Small cell lung cancer: from molecular biology to novel therapeutics

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Cancer Statistics, 2002

2002 • 2,954 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Twice-Daily Compared with Once-Daily Thoracic Radiotherapy in Limited Small-Cell Lung Cancer Treated Concurrently with Cisplatin and Etoposide

1999 • 1,394 citations

Irinotecan plus Cisplatin Compared with Etoposide plus Cisplatin for Extensive Small-Cell Lung Cancer

2002 • 1,346 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

A Meta-Analysis of Thoracic Radiotherapy for Small-Cell Lung Cancer

1992 • 1,295 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Redox Regulation of Cellular Signalling

1999 • 1,146 citations

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

2000 • 1,073 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Topotecan Versus Cyclophosphamide, Doxorubicin, and Vincristine for the Treatment of Recurrent Small-Cell Lung Cancer

1999 • 909 citations

Neuroendocrine Tumors of the Lung With Proposed Criteria for Large-Cell Neuroendocrine Carcinoma

1991 • 862 citations

Superoxide dismutase as a target for the selective killing of cancer cells

2000 • 824 citations

Does thoracic irradiation improve survival and local control in limited-stage small-cell carcinoma of the lung? A meta-analysis.

1992 • 802 citations

Epigenetic Inactivation of RASSF1A in Lung and Breast Cancers and Malignant Phenotype Suppression

2001 • 770 citations

Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group.

1993 • 716 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Phase III Study of Concurrent Versus Sequential Thoracic Radiotherapy in Combination With Cisplatin and Etoposide for Limited-Stage Small-Cell Lung Cancer: Results of the Japan Clinical Oncology Group Study 9104

2002 • 671 citations

Pathology of lung cancer

2002 • 650 citations

Regulators of cell death

1995 • 647 citations

Taxol binds to polymerized tubulin in vitro

1981 • 618 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

The biology of stem cell factor and its receptor C-kit

1999 • 564 citations

Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis

1999 • 558 citations

The FHIT Gene at 3p14.2 Is Abnormal in Lung Cancer

1996 • 547 citations

Phosphoinositide kinases

1996 • 529 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Prophylactic Cranial Irradiation for Patients With Small-Cell Lung Cancer in Complete Remission

1995 • 513 citations

The PI3K‒PDK1 connection: more than just a road to PKB

2000 • 503 citations

Chemotherapy with or without Radiation Therapy in Limited Small-Cell Carcinoma of the Lung

1987 • 484 citations

Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group.

1997 • 474 citations

Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer

1987 • 472 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer.

1992 • 443 citations

Role of oxidants/antioxidants in smoking-induced lung diseases

1996 • 414 citations

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

1987 • 396 citations

Early signaling pathways activated by c-Kit in hematopoietic cells

1999 • 385 citations

Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: Results of a multicentre randomised trial

1997 • 363 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Deletions of the Short Arm of Chromosome 3 in Solid Tumors and the Search for Suppressor Genes

1997 • 340 citations

Initial versus delayed accelerated hyperfractionated radiation therapy and concurrent chemotherapy in limited small-cell lung cancer: a randomized study.

1997 • 339 citations

A nonrandom chromosomal abnormality, del 3p(14–23), in human small cell lung cancer (SCLC)

1982 • 318 citations

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

1992 • 316 citations

Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling

1999 • 289 citations

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer.

1993 • 283 citations

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells.

2002 • 280 citations

Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor.

1996 • 275 citations

Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors.

1996 • 273 citations

The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth.

2000 • 271 citations

Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer.

1991 • 258 citations

Regulation of protein kinase C and role in cancer biology

1994 • 258 citations

Surgical resection in the management of small cell carcinoma of the lung

1982 • 255 citations

Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression.

1999 • 248 citations

Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.

2002 • 222 citations

Chromosomal imbalances in human lung cancer

2002 • 207 citations

Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: an Eastern Cooperative Oncology Group Trial.

