Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function

1996 • 229 citations

Regulation of Colony-Stimulating Factor 1 Receptor Signaling by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1996 • 199 citations

Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product.

1994 • 198 citations

SH3 Domains: Minding your p's and q's

1995 • 197 citations

CD28 signals through acidic sphingomyelinase.

1995 • 194 citations

The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120

1995 • 186 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras.

1994 • 169 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21^ras

1995 • 155 citations

Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.

1994 • 125 citations

The Tyrosine Phosphatase PTP1C Associates with Vav, Grb2, and mSos1 in Hematopoietic Cells

1996 • 124 citations

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

1995 • 124 citations

CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase

1994 • 102 citations

Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 100 citations

Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.

1996 • 87 citations

The T-Cell Antigen CD5 Acts as a Receptor and Substrate for the Protein-Tyrosine Kinase p56^lck

1994 • 81 citations

Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.

1994 • 81 citations

Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK

1996 • 77 citations

Sphingomyelin‐ceramide turnover in CD28 costimulatory signaling

1995 • 66 citations

Activation of src Family Kinase lck Following CD28 Crosslinking in the Jurkat Leukemic Cell Line

1994 • 59 citations

The proline-rich region of Vav binds to Grb2 and Grb3-3.

1995 • 49 citations

Cross‐linking CD28 leads to activation of 70‐kDa S6 kinase

1994 • 37 citations

CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase: common co-signals induced by CD80 and CD86

1996 • 28 citations

Involvement of Src‐homology‐2‐domain‐containing Protein‐tyrosine Phosphatase 2 in T Cell Activation

1996 • 24 citations