Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Prevention of Vertebrate Neuronal Death by the crmA Gene

1994 • 618 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Calpain activation in apoptosis

1994 • 445 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress

1995 • 412 citations

Proteasomes: protein degradation machines of the cell

1994 • 320 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain

1994 • 314 citations

Inactivation of Interleukin-1.beta. Converting Enzyme by Peptide (Acyloxy)methyl Ketones

1994 • 267 citations

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

1988 • 254 citations

Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome

1993 • 252 citations

Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex

1992 • 217 citations

A New Inhibitor of the Chymotrypsin‐Like Activity of the Multicatalytic Proteinase Complex (20S Proteasome) Induces Accumulation of Ubiquitin‐Protein Conjugates in a Neuronal Cell

1994 • 183 citations

Cell Death During Development Of The Nervous System

1991 • 168 citations

Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2

1995 • 155 citations

Biochemical characterization of programmed cell death in NGF‐deprived sympathetic neurons

1992 • 146 citations

Role of multiple cellular proteases in the execution of programmed cell death

1995 • 141 citations

Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation.

1995 • 140 citations

[57] Cystatin, the egg white inhibitor of cysteine proteinases

1981 • 124 citations

Neuronal death during development in the isthmo‐optic nucleus of the chick: Sustaining role of afferents from the tectum

1985 • 117 citations

Purification and Characterization of a Z-Leu-Leu-Leu-MCA Degrading Protease Expected to Regulate Neurite Formation: A Novel Catalytic Activity in Proteasome

1993 • 117 citations

Inhibition of degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in vivo by cysteine protease inhibitors

1991 • 109 citations

The Ubiquitin System for Protein Degradation

1992 • 97 citations

Molecular control of life and death

1995 • 95 citations

Changes in the Structure and Function of the Multicatalytic Proteinase (Proteasome) during Programmed Cell Death in the Intersegmental Muscles of the Hawkmoth, Manduca sexta

1995 • 86 citations

Inhibition of cysteine proteinases in lysosomes and whole cells

1992 • 84 citations

Analysis of structure-function relationship of pig calpastatin by expression of mutated cDNAs in Escherichia coli.

1988 • 75 citations

Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.

1993 • 61 citations

Synthetic Inhibitors of the Multicatalytic Proteinase Complex (Proteasome)

1993 • 55 citations

Calpastatins: biochemical and molecular biological studies.

1991 • 36 citations

Interleukin-1 alpha, a major component of fetal calf serum: artifacts in IL-1 bioassays

1989 • 2 citations