Linking oxidative stress to inflammation: Toll-like receptors

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

Heart-Lung Transplantation

2016 • 2,165 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

2004 • 1,533 citations

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

2005 • 1,360 citations

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

2007 • 1,306 citations

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

2008 • 1,280 citations

Innate immunity: an overview

2003 • 1,227 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran

2007 • 1,082 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

2002 • 949 citations

TLR4 activation mediates kidney ischemia/reperfusion injury

2007 • 796 citations

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

2007 • 734 citations

CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses

2009 • 701 citations

IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

2002 • 676 citations

Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function

2006 • 667 citations

Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium

1999 • 639 citations

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

2004 • 609 citations

Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice

2004 • 603 citations

HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling

2007 • 589 citations

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

2008 • 572 citations

Toll-Like Receptor 4 Is Involved in Brain Damage and Inflammation After Experimental Stroke

2007 • 569 citations

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

2003 • 548 citations

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

2005 • 544 citations

Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-κB

2004 • 527 citations

Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway

2004 • 442 citations

In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation

2002 • 431 citations

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

2008 • 426 citations

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

2008 • 384 citations

Inflammatory Response After Open Heart Surgery

2002 • 362 citations

Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells

2005 • 356 citations

Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-κB dependent inflammatory response☆

2006 • 352 citations

Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction

2003 • 290 citations

Inhibition of Toll-like Receptor 4 With Eritoran Attenuates Myocardial Ischemia-Reperfusion Injury

2006 • 274 citations

Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH

2000 • 271 citations

TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways

2007 • 267 citations

S100A8 and S100A9 Mediate Endotoxin-Induced Cardiomyocyte Dysfunction via the Receptor for Advanced Glycation End Products

2008 • 266 citations

Ischemia-Reperfusion Injury: Processes in Pathogenetic Networks: A Review

2007 • 265 citations

Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors

2003 • 256 citations

Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia

2007 • 248 citations

The non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-κB-inducing kinase pathways: Role of H2O2 in NF-κB activation

2008 • 243 citations

The intracellular distribution and function of the high mobility group chromosomal proteins

1985 • 241 citations

Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice

2006 • 239 citations

TLR2 has a detrimental role in mouse transient focal cerebral ischemia

2007 • 237 citations

Oxidants and Antioxidants in Viral Diseases: Disease Mechanisms and Metabolic Regulation

1997 • 234 citations

Cutting Edge: An Endogenous Pathway to Systemic Inflammatory Response Syndrome (SIRS)-Like Reactions through Toll-Like Receptor 4

2004 • 232 citations

Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart

2008 • 230 citations

Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

2008 • 227 citations

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

2000 • 227 citations

Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver

2006 • 225 citations

Post-translational Methylation of High Mobility Group Box 1 (HMGB1) Causes Its Cytoplasmic Localization in Neutrophils

2007 • 222 citations

Systemic inflammation and remote organ injury following trauma require HMGB1

2007 • 221 citations

Anti-HMGB1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival after Hemorrhagic Shock

2006 • 219 citations

Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart

2004 • 218 citations

IRAK-4 as the central TIR signaling mediator in innate immunity

2002 • 211 citations

The Strength of Receptor Signaling Is Centrally Controlled through a Cooperative Loop between Ca2+ and an Oxidant Signal

2005 • 204 citations

Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion

2007 • 197 citations

Hemorrhagic Shock Primes for Increased Expression of Cytokine-Induced Neutrophil Chemoattractant in the Lung: Role in Pulmonary Inflammation Following Lipopolysaccharide

1998 • 196 citations

Reactive oxygen species: toxic molecules or spark of life?

2006 • 194 citations

Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages

2006 • 188 citations

Ischemia-Reperfusion Injury Activates Innate Immunity in Rat Kidneys

2005 • 185 citations

Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia

2007 • 183 citations

Alarmins Initiate Host Defense

2007 • 182 citations

Toll‐Like Receptor and Heme Oxygenase‐1 Signaling in Hepatic Ischemia/Reperfusion Injury

2005 • 173 citations

Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin

2007 • 172 citations

Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism

2008 • 161 citations

Toll-Like Receptors 2-Deficient Mice Are Protected Against Postischemic Coronary Endothelial Dysfunction

2007 • 160 citations

N‐acetylcysteine reduces lipopolysaccharide‐sensitized hypoxic‐ischemic brain injury

2007 • 154 citations

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

2008 • 154 citations

Changes in hyaluronan production and metabolism following ischaemic stroke in man

2006 • 138 citations

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

2009 • 135 citations

Hemorrhage-induced acute lung injury is TLR-4 dependent

2004 • 132 citations

Toll Receptor-Mediated Regulation of NADPH Oxidase in Human Dendritic Cells

2004 • 126 citations

Cutting Edge: TLR4 Deficiency Confers Susceptibility to Lethal Oxidant Lung Injury

2005 • 124 citations

Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase.

