New concepts in cocaine addiction: The dopamine depletion hypothesis

Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

1954 • 3,047 citations

Problems of Drug Dependence

1969 • 970 citations

Self-administration of psychoactive substances by the monkey

1969 • 807 citations

Behavioral Medicine: Changing- Health Lifestyles

1980 • 803 citations

Catecholamine theories of reward: A critical review

1978 • 766 citations

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

1977 • 733 citations

Catecholamines: Basic and Clinical Frontiers

1979 • 730 citations

Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

1977 • 716 citations

Increased Lever Pressing for Amphetamine After Pimozide in Rats: Implications for a Dopamine Theory of Reward

1975 • 536 citations

Cortical Dopaminergic Involvement in Cocaine Reinforcement

1983 • 491 citations

Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

1977 • 490 citations

Reinforcement and Behavior

1969 • 469 citations

Frontiers in Neuroendocrinology

1975 • 431 citations

Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain

1971 • 405 citations

Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue

1969 • 321 citations

Cocaine Abuse Treatment

1984 • 298 citations

Pleasure Centers in the Brain

1956 • 280 citations

Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and ?relapse? in morphine-addicted rats

1967 • 273 citations

Effect of Cocaine on the Disposition of Noradrenaline labelled with Tritium

1960 • 237 citations

ANALYSIS OF THE MG++-ATP DEPENDENT STORAGE MECHANISM IN THE AMINE GRANULES OF THE ADRENAL MEDULLA.

1963 • 230 citations

DOPAMINE INFUSION ACUTELY INHIBITS THE TSH AND PROLACTIN RESPONSE TO TRH

1975 • 200 citations

Effect of 5-Hydroxytryptophan on Serum Cortisol Levels in Major Affective Disorders

1984 • 197 citations

The effects of chlorpromazine on psychomotor stimulant self-administration in the Rhesus monkey

1972 • 186 citations

Amphetamine-type reinforcement by dopaminergic agonists in the rat

1978 • 182 citations

Adherence, Compliance and Generalization in Behavioral Medicine

1982 • 176 citations

The Antagonism of Amphetamine-Induced Symptomatology by a Neuroleptic

1974 • 149 citations

Clinical trials with amphetamine-blocking drugs.

1972 • 147 citations

Self regulation of membrane receptors

1976 • 144 citations

Role of noradrenergic and dopaminergic processes in amphetamine self-administration

1976 • 144 citations

Discriminative stimulus properties of cocaine: Neuropharmacological characteristics as derived from stimulus generalization experiments

1979 • 141 citations

Thyrotropin-Releasing Hormone (TRH): Neurotransmitter Regulation of Secretion by Mouse Hypothalamic TissueIn Vitro

1973 • 140 citations

Trends in the epidemiology of alcoholism

1978 • 133 citations

Comparison of inhibition of monoamine uptake by cocaine, methylphenidate and amphetamine.

1978 • 131 citations

Significance of dopamine metabolites in the evaluation of drugs acting on dopaminergic neurones

1978 • 126 citations

Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: relationship to kindling and psychosis.

1976 • 121 citations

Adrenergic Blockade and the Corticosteroid and Growth Hormone Responses to Methylamphetamine

1970 • 111 citations

Augmentation of Thyrotropin Responses to Thyrotropin-Releasing Hormone Following Small Decreases in Serum Thyroid Hormone Concentrations

1975 • 109 citations

Neurochemical effects of cocaine following acute and repeated injection

1977 • 107 citations

Chronic Cocaine Abuse: Evidence for Adverse Effects on Health and Functioning

1984 • 106 citations

Narcotic Drugs: Effects on the Serotonin Biosynthetic Systems of the Brain

1972 • 105 citations

Blockade of serotonin receptors on autonomic neurones by (−)-cocaine and some related compounds

1979 • 103 citations

Dextroamphetamine and Cortisol in Depression

1980 • 100 citations

Influence of amphetamines on plasma corticosteroid and growth hormone levels in man

1969 • 99 citations

The role of dopamine in the discriminative stimulus properties of cocaine

1980 • 99 citations

Uptake of Some Tritiated Sympathomimetic Amines by Mouse Brain Cortex Slices In Vitro

1966 • 97 citations

Naltrexone, opiate addiction, and endorphins

1982 • 90 citations

Corticosteroid and growth hormone responses to methylamphetamine in depressive illness

1979 • 86 citations

Effect of quipazine on rat plasma prolactin levels

1976 • 83 citations

Cocaine abuse: neurochemistry, phenomenology, and treatment.

