Alarmins Initiate Host Defense

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

DAMPs, PAMPs and alarmins: all we need to know about danger

2006 • 2,668 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

2000 • 1,219 citations

Innate antimicrobial peptide protects the skin from invasive bacterial infection

2001 • 1,206 citations

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

1995 • 1,116 citations

High mobility group box 1 protein interacts with multiple Toll-like receptors

2005 • 905 citations

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

2002 • 885 citations

Alarmins: chemotactic activators of immune responses

2005 • 759 citations

HMGB1 is an endogenous immune adjuvant released by necrotic cells

2004 • 576 citations

Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense

2004 • 557 citations

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

1996 • 551 citations

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

2000 • 489 citations

RAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages

2005 • 485 citations

Defensins in innate antiviral immunity

2006 • 471 citations

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

2001 • 465 citations

Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3

2003 • 418 citations

Cathelicidins - a family of multifunctional antimicrobial peptides

2003 • 409 citations

Identification of a novel, multifunctional *-defensin (human *-defensin 3) with specific antimicrobial activity

2001 • 407 citations

High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin

2006 • 373 citations

Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2–MyD88 signal pathway in dendritic cells and enhances Th2 immune responses

2008 • 342 citations

T cell costimulation by chemokine receptors

2005 • 336 citations

Mechanisms for induction of acquired host immunity by neutrophil peptide defensins

1999 • 301 citations

Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens

2001 • 280 citations

CCL19 and CCL21 Induce a Potent Proinflammatory Differentiation Program in Licensed Dendritic Cells

2005 • 262 citations

Regulation of monocyte migration by amphoterin (HMGB1)

2004 • 249 citations

Human α-defensins block papillomavirus infection

2006 • 228 citations

Interplay between antibacterial effectors: A macrophage antimicrobial peptide impairs intracellular Salmonella replication

2004 • 225 citations

Mouse Cathelin-Related Antimicrobial Peptide Chemoattracts Leukocytes Using Formyl Peptide Receptor-Like 1/Mouse Formyl Peptide Receptor-Like 2 as the Receptor and Acts as an Immune Adjuvant

2005 • 219 citations

β-Defensin 1 Contributes to Pulmonary Innate Immunity in Mice

2002 • 216 citations

Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells

2003 • 150 citations

Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin–sensitive P2y receptors

2002 • 148 citations

Human Ribonuclease A Superfamily Members, Eosinophil-Derived Neurotoxin and Pancreatic Ribonuclease, Induce Dendritic Cell Maturation and Activation

2004 • 142 citations

The impact of endogenous triggers on trauma-associated inflammation

2006 • 123 citations

Granulysin, a Cytolytic Molecule, Is Also a Chemoattractant and Proinflammatory Activator

2005 • 112 citations

Ribonuclease is partly responsible for the HIV-1 inhibitory effect activated by HLA alloantigen recognition

2003 • 94 citations

Immunostimulatory combinations: designing the next generation of vaccine adjuvants

2006 • 79 citations

Prevalence and characterization of novel pANCA, antibodies to the high mobility group non-histone chromosomal proteins HMG1 and HMG2, in systemic rheumatic diseases.

1998 • 73 citations

A New Look at Crohn's Disease

2006 • 63 citations

Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class II processing pathway in vitro and induces protective immunity in vivo

2004 • 54 citations

Vaccine with β-Defensin 2–Transduced Leukemic Cells Activates Innate and Adaptive Immunity to Elicit Potent Antileukemia Responses

2006 • 33 citations

Cancer immunotherapy and heat-shock proteins: promises and challenges

2004 • 25 citations

Deleted Work

1955 • 0 citations