Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

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1969 • 1,466 citations

The opponent-process theory of acquired motivation: The costs of pleasure and the benefits of pain.

1980 • 932 citations

The opponent-process theory of acquired motivation: The costs of pleasure and the benefits of pain.

1980 • 853 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1981 • 850 citations

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

1980 • 736 citations

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

1977 • 733 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

1982 • 560 citations

Destruction of dopaminergic nerve terminals in nucleus accumbens: Effect on d-amphetamine self-administration

1979 • 460 citations

Anatomically Distinct Opiate Receptor Fields Mediate Reward and Physical Dependence

1984 • 265 citations

Drug dependence: its significance and characteristics.

1966 • 264 citations

Quantitative aspects of precipitated abstinence in morphine-dependent rats.

1973 • 252 citations

The neuropharmacological basis of reward

1991 • 249 citations

Self-administration of methionine enkephalin into the nucleus accumbens

1984 • 238 citations

Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens

1985 • 232 citations

Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat

1985 • 175 citations

A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats.

1977 • 148 citations

Rewarding properties of β-endorphin as measured by conditioned place preference

1987 • 123 citations

Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.

1984 • 117 citations

Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats

1988 • 117 citations

Substantia innominata: Critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat

1984 • 115 citations

Brain sites of precipitated abstinence in morphine-dependent rats.

1973 • 108 citations

Morphine withdrawal syndrome: Differential participation of structures located within the amygdaloid complex and striatum of the rat

1979 • 94 citations

Neuroanatomical Correlates of Morphine Dependence

1972 • 94 citations

The neural substrates of apomorphine-stimulated locomotor activity following denervation of the nucleus accumbens

1984 • 92 citations

Ventral tegmental site of opiate reward: Antagonism by a hydrophilic opiate receptor blocker

1983 • 91 citations

Effects of 6-OHDA lesions of the central medial nucleus accumbens on rat intravenous morphine self-administration

1985 • 86 citations

Low doses of methylnaloxonium in the nucleus accumbens antagonize hyperactivity induced by heroin in the rat

1985 • 78 citations

Lack of an effect of 6-hydroxydopamine lesions of the nucleus accumbens on intravenous morphine self-administration

1988 • 78 citations

Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites

1980 • 71 citations

Brain neurotransmitter turnover correlated with morphine-seeking behavior of rats

1982 • 69 citations

Kainic acid lesions of the nucleus accumbens selectively attenuate morphine self-administration

1988 • 64 citations

Antagonist treatment in nucleus accumbers or periaqueductal grey affects heroin self-administration

1988 • 60 citations

Neurotransmitter turnover in rat striatum is correlated with morphine self-administration

1980 • 54 citations

Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the rat

1985 • 42 citations

Morphine abstinence syndrome in rabbits precipitated by injection of morphine antagonists into the ventricular system and restricted parts of it

1972 • 40 citations

Effects of morphine withdrawal on food competition hierarchies and fighting behavior in rats

1979 • 17 citations

An animal model for opiate induced euphoria and analgesia.

1982 • 2 citations