1985 • 81 citations

EFFECTS OF ACUTE COCAINE TREATMENT ON THE TURNOVER OF 5‐HYDROXYTRYPTAMINE IN THE RAT BRAIN

1975 • 73 citations

Cocaine-induced supersensitivity of striatal dopamine receptors: role of endogenous calmodulin

1981 • 68 citations

Correlation of behavioral and neurochemical effects of acute administration of cocaine in rats

1978 • 65 citations

Chemistry of Purposive Behavior

1969 • 65 citations

Increased dopamine receptor binding in rat brain by repeated cocaine injections.

1979 • 65 citations

Amphetamine-Induced Hyperthyroxinemia

1980 • 51 citations

Blocking effect of α-methyltyrosine on amphetamine based reinforcement

1973 • 49 citations

New insights and treatments: opiate withdrawal and cocaine addiction.

1984 • 47 citations

A study of the role of catecholamines in the response to various central stimulants

1973 • 46 citations

Regulation of the Hypophysiotropic Secretions of the Brain

1975 • 40 citations

Effect of 5,7-dihydroxytryptamine on serotonergic control of prolactin secretion and behavior in rats

1981 • 38 citations

Alpha-methyltyrosine to prevent self-administration of morphine and amphetamine.

1972 • 37 citations

Cocaine and amphetamine dependence treated with desipramine.

1983 • 36 citations

Double-blind comparison of desipramine and placebo in withdrawal from cocaine dependence.

1984 • 33 citations

A NEW ANIMAL MODEL FOR SCHIZOPHRENIA: BEHAVIORAL AND RECEPTOR BINDING STUDIES

1979 • 31 citations

Antagonism of cocaine highs by lithium

1978 • 30 citations

Effects of cocaine and amphetamine on the metabolism of tryptophan and 5-hydroxytryptamine in mouse brain in vivo

1970 • 29 citations

Antagonism of Cocaine Highs by Lithium

1981 • 29 citations

Behavioral Effects of Cocaine in Animals

1977 • 27 citations

What are the Effects of Cocaine in Man?

1977 • 26 citations

Apomorphine self-injection is not affected by alpha-methylparatyrosine treatment: Support for dopaminergic reward

1976 • 25 citations

Accumulation of α-methyltyramine by the noradrenaline uptake process in the isolated rat heart

1966 • 22 citations

Potentiation by cocaine of the stimulus-induced increase in dopamine synthesis in rat brain striatal synaptosomes

1977 • 21 citations

Chlorpromazine-cocaine antagonism: Its relation to changes of dopamine metabolism in the brain

1971 • 21 citations

Neurotransmitter and neuroendocrine abnormalities associated with cocaine use.

1985 • 19 citations

Platelet serotonin transporter in cocaine patients.

1984 • 18 citations

Endorphins, lithium, and naloxone: their relationship to pathological and drug-induced manic-euphoric states.

1978 • 15 citations

Cocaine Smoking

1979 • 13 citations

Supersensitivity to catecholamines after impairment of extraneuronal uptake or catechol-O-methyl transferase.

1975 • 12 citations

Regulation of the hypophysiotropic secretions of the brain

1975 • 11 citations

Chronic administration of cocaine: Effects on defaecation and adrenal hypertrophy in the rat

1973 • 10 citations

The prolactin response to intravenous dextroamphetamine in normal young men and postmenopausal women

1981 • 9 citations

Activity of amphetamine in hypothyroid rats

1968 • 9 citations

National Household Survey on Drug Abuse, 1991

1993 • 6 citations