Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Toll-like receptors in the induction of the innate immune response

2000 • 3,052 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

A family of human receptors structurally related to Drosophila Toll

1998 • 1,735 citations

Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

1999 • 1,714 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

2000 • 1,173 citations

Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

1997 • 969 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP–Independent Mechanism

1997 • 820 citations

IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

1999 • 812 citations

Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide

1998 • 778 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

The Toll-receptor family and control of innate immunity

1999 • 666 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 • 581 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Phosphoinositide kinases

1996 • 529 citations

The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products

2000 • 484 citations

Multiple signals converging on NF-κB

1999 • 483 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Bridging the Gap: Composition, Regulation, and Physiological Function of the IκB Kinase Complex

1999 • 324 citations

Requirement of CDC42 for Salmonella -Induced Cytoskeletal and Nuclear Responses

1996 • 303 citations

Identification of a Central Phosphorylation Site in p21-activated Kinase Regulating Autoinhibition and Kinase Activity

1999 • 245 citations

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

2000 • 238 citations

Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases

1998 • 233 citations

Phosphatidylinositol 3-Kinase in Interleukin 1 Signaling

1997 • 231 citations

Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit

1997 • 208 citations

TAK1 mediates an activation signal from toll‐like receptor(s) to nuclear factor‐κB in lipopolysaccharide‐stimulated macrophages

2000 • 188 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

Activation of the small GTPase Cdc42 by the inflammatory cytokines TNFα and IL-1, and by the Epstein-Barr virus transforming protein LMP1

1999 • 146 citations

The IL-1 receptor and Rho directly associate to drive cell activation in inflammation

1999 • 139 citations

Activation of Phosphatidylinositol 3-Kinase, Protein Kinase B, and p70 S6 Kinases in Lipopolysaccharide-Stimulated Raw 264.7 Cells: Differential Effects of Rapamycin, Ly294002, and Wortmannin on Nitric Oxide Production

1998 • 129 citations

Phagocytosis of Gram-negative bacteria by a unique CD14-dependent mechanism

1997 • 119 citations

Rac1 Regulates Interleukin 1-induced Nuclear Factor κB Activation in an Inhibitory Protein κBα-independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression

2000 • 86 citations

Rac1 and Cdc42 Are Required for Phagocytosis, but Not NF-κB-dependent Gene Expression, in Macrophages Challenged with Pseudomonas aeruginosa

2000 • 59 citations

Activation of NF‐κB in human neutrophils during phagocytosis of bacteria independently of oxidant generation

1998 • 19 citations