Expression and Prognostic Significance of Metalloproteinases and Their Tissue Inhibitors in Patients With Small-Cell Lung Cancer

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Changing views of the role of matrix metalloproteinases in metastasis

1997 • 1,585 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum

1992 • 705 citations

Matrix metalloproteinase inhibitors

1997 • 509 citations

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.

1993 • 428 citations

Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma

1996 • 299 citations

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions

1993 • 270 citations

Activation of the precursor of gelatinase A/72 kda type IV collagenase/MMP‐2 in lung carcinomas correlates with the expression of membrane‐type matrix metalloproteinase (MT‐MMP) and with lymph node metastasis

1995 • 267 citations

Type IV collagenases in invasive tumors

1993 • 256 citations

Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies.

1997 • 241 citations

Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2.

1996 • 232 citations

Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.

1993 • 222 citations

Prognostic factors in small cell lung cancer: Multivariate model based on 778 patients treated with chemotherapy with or without irradiation

1987 • 218 citations

Metalloproteinases in tumor progression: the contribution of MMP-9.

1994 • 209 citations

Prediction of colorectal cancer relapse and survival via tissue RNA levels of matrix metalloproteinase-9.

1996 • 193 citations

Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor

1995 • 192 citations

Prognostic significance of laboratory parameters measured at diagnosis in small cell carcinoma of the lung

1986 • 176 citations

Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas

1992 • 143 citations

Analysis of prognostic factors in 766 patients with small cell lung cancer (SCLC): The role of sex as a predictor for survival

1991 • 139 citations

Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: An immunohistochemical study

1997 • 139 citations

Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans

1996 • 133 citations

Expression of matrix metalloproteinases and their inhibitors in human bronchopulmonary carcinomas: Quantificative and morphological analyses

1997 • 133 citations

Matrix metalloproteinase 9 expression in primary human prostatic adenocarcinoma and benign prostatic hyperplasia

1994 • 130 citations

Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.

1992 • 129 citations

Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung

1997 • 121 citations

TIMP1 and adverse prognosis in non-small cell lung cancer.

1996 • 115 citations

Prognostic implications of stage of disease and sites of metastases in patients with small cell carcinoma of the lung treated with intensive combination chemotherapy.

1981 • 114 citations

Stromelysin-3 gene expression in human cancer: an overview.

1994 • 104 citations

Characterization of Gelatinases Linked to Extracellular Matrix Invasion in Ovarian Adenocarcinoma: Purification of Matrix Metalloproteinase 2

1996 • 85 citations

Prognostic factors in small cell carcinoma of the lung: a cancer and leukemia group B study.

1981 • 61 citations

Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma.

1997 • 47 citations

Expression of Type IV Collagen and Its Degrading Enzymes in Squamous Cell Carcinoma of Lung

1994 • 41 citations

Small Cell Lung Cancer: Analysis of Factors Influencing the Response to Treatment and Survival

1994 • 23 citations

Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells

1988 • 6 citations