Drosophila hedgehog acts as a morphogen in cellular patterning

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

The embryonic development of Drosophila melanogaster

1938 • 2,188 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Embryonic Development and Induction

1939 • 1,175 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1988 • 1,022 citations

Expression of engrailed proteins in arthropods, annelids, and chordates

1989 • 1,019 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Organizing activity of wingless protein in Drosophila

1993 • 852 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

The engrailed locus of drosophila: Structural analysis of an embryonic transcript

1985 • 735 citations

Control of cell pattern in the developing nervous system: Polarizing activity of the floor plate and notochord

1991 • 698 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1990 • 508 citations

decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo

1992 • 480 citations

The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin

1990 • 474 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

1985 • 456 citations

Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communication

1989 • 452 citations

Molecular cloning of sequences from wingless , a segment polarity gene in Drosophila : the spatial distribution of a transcript in embryos

1987 • 437 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts

1985 • 346 citations

Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster

1982 • 345 citations

The embryonic development of Drosophila melanogaster

1986 • 339 citations

Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member

1993 • 320 citations

Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord

1990 • 300 citations

Roles of wingless in patterning the larval epidermis of Drosophila

1991 • 295 citations

A fate map for the larval epidermis ofDrosophila melanogaster: localized cuticle defects following irradiation of the blastoderm with an ultraviolet laser microbeam

1979 • 287 citations

From Egg to Embryo

1983 • 277 citations

Induction of floor plate differentiation by contact-dependent, homeogenetic signals

1993 • 271 citations

Phenocopies induced with antisense RNA identify the wingless gene

1987 • 259 citations

Multiple modes of engrailed regulation in the progression towards cell fate determination

1991 • 248 citations

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

1992 • 248 citations

Secretion and movement of wingless protein in the epidermis of the Drosophila embryo

1991 • 244 citations

Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter.

1990 • 241 citations

Borders of parasegments in Drosophila embryos are delimited by the fushi tarazu and even-skipped genes

1987 • 230 citations

Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila

1988 • 228 citations

Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo

1992 • 222 citations

The number of polarizing region cells required to specify additional digits in the developing chick wing

1981 • 209 citations

Altering the insertional specificity of a Drosophila transposable element.

1992 • 198 citations

Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.

1988 • 190 citations

Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched

1990 • 182 citations

Gradients in the Insect Segment: The Orientation of Hairs in the Milkweed Bug Oncopeltus Fasciatus

1966 • 178 citations

The state of engrailed expression is not clonally transmitted during early Drosophila development

1992 • 173 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos

1993 • 172 citations

Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3

1990 • 161 citations

The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo

1992 • 157 citations

An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily.

1990 • 154 citations

The Cuticular Pattern in An Insect, Rhodnius Prolixus Stål

1959 • 152 citations

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

1990 • 151 citations

Regulation of wingless transcription in the Drososphila embryo

1993 • 135 citations

Drosophila wingless generates cell type diversity among engrailed expressing cells

1992 • 116 citations

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

1993 • 112 citations

Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo.

1988 • 107 citations

Embryonic Development and Induction

1939 • 70 citations

The Cuticular Pattern in an Insect—The Intersegmental Membranes

1960 • 64 citations

A role for wingless in the segmental gradient of Drosophila?

1993 • 55 citations

Intercellular signalling in Drosophila segment formation reconstructed in vitro

1993 • 50 citations

Further Studies on Gradient-Dependent Diversification in the Pupal Cuticle of Galleria Mellonella

1968 • 44 citations

Cell and cubitus interruptus Dominant: Two segment polarity genes on the fourth chromosome in Drosophila

1987 • 40 citations

A cellular basis for pattern formation in the insect epidermis

1989 • 39 citations

Pattern stability in the insect segment

1979 • 38 citations

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