Regulation of Lck activity by CD4 and CD28 in the immunological synapse

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

The Immunological Synapse

2001 • 987 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Crystal Structures of c-Src Reveal Features of Its Autoinhibitory Mechanism

1999 • 850 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

T cell antigen receptor activation pathways: The tyrosine kinase connection

1991 • 442 citations

Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor

1999 • 428 citations

Dynamic Coupling between the SH2 and SH3 Domains of c-Src and Hck Underlies Their Inactivation by C-Terminal Tyrosine Phosphorylation

2001 • 386 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands.

1996 • 208 citations

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor.

1993 • 202 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

1999 • 180 citations

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.

1992 • 173 citations

Alterations of the Lymphocyte-Specific Protein Tyrosine Kinase (p56^lck) during T-Cell Activation

1988 • 169 citations

Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site.

1990 • 158 citations

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function

2000 • 155 citations

Information transfer at the immunological synapse

2000 • 141 citations

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1998 • 119 citations

Reciprocal Regulation of Hck Activity by Phosphorylation of Tyr527 and Tyr416

2000 • 113 citations

The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.

1994 • 106 citations

Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes.

1989 • 103 citations

The TCR Triggering Puzzle

2001 • 96 citations

Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation.

1988 • 94 citations

Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.

1992 • 91 citations

DNA topoisomerase IIα interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

2000 • 89 citations

Coordinate Regulation of T Cell Activation by CD2 and CD28

2000 • 82 citations

The lymphocyte‐specific protein tyrosine kinase p56^lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2

1989 • 80 citations

Signal Transduction by CD28 Costimulatory Receptor on T Cells

1996 • 77 citations

The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation.

1990 • 73 citations

Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines.

1995 • 72 citations

Anti-CD3 and phorbol ester induce distinct phosphorylated sites in the SH2 domain of p56lck.

1993 • 54 citations

T cell receptor-mediated signs and signals governing T cell development

1999 • 48 citations

Interaction of CD4:lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase

1992 • 47 citations

Differential Requirements for CD4 in TCR-Ligand Interactions

1999 • 37 citations

Monomeric Class I Molecules Mediate TCR/CD3ε/CD8 Interaction on the Surface of T Cells

2001 • 34 citations

CD28 and T cell co-stimulation.

2000 • 26 citations

Molecular Analysis of the Interaction of p56lck with the CD4 and CD8 Antigens

1991 • 20 citations

EFFECT OF INTRODUCING A HIGH AFFINITY INTRAMOLECULAR SH2 LIGAND

2000 • 19 citations

Interactions of TCR tyrosine based activation motifs with tyrosine kinases

1995 • 19 citations