1983 • 120 citations

Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury

2006 • 118 citations

Nitric Oxide-Induced Nitrative Stress Involved in Microbial Pathogenesis

2005 • 117 citations

Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury

2006 • 114 citations

Toll-Like Receptor-4 Signaling Mediates Hepatic Injury and Systemic Inflammation in Hemorrhagic Shock

2006 • 113 citations

Toll-Like Receptor 4 Mediates Lung Ischemia-Reperfusion Injury

2006 • 109 citations

Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model

2007 • 105 citations

Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart

2009 • 104 citations

Both Hemopoietic and Resident Cells Are Required for MyD88-Dependent Pulmonary Inflammatory Response to Inhaled Endotoxin

2005 • 101 citations

Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction

2006 • 100 citations

Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4

2006 • 100 citations

Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice.

2004 • 97 citations

TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF

2005 • 94 citations

Protective Mechanism of Epigallocatechin‐3‐Gallate against Helicobacter pylori‐Induced Gastric Epithelial Cytotoxicity via the Blockage of TLR‐4 Signaling

2004 • 94 citations

Type I, but not type II, interferon is critical in liver injury induced after ischemia and reperfusion

2007 • 94 citations

Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation

2005 • 83 citations

Overexpression of Human S100B Exacerbates Brain Damage and Periinfarct Gliosis After Permanent Focal Ischemia

2008 • 82 citations

Candida albicans Induces Selectively Transcriptional Activation of Cyclooxygenase-2 in HeLa Cells: Pivotal Roles of Toll-Like Receptors, p38 Mitogen-Activated Protein Kinase, and NF-κB

2003 • 82 citations

Cerebral Inflammatory Response After Fetal Asphyxia and Hyperoxic Resuscitation in Newborn Sheep

2007 • 78 citations

Toll-Like Receptor 4 Mediates the Early Inflammatory Response After Cold Ischemia/Reperfusion

2007 • 78 citations

Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells

2007 • 75 citations

Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function

2007 • 75 citations

Activation of the lipopolysaccharide signaling pathway in hepatic transplantation preservation injury12

2002 • 72 citations

Heme Oxygenase-1 Mediated Cytoprotection Against Liver Ischemia and Reperfusion Injury: Inhibition of Type-1 Interferon Signaling

2007 • 72 citations

Evidence for the Pivotal Role of Endogenous Toll-Like Receptor 4 Ligands in Liver Ischemia and Reperfusion Injury

2008 • 71 citations

The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury

2006 • 69 citations

Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection

2004 • 62 citations

Toll-like Receptor and Cytokine Gene Expression in the Early Phase of Human Lung Transplantation

2006 • 57 citations

TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage

2007 • 57 citations

Activation of hepatocytes by extracellular heat shock protein 72

2008 • 56 citations

Ischemia-Induced Exocytosis of Weibel-Palade Bodies Mobilizes Stem Cells

2008 • 55 citations

Toll-like receptor 2 is protective of ischemia–reperfusion-mediated small-bowel injury in a murine model

2008 • 55 citations

CD14 but not MD2 transmit signals from DAMP

2009 • 51 citations

Interacting Neuroendocrine and Innate and Acquired Immune Pathways Regulate Neutrophil Mobilization from Bone Marrow following Hemorrhagic Shock

2009 • 48 citations

TLR LIGAND DECREASES MESENTERIC ISCHEMIA AND REPERFUSION INJURY-INDUCED GUT DAMAGE THROUGH TNF-α SIGNALING

2008 • 46 citations

The Role of Toll-Like Receptors 2 and 4 in Acute Allograft Rejection After Liver Transplantation

2007 • 46 citations

Effect of hemorrhagic shock on gut barrier function and expression of stress-related genes in normal and gnotobiotic mice

2002 • 45 citations

Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-α receptor

2004 • 43 citations

HEMORRHAGIC SHOCK IN ENDCTOXIN RESISTANT MICE

1992 • 32 citations

Differential effect of resuscitation on Toll-like receptors in a model of hemorrhagic shock without a septic challenge

2007 • 29 citations

TOLL-LIKE RECEPTOR 4 REGULATES HEME OXYGENASE-1 EXPRESSION AFTER HEMORRHAGIC SHOCK INDUCED ACUTE LUNG INJURY IN MICE

2009 • 28 citations

Exposure to Bacterial DNA Before Hemorrhagic Shock Strongly Aggravates Systemic Inflammation and Gut Barrier Loss via an IFN-γ-Dependent Route

2007 • 24 citations

POSTISCHEMIC VASCULAR PERMEABILITY REQUIRES BOTH TLR-2 AND TLR-4, BUT ONLY TLR-2 MEDIATES THE TRANSENDOTHELIAL MIGRATION OF LEUKOCYTES

2009 • 24 citations

The impact of free radical-mediated reperfusion injury on acute and chronic rejection events following cadaveric renal transplantation.

1993 • 24 citations

Recruitment of the Interleukin-1 Receptor (IL-1RI)-Associated Kinase IRAK to the IL-1RI Is Redox Regulated

2003 • 21 citations

Toll-Like Receptor 2 and 4 Expression After Severe Injury is Not Involved in the Dysregulation of the Innate Immune System

2007 • 18 citations

Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts

2005 • 13 citations

Decreased Lactate in Endotoxin-Resistant Mice Undergoing Hemorrhage Is Independent of Tumor Necrosis Factor Availability

1994 • 5 citations

[Expression of Toll-like receptor 2/4 mRNA in myocardium in mice with hemorrhagic shock].

2006 • 2 citations