1996 • 206 citations

Phase III Comparison of Twice-Daily Split-Course Irradiation Versus Once-Daily Irradiation for Patients With Limited Stage Small-Cell Lung Carcinoma

1999 • 203 citations

Three distinct regions involved in 3p deletion in human lung cancer

1993 • 200 citations

CLINICAL IMPLICATIONS OF THE p53 GENE

1996 • 200 citations

The potential of protein kinase C as A target for anticancer treatment

1993 • 200 citations

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

1998 • 198 citations

Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.

1996 • 193 citations

Preferential expression of c-kit protooncogene transcripts in small cell lung cancer

1992 • 182 citations

Phase II study of paclitaxel in patients with extensive-disease small-cell lung cancer: an Eastern Cooperative Oncology Group study.

1995 • 178 citations

The role of p53-target genes in human cancer

2000 • 176 citations

Randomized study of initial versus late chest irradiation combined with chemotherapy in limited-stage small-cell lung cancer. Aarhus Lung Cancer Group.

1997 • 174 citations

The p53 gene family

1999 • 174 citations

Phase II study of irinotecan combined with cisplatin in patients with previously untreated small-cell lung cancer. West Japan Lung Cancer Group.

1998 • 170 citations

Apoptosis of Lung Cancer Cells Caused by Some Anti-cancer Agents (MMC, CPT-11, ADM) is Inhibited by BCL-2

1993 • 168 citations

Expression of bcl‐2 oncogene protein is prevalent in small cell lung carcinomas

1995 • 167 citations

Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts

1993 • 164 citations

Expression and Prognostic Significance of Metalloproteinases and Their Tissue Inhibitors in Patients With Small-Cell Lung Cancer

1999 • 158 citations

Clinical biology of small cell carcinoma: relationship to surgical therapy.

1978 • 152 citations

HGF: a multifunctional growth factor controlling cell scattering

1999 • 147 citations

The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.

1998 • 145 citations

Gemcitabine is an active new agent in previously untreated extensive small cell lung cancer (SCLC)

1994 • 144 citations

Molecular and pathologic markers in stage I non-small-cell carcinoma of the lung.

1995 • 141 citations

Treatment of patients with small-cell lung cancer refractory to etoposide and cisplatin with the topoisomerase I poison topotecan.

1996 • 132 citations

Activity of docetaxel (Taxotere) in small cell lung cancer

1994 • 130 citations

Randomized comparison of early versus late hyperfractionated thoracic irradiation concurrently with chemotherapy in limited disease small-cell lung cancer: A randomized phase II study of the Hellenic Cooperative Oncology Group (HeCOG)

2001 • 125 citations

Thoracic radiation therapy added to chemotherapy for small-cell lung cancer: an update of Cancer and Leukemia Group B Study 8083.

1998 • 119 citations

Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene.

1990 • 119 citations

myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens.

1991 • 103 citations

Expression of bcl-2 — protein in small cell lung cancer

1996 • 103 citations

Angiogenesis and non-small cell lung cancer

2000 • 103 citations

Matrix metalloproteinase inhibitors: A novel class of anticancer agents

1995 • 98 citations

Surface ruffles as markers for studies of cell transformation by Rous sarcoma virus.

1975 • 98 citations

Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogene.

1993 • 95 citations

Maintenance chemotherapy for small cell lung cancer: a critical review of the literature

1998 • 94 citations

Focal adhesion as a signal transduction organelle

1994 • 93 citations

Three distinct regions involved in 3P deletion in human lung cancer.

1993 • 92 citations

Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility

1999 • 92 citations

[A phase II study of CPT-11, a camptothecin derivative, in patients with primary lung cancer. CPT-11 Cooperative Study Group].

1991 • 91 citations

Evidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors

1987 • 89 citations

Profiling the Downstream Genes of Tumor Suppressor PTEN in Lung Cancer Cells by Complementary DNA Microarray

2000 • 75 citations

Phase II study of vinorelbine (Navelbine) in previously treated small cell lung cancer patients

1993 • 75 citations

Phase II Study of Vinorelbine in Heavily Previously Treated Small Cell Lung Cancer

1996 • 74 citations

c-Myc in the Controlm of Cell Proliferation and Embryonic Development

1996 • 74 citations

Chromosome alterations in human small cell lung cancer: frequent involvement of 5q.

