CD19 Function in Early and Late B Cell Development: I. Maintenance of Follicular and Marginal Zone B Cells Requires CD19-Dependent Survival Signals

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

1999 • 843 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes

1992 • 673 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation

2001 • 548 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response

2000 • 537 citations

Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex

2000 • 513 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Most peripheral B cells in mice are ligand selected.

1991 • 424 citations

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.

1993 • 413 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

1992 • 400 citations

IgMhighCD21high Lymphocytes Enriched in the Splenic Marginal Zone Generate Effector Cells More Rapidly Than the Bulk of Follicular B Cells

1999 • 364 citations

Transitional B cells are the target of negative selection in the B cell compartment.

1995 • 352 citations

Positive Selection from Newly Formed to Marginal Zone B Cells Depends on the Rate of Clonal Production, CD19, and btk

2000 • 349 citations

Memory B-cell persistence is independent of persisting immunizing antigen

2000 • 345 citations

The Follicular versus Marginal Zone B Lymphocyte Cell Fate Decision Is Regulated by Aiolos, Btk, and CD21

2001 • 335 citations

Homeostasis of Peripheral B Cells in the Absence of B Cell Influx from the Bone Marrow

2001 • 313 citations

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

1991 • 301 citations

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

1995 • 279 citations

Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7−/− Mice

2001 • 271 citations

Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity

1998 • 267 citations

Role of antigen receptor affinity in T cell–independent antibody responses in vivo

2002 • 263 citations

bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells

2000 • 220 citations

The CD19/CD21 Complex Functions to Prolong B Cell Antigen Receptor Signaling from Lipid Rafts

2001 • 215 citations

Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily.

1989 • 195 citations

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1996 • 178 citations

The Role of the CD19/CD21 Complex in B Cell Processing and Presentation of Complement-Tagged Antigens

2001 • 174 citations

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

2000 • 164 citations

Nuclear Factor κb Is Required for the Development of Marginal Zone B Lymphocytes

2000 • 160 citations

A B-cell receptor-specific selection step governs immature to mature B cell differentiation

2000 • 159 citations

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.

1995 • 158 citations

Protective T Cell–Independent Antiviral Antibody Responses Are Dependent on Complement

1999 • 155 citations

Germinal centers: form and function

1998 • 132 citations

Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton’s Tyrosine Kinase

1999 • 126 citations

CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.

1988 • 124 citations

Frequent Aberrant Immunoglobulin Gene Rearrangements in Pro-B Cells Revealed by a bcl-x Transgene

1996 • 120 citations

CD19-dependent Activation of Akt Kinase in B-lymphocytes

2001 • 116 citations

Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny.

1993 • 115 citations

The signaling activity of murine CD19 is regulated during cell development.

1996 • 104 citations

Cutting Edge Commentary: Origins of B-1 Cells

2001 • 93 citations

CD1high B cells: a population of mixed origin

1999 • 86 citations

B cell life span: A review

1997 • 86 citations

Tyrosine phosphorylation of CD19 in pre-B and mature B cells.

1993 • 84 citations

Long-Lived B Cells Are Distinguished by Elevated Expression of A1

1998 • 72 citations

Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19

1998 • 71 citations

CD19 Can Regulate B Lymphocyte Signal Transduction Independent of Complement Activation

2001 • 62 citations

B‐cell antigen receptor competence regulates B‐lymphocyte selection and survival

2000 • 53 citations

Cutting Edge: Recruitment of the CD19/CD21 Coreceptor to B Cell Antigen Receptor Is Required for Antigen-Mediated Expression of Bcl-2 by Resting and Cycling Hen Egg Lysozyme Transgenic B Cells

1999 • 51 citations

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase

2000 • 42 citations

Impaired CD40‐Signalling in CD19‐Deficient Mice Selectively Affects Th2‐Dependent Isotype Switching

2001 • 22 citations

Differential induction of DNA-binding activities following CD19 cross-linking in human B lineage cells.

1997 • 16 citations