In situdetection of activated Bruton’s tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

1996 • 444 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively down-regulated in T lymphocytes and plasma cells.

1994 • 301 citations

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production

1998 • 249 citations

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen

1998 • 242 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity

1996 • 203 citations

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

1994 • 196 citations

Molecular mechanisms in B cell antigen receptor signaling

1997 • 194 citations

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

1997 • 192 citations

Activation of bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

1995 • 191 citations

B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia.

1994 • 187 citations

Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit

1997 • 186 citations

Btk function in B cell development and response

1998 • 181 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

Transphosphorylation of Bruton's Tyrosine Kinase on Tyrosine 551 Is Critical for B Cell Antigen Receptor Function

1997 • 129 citations

Phosphorylation of two regulatory tyrosine residues in the activation of Bruton’s tyrosine kinase via alternative receptors

1997 • 129 citations

Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.

1995 • 127 citations

The Tec29 Tyrosine Kinase Is Required during Drosophila Embryogenesis and Interacts with Src64 in Ring Canal Development

1998 • 104 citations

Btk dosage determines sensitivity to B cell antigen receptor cross-linking

1997 • 103 citations

CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction

1995 • 87 citations

SRC64 Regulates the Localization of a Tec-Family Kinase Required for Drosophila Ring Canal Growth

1998 • 80 citations

Independent and Opposing Roles For Btk and Lyn in B and Myeloid Signaling Pathways

1998 • 74 citations

Constitutive membrane association potentiates activation of Bruton tyrosine kinase

1997 • 73 citations

Analysis of signaling via surface immunoglobulin receptors on b cells from cba/n mice

1989 • 70 citations

Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase

1998 • 66 citations

B cells from CBA/N mice do not proliferate following ligation of CD40

1994 • 55 citations

Defective IL-5-receptor-mediated signaling in B cells of X-linked immunodeficient mice

1995 • 52 citations

Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene

1998 • 38 citations

Phosphatidylinositol-3-kinase activity is required for the anti-ig- mediated growth inhibition of a human B-lymphoma cell line

1996 • 32 citations