1992 • 74 citations

Pathology of small-cell lung cancer

2000 • 69 citations

Charles S. Mott prize. Hereditary cancers disclose a class of cancer genes

1989 • 66 citations

c-myc expression correlates with suppression of c-kit protooncogene expression in small cell lung cancer cell lines.

1993 • 64 citations

Surgery in the management of small cell lung cancer

1997 • 63 citations

Pathology of small cell carcinoma of the lung

2003 • 62 citations

Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines

1998 • 62 citations

Organization of the gene encoding transcriptional repressor δEF1 and cross-species conservation of its domains

1996 • 56 citations

Paclitaxel and G-CSF in Previously Untreated Patients With Extensive Stage Small-Cell Lung Cancer

1999 • 54 citations

Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours

1990 • 54 citations

The myc family of oncogenes and their presence and importance in small-cell lung carcinoma and other tumour types.

1993 • 53 citations

Influence of surgical resection before and after chemotherapy on survival in small cell lung cancer

1991 • 52 citations

Results of operation without adjuvant therapy in the treatment of small cell lung cancer

1992 • 52 citations

Evidence for non-covalent clusters of the c-met proto-oncogene product.

1992 • 48 citations

Expression and autoregulation of transforming growth factor β receptor mRNA in small-cell lung cancer cell lines

1996 • 46 citations

Influence of surgical resection prior to chemotherapy on the long-term results in small cell lung cancer. A study of 150 operable patients

1986 • 46 citations

Surgery For Cure Followed By Chemotherapy In Small Cell Carcinoma Of The Lung: For The Isc-Lung Cancer Study Group

1995 • 46 citations

Heterogenous amplification of myc family oncogenes in small cell lung carcinoma

1990 • 44 citations

Survival in small cell lung carcinoma after surgery.

1986 • 44 citations

Molecular Mechanisms of Lung Cancer

1996 • 44 citations

Cytoskeleton-associated proteins of human lung cancer cells.

1983 • 40 citations

A Prospective Analysis of Chemotherapy Following Surgical Resection of Clinical Stage I-II Small-Cell Lung Cancer

1993 • 40 citations

Recent Insights into the Functions of the Retinoblastoma Susceptibility Gene Product

1997 • 39 citations

Carboplatin in the Treatment of Small Cell Lung Cancer

1998 • 38 citations

Multi-Institutional Phase I/II Trial of Paclitaxel, Cisplatin, and Etoposide With Concurrent Radiation for Limited-Stage Small-Cell Lung Carcinoma

2000 • 38 citations

Homozygous deletion and frequent allelic loss of the 21q11.1-q21.1 region including theANA gene in human lung carcinoma

1998 • 38 citations

Imatinib in small cell lung cancer

2003 • 30 citations

Tumour staging and classification in lung cancer summary of the International Symposium

2000 • 28 citations

Prophylactic cranial irradiation in small cell lung cancer — an update☼☼

1995 • 24 citations

Specific Growth Inhibition of Small‐cell Lung Cancer Cells by Adenovirus Vector Expressing Antisense c‐kit Transcripts

1996 • 24 citations

Genetic etiology of lung cancer.

1992 • 23 citations

The Role of Surgical Resection in the Management of Small Cell Carcinoma of the Lung

1986 • 19 citations

Immunophenotype of small cell lung carcinoma: Expression of NKH-1 and transferrin receptor and absence of most myeloid antigens

1988 • 18 citations

p53 tumour-suppressor gene in non-small-cell lung cancer with neoadjuvant therapy

2000 • 15 citations

A phase I study of cisplatin, etoposide, and paclitaxel in small cell lung cancer.

1997 • 13 citations

Lung cancer mortality among males of Catalonia and Spain compared with other European countries between 1975–1977 and 1987–1989

1996 • 12 citations

Paclitaxel, carboplatin, and oral etoposide in the treatment of small cell lung cancer.

1996 • 10 citations

Anti‐insulin‐like growth factor‐I activity of a novel polysulphonated distamycin A derivative in human lung cancer cell lines

1997 • 9 citations

[Surgery in the treatment of metachronous homolateral non-small cell lung cancer].

2001 • 1 citations