Hemorrhage-induced acute lung injury is TLR-4 dependent

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1998 • 7,541 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

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2000 • 4,409 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

1999 • 1,570 citations

MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways

1998 • 1,565 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4

2001 • 947 citations

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 • 803 citations

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

2000 • 789 citations

MyD88, an Adapter Protein Involved in Interleukin-1 Signaling

1998 • 634 citations

The smallest known non-avian theropod dinosaur

2000 • 530 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury

2000 • 401 citations

Endotoxin Contamination in Recombinant Human Heat Shock Protein 70 (Hsp70) Preparation Is Responsible for the Induction of Tumor Necrosis Factor α Release by Murine Macrophages

2002 • 399 citations

Hemorrhagic Shock Induces Bacterial Translocation from the Gut

1988 • 390 citations

Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome

1996 • 288 citations

Evans blue dye as a marker of albumin clearance in cultured endothelial monolayer and isolated lung

1992 • 234 citations

Cutting Edge: An Endogenous Pathway to Systemic Inflammatory Response Syndrome (SIRS)-Like Reactions through Toll-Like Receptor 4

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1994 • 215 citations

Hemorrhagic shock-induced bacterial translocation is reduced by xanthine oxidase inhibition or inactivation.

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Thirty years of clinical trials in acute respiratory distress syndrome

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Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin

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1999 • 148 citations

Activation of Mammalian Toll-like Receptors by Endogenous Agonists

2003 • 147 citations

Regulation of Toll-Like Receptor 4 Expression in the Lung Following Hemorrhagic Shock and Lipopolysaccharide

2002 • 112 citations

Control of repetitive electrical discharges by means of an external electrode

1992 • 111 citations

Hemorrhage and resuscitation induce alterations in cytokine expression and the development of acute lung injury.

1994 • 102 citations

Attenuation of lung reperfusion injury after transplantation using an inhibitor of nuclear factor-κB

2000 • 102 citations

Intratracheal administration of endotoxin and cytokines. VI. Antiserum to CINC inhibits acute inflammation

1995 • 91 citations

Pyrrolidine Dithiocarbamate Attenuates Endotoxin-induced Acute Lung Injury

1997 • 88 citations

Xanthine oxidase-derived oxygen radicals increase lung cytokine expression in mice subjected to hemorrhagic shock.

1995 • 87 citations

Comparison of plasma cytokine levels in rats subjected to superior mesenteric artery occlusion or hemorrhagic shock.

1995 • 87 citations

Hemorrhage induces rapid in vivo activation of CREB and NF-kappaB in murine intraparenchymal lung mononuclear cells.

1997 • 73 citations

Macrophages derived from C3H/HeJ (Lpsd) mice respond to bacterial lipopolysaccharide by activating NF-χB

1995 • 70 citations

Interactions between CBP, NF-κB, and CREB in the lungs after hemorrhage and endotoxemia

2001 • 69 citations

Hemorrhage activates NF-kappa B in murine lung mononuclear cells in vivo

1996 • 69 citations

A low level of TNF-α mediates hemorrhage-induced acute lung injury via p55 TNF receptor

2001 • 62 citations

Transcriptional Regulation of the Tumor Necrosis Factor α Gene

1995 • 61 citations

Activation of Extracellular Signal-Regulated Kinases, NF-κB, and Cyclic Adenosine 5′-Monophosphate Response Element-Binding Protein in Lung Neutrophils Occurs by Differing Mechanisms After Hemorrhage or Endotoxemia

2001 • 60 citations

Contribution of tumor necrosis factor-alpha to pulmonary cytokine expression and lung injury after hemorrhage and resuscitation

1995 • 54 citations

TNF Receptor I Mediates Chemokine Production and Neutrophil Accumulation in the Lung Following Systemic Lipopolysaccharide

2001 • 40 citations

Neutrophil depletion attenuates endotoxin-induced dysfunction of cGMP-mediated pulmonary vasorelaxation

1996 • 38 citations

Temporal sequence of pulmonary cytokine gene expression in response to endotoxin in C3H/HeN endotoxin-sensitive and C3H/HeJ endotoxin-resistant mice

1995 • 38 citations

Interleukin-11 attenuates pulmonary inflammation and vasomotor dysfunction in endotoxin-induced lung injury

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HEMORRHAGIC SHOCK IN ENDCTOXIN RESISTANT MICE

1992 • 32 citations

The Importance of Polymorphonuclear Leukocytes in Lipopolysaccharide-Induced Superoxide Anion Production and Lung Injury: Ex Vivo Observation in Rat Lungs

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Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia

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HEMORRHAGIC SHOCK IN ENDOTOXIN-RESISTANT MICE

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Toll-like Receptor-4 Signaling Mediates Pulmonary Neutrophil Sequestration in Response to Gram-Positive Bacterial Enterotoxin

2002 • 23 citations

THE INTESTINAL CYTOKINE RESPONSE AFTER GOT ISCHEMIA

1995 • 7 citations