Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Ubiquitination

1991 • 430 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

Degradation of nuclear oncoproteins by the ubiquitin system in vitro.

1991 • 345 citations

The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis.

1982 • 324 citations

"Covalent affinity" purification of ubiquitin-activating enzyme.

1982 • 310 citations

UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme.

1991 • 281 citations

Functional heterogeneity of ubiquitin carrier proteins.

1985 • 281 citations

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

1991 • 246 citations

Epitope-tagged ubiquitin. A new probe for analyzing ubiquitin function.

1991 • 212 citations

Arthrin, a myofibrillar protein of insect flight muscle, is an actin-ubiquitin conjugate

1987 • 210 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

1990 • 184 citations

A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1.

1988 • 173 citations

The ubiquitin pathway for protein degradation

1991 • 170 citations

Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme El

1991 • 156 citations

Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.

1990 • 152 citations

Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock.

1987 • 145 citations

Spermatogenic failure in male mice lacking H–Y antigen

1986 • 142 citations

Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

1991 • 129 citations

A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme E1

1991 • 127 citations

How are substrates recognized by the ubiquitin-mediated proteolytic system

1989 • 125 citations

Ubiquitin-Phytochrome Conjugates

1989 • 103 citations

Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.

1984 • 101 citations

Immunogold electron microscopy of phytochrome in Avena: identification of intracellular sites responsible for phytochrome sequestering and enhanced pelletability.

1986 • 77 citations

Immunoelectron microscopic localization of ubiquitin in hepatoma cells.

1988 • 74 citations

Cloning of ubiquitin activating enzyme from wheat and expression of a functional protein in Escherichia coli.

1990 • 69 citations

Preliminary characterization of the temperature-sensitive defect in DNA replication in a mutant mouse L cell

1976 • 64 citations

Microinjection of ubiquitin: intracellular distribution and metabolism in HeLa cells maintained under normal physiological conditions.

1987 • 64 citations

Molecular cloning, primary structure and expression of the human X linked A1S9 gene cDNA which complements the ts A1S9 mouse L cell defect in DNA replication.

1990 • 61 citations

Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells.

1992 • 56 citations

Cellular content of ubiquitin and formation of ubiquitin conjugates during chicken spermatogenesis

1988 • 46 citations

Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells.

1986 • 43 citations

Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton

1993 • 34 citations

Purification, Characterization, and Rapid Inactivation of Thermolabile Ubiquitin-activating Enzyme from the Mammalian Cell Cycle Mutant ts85

1989 • 28 citations

Characterization of a family of nuclear and chromosomal proteins identified by a monoclonal antibody.

1985 • 21 citations

Degradation of a nuclear-localized protein in mammalian COS cells, using Escherichia coli beta-galactosidase as a model protein.

1992 • 16 citations

Auto-ubiquitination of ubiquitin-activating enzymes from chicken breast muscle

1990 • 16 citations