyclidine in rats: development of tolerance and pharmacologic antagonism.

1985 • 20 citations

How do tranquilizing agents selectively inhibit conditioned avoidance responding?

1984 • 10 citations

Deleted Work

1955 • 0 citations