The Gap Junction Protein Connexin43 Is Degraded via the Ubiquitin Proteasome Pathway

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.

1990 • 697 citations

Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.

1989 • 516 citations

Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes

1991 • 469 citations

The N-end rule

1992 • 464 citations

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

1991 • 345 citations

Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes.

1989 • 341 citations

Five-hour half-life of mouse liver gap-junction protein.

1981 • 323 citations

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants.

1994 • 319 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

CTL induction by a tumour-associated antigen octapeptide derived from a murine lung carcinoma

1994 • 254 citations

Remodeling of ventricular conduction pathways in healed canine infarct border zones.

1991 • 234 citations

Expression of Multiple Connexins in Cultured Neonatal Rat Ventricular Myocytes

1995 • 183 citations

Evidence for the participation of actin microfilaments and bristle coats in the internalization of gap junction membrane.

1979 • 175 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

Modulation of cell junctions during differentiation of the chicken otocyst sensory epithelium

1979 • 168 citations

Degradation of G alpha by the N-end rule pathway

1994 • 154 citations

Ubiquitinylation Is Not an Absolute Requirement for Degradation of c-Jun Protein by the 26 S Proteasome

1995 • 150 citations

The cytoplasmic domain of P-selectin contains a sorting determinant that mediates rapid degradation in lysosomes

1994 • 145 citations

Degradation of Ornithine Decarboxylase in Reticulocyte Lysate Is ATP-dependent but Ubiquitin-independent

1989 • 139 citations

Degradation and resynthesis of gap junction protein in plasma membranes of regenerating liver after partial hepatectomy or cholestasis

1983 • 137 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells

1994 • 119 citations

The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins

1991 • 101 citations

Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2

1994 • 100 citations

Fate of gap junctions in isolated adult mammalian cardiomyocytes.

1989 • 91 citations

Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain

1993 • 89 citations

Molecular and Regulatory Properties of the Adenylyl Cyclase-Coupled β-Adrenergic Receptors

1993 • 88 citations

Characterization of the gap junction protein, connexin45

1994 • 67 citations

Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles.

1992 • 64 citations

The cardiac gap junction protein (Mr 47,000) has a tissue-specific cytoplasmic domain of Mr 17,000 at its carboxy-terminus

1987 • 50 citations

Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells.

1986 • 43 citations

Immunolocalization of ubiquitin conjugates at Z-bands and intercalated discs of rat cardiomyocytes in vitro and in vivo.

1992 • 33 citations

Rescue of the complex temperature-sensitive phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitin-activating enzyme cDNA

1994 • 29 citations