Molecular Mechanisms of Lung Cancer

The p53 tumour suppressor gene

1991 • 3,871 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

p53 function and dysfunction

1992 • 1,918 citations

Cancer statistics, 1995

1995 • 1,434 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.

1987 • 487 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

Microsatellite alterations as clonal markers for the detection of human cancer.

1994 • 448 citations

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer

1994 • 403 citations

Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.

1995 • 339 citations

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

1989 • 338 citations

Allele-Specific Chromosome 3p Deletions Occur at an Early Stage in the Pathogenesis of Lung Carcinoma

1995 • 337 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

Absence of p16(INK4) protein is restricted to the subset of lung cancer lines that retains wildtype RB

1995 • 314 citations

Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose

1992 • 282 citations

Heterogeneous DNA damage and repair in the mammalian genome.

1987 • 274 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung.

1992 • 254 citations

ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent.

1991 • 249 citations

Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.

1989 • 237 citations

Mutation and altered expression of p16^ in human cancer

1994 • 234 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

Mapping of multiple DNA gains and losses in primary small cell lung carcinomas by comparative genomic hybridization

1994 • 211 citations

p53 Protein accumulates frequently in early bronchial neoplasia

1994 • 211 citations

Mutations in the p16(INK4)/MTS1/CDKN2, p15(INK4B)/MTS2, and p18 genes in primary and metastatic lung cancer

1995 • 208 citations

Three distinct regions involved in 3p deletion in human lung cancer

1993 • 200 citations

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

1992 • 199 citations

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

1993 • 180 citations

p53 mutations in human lung tumors.

1992 • 177 citations

Lung cancer: principles and practice

2001 • 175 citations

K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas

1995 • 170 citations

Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.

1992 • 166 citations

Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung.

1994 • 161 citations

Allelotype of non-small cell lung carcinoma - Comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma

1993 • 149 citations

Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancers.

1993 • 147 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence

1991 • 138 citations

Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma.

1994 • 133 citations

Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA)

1993 • 131 citations

p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.

1996 • 130 citations

A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6

1993 • 128 citations

Restoration of the Cellular Senescence Program and Repression of Telomerase by Human Chromosome 3

1995 • 125 citations

Somatic Mutations of the MTS (Multiple Tumor Suppressor) 1/CDK41 (Cyclin-Dependent Kinase-4 Inhibitor) Gene in Human Primary Non-small Cell Lung Carcinomas

1994 • 122 citations

Microsatellite instability and other molecular abnormalities in non-small cell lung cancer

1995 • 117 citations

In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers.

1995 • 115 citations

p53 mutation hotspot in radon-associated lung cancer

1994 • 107 citations

Concurrent p53 expression in bronchial dysplasias and squamous cell lung carcinomas.

1993 • 99 citations

Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.

1994 • 96 citations

KRAS2 as a genetic marker for lung tumor susceptibility in inbred mice

1989 • 95 citations

Molecular mapping of deletion sites in the short arm of chromosome 3 in human lung cancer

1990 • 94 citations

Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.

1992 • 93 citations

Three distinct regions involved in 3P deletion in human lung cancer.

1993 • 92 citations

Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.

1994 • 91 citations

The second intron of the K-ras gene containsregulatory elements associated with mouse lung tumorsusceptibility.

1994 • 86 citations

At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice

1994 • 84 citations

Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer

1995 • 80 citations

The ras/cholesterol connection: implications for ras oncogenicity.

1992 • 78 citations

Relationship of radioactive radon daughters and cigarette smoking in the genesis of lung cancer in uranium miners

1988 • 66 citations

A frequent deletion of chromosome 5q21 in advanced small cell and non-small cell carcinoma of the lung.

1994 • 59 citations

Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors.

1994 • 58 citations

Segregation analysis of smoking‐associated malignancies: Evidence for mendelian inheritance

1994 • 56 citations

Lung cancer histologic types and family history of cancer. Analysis of histologic subtypes of 872 patients with primary lung cancer

1993 • 56 citations

Human non‐small cell lung cancer: P53 protein accumulation is an early event and persists during metastatic progression

1994 • 55 citations

p53 and K-ras in radon-associated lung adenocarcinoma

1996 • 54 citations

Assignment of a locus for mouse lung tumor susceptibility to proximal Chromosome 19

1994 • 54 citations

Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility

1995 • 53 citations

High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J×BALB/cJ) mice

1995 • 40 citations

Involvement of the RAFI locus, at band 3p25, in the 3p deletion of small‐cell lung cancer

1991 • 37 citations

Homozygous deletions at chromosome 9p21 and mutation analysis of p16 and p15 in microdissected primary non-small cell lung cancers

1995 • 32 citations

Famesylamine: An inhibitor of famesylation and growth ofras‐transformed cells

1993 • 27 citations

ONCOGENES AND GROWTH FACTORS IN HUMAN LUNG CANCER

1993 • 22 citations

A frequent deletion of chromosome 5q21 in advanced small cell and non-small cell carcinoma of the lung

1994 • 17 citations

PCR assay for a polymorphic Taql site in the human K-ras-2 gene on chromosome 12p (KRAS2)

1991 • 4 citations

Primers for detection of Stul and BstXI polymorphisms in a fragment co-amplified with c-Ki-ras 2 (KRAS2)

1991 • 4 citations