CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

WHO Handbook for Reporting Results of Cancer Treatment

1982 • 2,214 citations

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

1966 • 2,159 citations

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer.

1992 • 438 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

Phase I Study of Weekly Intravenous Infusions of CPT-11, a New Derivative of Camptothecin, in the Treatment of Advanced Non-Small-Cell Lung Cancer

1991 • 275 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Small cell lung cancer 1973–1983: Early progress and recent obstacles

1984 • 219 citations

Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin

1971 • 213 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

Action of camptothecin on mammalian cells in culture.

1972 • 190 citations

Etoposide (VP-16) and cisplatin: an effective treatment for relapse in small-cell lung cancer.

1985 • 188 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

Long-term Survival and Toxicity in Small Cell Lung Cancer

1991 • 115 citations

Intensive weekly chemotherapy for the treatment of extensive-stage small-cell lung cancer.

1991 • 112 citations

Patients with Small-Cell Lung Cancer Treated with Combination Chemotherapy with or without Irradiation

1985 • 111 citations

Inhibition of spontaneous and experimental metastasis by a new derivative of camptothecin, CPT-11, in mice

1988 • 87 citations

Long-term Survival in Small Cell Carcinoma of the Lung

1980 • 81 citations

Cisplatin and etoposide combination chemotherapy for refractory small cell carcinoma of the lung

1986 • 72 citations

Plasma camptothecin (NSC-100880) levels during a 5-day course of treatment: relation to dose and toxicity.

1972 • 68 citations

[Phase I clinical study of CPT-11. Research group of CPT-11].

1990 • 65 citations

Small cell carcinoma of the lung. A progress report of 15 years' experience

1987 • 61 citations

Lethal activity of camptothecin sodium on human lymphoma cells.

1974 • 54 citations

Etoposide and cisplatin salvage chemotherapy for small cell lung cancer

1985 • 38 citations

Long-term survival five years or more after combination chemotherapy and radiotherapy for small cell lung carcinoma

1981 • 29 citations

Identification of new drugs in small cell lung cancer: phase II agents first?

1987 • 23 citations

CODE Chemotherapy with or without Recombinant Human Granulocyte Colony-Stimulating Factor in Extensive-Stage Small Cell Lung Cancer

1992 • 21 citations

Evaluation of high-dose etoposide combined with cisplatin for treating relapsed small cell lung cancer

1990 • 20 citations

Chemotherapeutic Results in Small Cell Lung Cancer

1985 • 19 citations

Combination chemotherapy with or without radiation therapy in small cell lung cancer. An analysis of a 5-year follow-up

1990 • 16 citations

Evaluating new drugs in patients with chemosensitive tumours: ethical dilemmas in extensive small cell lung cancer

1989 • 13 citations