Regulating protein degradation by ubiquitination

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

1995 • 885 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Mitosis in transition

1994 • 745 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway

1996 • 704 citations

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

1978 • 622 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7

1994 • 520 citations

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1995 • 492 citations

The N-end rule

1992 • 464 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

A new foreign policy: MHC class I molecules monitor the outside world

1996 • 422 citations

Ubiquitin-Mediated Pathways for Intracellular Proteolysis

1987 • 409 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification

1996 • 402 citations

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor

1993 • 397 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.

1993 • 377 citations

Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme

1996 • 365 citations

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

1996 • 365 citations

Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the drosophila genome

1982 • 362 citations

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

1993 • 326 citations

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

1994 • 319 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

Cell Surface Molecule Associated with Lymphocyte Homing Is a Ubiquitinated Branched-Chain Glycoprotein

1986 • 312 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway

1996 • 306 citations

Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T

1995 • 292 citations

p62, a Phosphotyrosine-independent Ligand of the SH2 Domain of p56 , Belongs to a New Class of Ubiquitin-binding Proteins

1996 • 289 citations

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway.

1994 • 274 citations

Protein Degradation in Plants

1993 • 273 citations

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1996 • 273 citations

Regulated degradation of the transcription factor Gcn4.

1994 • 271 citations

Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression.

1985 • 264 citations

Control of Cell Fate by a Deubiquitinating Enzyme Encoded by the fat facets Gene

1995 • 262 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

The Gap Junction Protein Connexin43 Is Degraded via the Ubiquitin Proteasome Pathway

1995 • 253 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

A Deubiquitinating Enzyme Interacts with SIR4 and Regulates Silencing in S. cerevisiae

1996 • 228 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

Primary structures of two homologous subunits of PA28, a γ‐interferon‐inducible protein activator of the 20S proteasome

1995 • 196 citations

Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma.

1996 • 195 citations

Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases

1995 • 194 citations

Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α

1996 • 182 citations

Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease.

1994 • 175 citations

PA28 Activator Protein Forms Regulatory Caps on Proteasome Stacked Rings

1994 • 167 citations

Degradation of the Proto-Oncogene Product c-Fos by the Ubiquitin Proteolytic System In Vivo and In Vitro: Identification and Characterization of the Conjugating Enzymes

1995 • 167 citations

Ubiquitination of Protein Kinase C-α and Degradation by the Proteasome

1996 • 161 citations

Degradation of G alpha by the N-end rule pathway

1994 • 154 citations

Cloning of Human Ubiquitin-conjugating Enzymes UbcH6 and UbcH7 (E2-F1) and Characterization of Their Interaction with E6-AP and RSP5

1996 • 151 citations

Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105

1995 • 150 citations

Roles of Ubiquitinylation in Proteolysis and Cellular Regulation

1995 • 150 citations

The ‘second-codon rule’ and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes.

1992 • 147 citations

Degradation of c-Fos by the 26S Proteasome Is Accelerated by c-Jun and Multiple Protein Kinases

1995 • 140 citations

Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation.

1995 • 140 citations

Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway

1995 • 139 citations

The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes

1993 • 134 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Stepwise Movement of Preproteins in the Process of Translocation across the Cytoplasmic Membrane of Escherichia coli

1995 • 126 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

Coordinated Induction of the Ubiquitin Conjugation Pathway Accompanies the Developmentally Programmed Death of Insect Skeletal Muscle

1995 • 124 citations

Ubiquitin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis.

1993 • 124 citations

The Transmembrane Domain of a Carboxyl-terminal Anchored Protein Determines Localization to the Endoplasmic Reticulum

1997 • 122 citations

Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.

1993 • 119 citations

Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells

1994 • 119 citations

Identification of a Family of Closely Related Human Ubiquitin Conjugating Enzymes

1995 • 119 citations

Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25.

1996 • 110 citations

Targeted Degradation of c-Fos, But Not v-Fos, by a Phosphorylation-Dependent Signal on c-Jun

1992 • 110 citations

Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.

1993 • 102 citations

The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins

1991 • 101 citations

Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.

1994 • 95 citations

Ubiquitination of the Rat Uterine Estrogen Receptor: Dependence on Estradiol

1995 • 95 citations

Identification of a Novel Family of Ubiquitin-conjugating Enzymes with Distinct Amino-terminal Extensions

1996 • 91 citations

Ubiquitin is attached to membranes of baculovirus particles by a novel type of phospholipid anchor

1995 • 84 citations

T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation

1996 • 83 citations

Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs

1994 • 73 citations

Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles.

1992 • 64 citations

Ligand-Induced Polyubiquitination of Receptor Tyrosine Kinases

1995 • 58 citations

Mos is degraded by the 26S proteasome in a ubiquitin‐dependent fashion

1993 • 56 citations

Inactivation of NF-κB Inhibitor IκBα: Ubiquitin-Dependent Proteolysis and Its Degradation Product

1995 • 53 citations

Degradation of Ornithine Decarboxylase by the Mammalian and Yeast 26S Proteasome Complexes Requires all the Components of the Protease

1995 • 44 citations

Protein ubiquitination is regulated by phosphorylation. An in vitro study.

1992 • 41 citations

Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent

1994 • 40 citations

Isolation, Characterization, and Partial Purification of a Novel Ubiquitin-Protein Ligase, E3

1996 • 38 citations

The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain.

1995 • 36 citations

An essential ubiquitin-conjugating enzyme with tissue and developmental specificity in th nematode Caenorhabditis elegans.

1996 • 26 citations

Ubiquitin-activating enzyme, e1, is phosphorylated in mammalian cells by the protein kinase cdc2

1995 • 16 citations

Induced expression of a ubiquitin COOH-terminal hydrolase in acute lymphoblastic leukemia.

1995 • 12 citations