Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

2000 • 772 citations

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Oxidative Stress and Cell Signalling

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Evolving Concepts in the Pathogenesis of Postinjury Multiple Organ Failure

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Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

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Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction

2002 • 452 citations

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

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Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB

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Lipid Rafts and the Regulation of Exocytosis

2004 • 291 citations

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

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Hemorrhagic Shock Primes for Increased Expression of Cytokine-Induced Neutrophil Chemoattractant in the Lung: Role in Pulmonary Inflammation Following Lipopolysaccharide

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Jasplakinolide: An Actin-Specific Reagent that Promotes Actin Polymerization

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Lipid rafts make for slippery platforms

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Early Risk Factors for Postinjury Multiple Organ Failure

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Heat-shock protein 70 and heat-shock protein 90 associate with Toll-like receptor 4 in response to bacterial lipopolysaccharide

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Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses

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Manipulation of Cholesterol Levels in Rod Disk Membranes by Methyl-β-cyclodextrin

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Regulation of Toll-Like Receptor 4 Expression in the Lung Following Hemorrhagic Shock and Lipopolysaccharide

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Toll‐like receptor 4 expression levels determine the degree of LPS‐susceptibility in mice

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Signaling through sphingolipid microdomains of the plasma membrane: the concept of signaling platform.

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Overexpression of Toll-Like Receptor 4 Amplifies the Host Response to Lipopolysaccharide and Provides a Survival Advantage in Transgenic Mice

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Twenty-five percent albumin prevents lung injury following shock/resuscitation

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Hypertonic Immunomodulation Is Reversible and Accompanied by Changes in CD11b Expression

1999 • 75 citations

Priming for Enhanced Alveolar Fibrin Deposition after Hemorrhagic Shock

2000 • 68 citations

Oxidative Stress Reprograms Lipopolysaccharide Signaling via Src Kinase-dependent Pathway in RAW 264.7 Macrophage Cell Line

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Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses

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The role of the Src family of tyrosine kinases after oxidant-induced lung injury in vivo

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Jasplakinolide: An Actin-Specific Reagent that Promotes Actin Polymerization

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Cell Distributions and Functions of Toll-like Receptor 4 Studied by Fluorescent Gene Constructs

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Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway

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Glutathione depletion inhibits lipopolysaccharide-induced intercellular adhesion molecule 1 synthesis

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