Superoxide dismutase as a target for the selective killing of cancer cells

Free radicals in biology and medicine

1991 • 17,840 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

The Anthracycline Antineoplastic Drugs

1981 • 794 citations

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1994 • 743 citations

A highly sensitive fluorescent micro-assay of H2O2 release from activated human leukocytes using a dihydroxyphenoxazine derivative

1997 • 496 citations

Copper- and zinc-containing superoxide dismutase, manganese-containing superoxide dismutase, catalase, and glutathione peroxidase in normal and neoplastic human cell lines and normal human tissues.

1982 • 490 citations

Free radicals in biology and medicine

1985 • 416 citations

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

1994 • 400 citations

Spectrophotometric Assay for Superoxide Dismutase Based on Tetrazolium Salt 3′-{1-[(Phenylamino)-carbonyl]-3,4-tetrazolium}-bis(4-methoxy-6-nitro)benzenesulfonic Acid Hydrate Reduction by Xanthine–Xanthine Oxidase

1997 • 329 citations

Manganese Superoxide Dismutase Mediates the Early Release of Mitochondrial Cytochrome C and Subsequent DNA Fragmentation after Permanent Focal Cerebral Ischemia in Mice

1999 • 315 citations

Modification of DNA bases in mammalian chromatin by radiation-generated free radicals

1990 • 255 citations

Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues

1975 • 250 citations

Superoxide-dependent formation of hydroxyl radicals and lipid peroxidation in the presence of iron salts. Detection of ‘catalytic’ iron and anti-oxidant activity in extracellular fluids

1982 • 216 citations

Termination of DNA synthesis by 9-beta-D-arabinofuranosyl-2-fluoroadenine. A mechanism for cytotoxicity.

1990 • 207 citations

Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogs of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol That Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site

1995 • 185 citations

Redox Gene Therapy Protects Human IB-3 Lung Epithelial Cells Against Ionizing Radiation-Induced Apoptosis

1998 • 125 citations

Superoxide anion inhibits drug‐induced tumor cell death

1999 • 91 citations

Superinduction of wild-type p53 protein after 2-methoxyestradiol treatment of Ad5p53-transduced cells induces tumor cell apoptosis

1998 • 68 citations

Kinetic study of O2− dismutation by bovine superoxide dismutase. Evidence for saturation of the catalytic sites by O2−

1975 • 56 citations

Bleomycin A2: a ferrous oxidase.

1979 • 44 citations

Oxygen Insensitivity of the Histochemical Assay of Glucose-6-Phosphate Dehydrogenase Activity for the Discrimination Between Nonmalignant and Malignant Cells

1999 • 21 citations

In Vivo Experimental Studies on the Role of Free Radicals in Photodynamic Therapy. I. Measurement of the Steady State Concentration of Free Radicals in Tumor Tissues of Mice

1993 • 19 citations

In VivoExperimental Studies on the Role of Free Radicals in Photodynamic Therapy

1997 • 17 citations

DNA strand scission by enzymatically reduced mitomycin C: evidence for participation of the hydroxyl radical in the DNA damage.

1985 • 9 citations