The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer

1996 • 1,462 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

1996 • 828 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span

1998 • 566 citations

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1998 • 531 citations

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

1997 • 505 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

1997 • 377 citations

Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction

1999 • 288 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo

1996 • 226 citations

The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells

1998 • 226 citations

PtdIns-3,4,5-P3

1998 • 220 citations

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling

1998 • 212 citations

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

1992 • 212 citations

Molecular mechanisms in B cell antigen receptor signaling

1997 • 194 citations

Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase

1997 • 184 citations

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha ) promoted by hyperosmotic stress

1998 • 175 citations

Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes.

1992 • 128 citations

Recruitment and Phosphorylation of SH2-Containing Inositol Phosphatase and Shc to the B-Cell Fcϒ Immunoreceptor Tyrosine-Based Inhibition Motif Peptide Motif

1997 • 122 citations

FcγRIIB1 Inhibition of BCR-Mediated Phosphoinositide Hydrolysis and Ca2+ Mobilization Is Integrated by CD19 Dephosphorylation

1997 • 121 citations

Thymic lymphoma induction by the AKT8 murine retrovirus.

1988 • 100 citations

Regulation through inhibitory receptors: Lessons from natural killer cells

1997 • 76 citations

Role of the inositol phosphatase SHIP in B cell receptor-induced Ca2+ oscillatory response.

1998 • 75 citations

Cutting Edge: Role of the Inositol Phosphatase SHIP in B Cell Receptor-Induced Ca2+ Oscillatory Response

1998 • 66 citations

FcγRIIb Modulation of Surface Immunoglobulin-induced Akt Activation in Murine B Cells

1999 • 64 citations

The Itk/Btk/Tec Family of Protein-Tyrosine Kinases

1994 • 26 citations

The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors

1994 • 25 citations