Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Synthesis and Processing of Asparagine-Linked Oligosaccharides

1981 • 1,403 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Wnt genes

1992 • 799 citations

Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization

1993 • 777 citations

Chemotropic guidance of developing axons in the mammalian central nervous system

1988 • 681 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

1994 • 594 citations

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

1992 • 585 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

Autoproteolysis in hedgehog protein biogenesis

1994 • 541 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.

1990 • 478 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

1994 • 451 citations

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 • 451 citations

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1989 • 416 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation.

1992 • 400 citations

The GLI gene is a member of the Kruppel family of zinc finger proteins

1988 • 396 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

A quantitative analysis of the effect of excision of the AER from the chick limb-bud

1974 • 376 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1995 • 315 citations

Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

1993 • 313 citations

Protein kinase A and hedgehog signaling in drosophila limb development

1995 • 310 citations

Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord

1990 • 300 citations

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

1994 • 298 citations

Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb

1996 • 298 citations

ATP-DEPENDENT TRANSPORT SYSTEMS IN BACTERIA AND HUMANS: Relevance to Cystic Fibrosis and Multidrug Resistance

1993 • 290 citations

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1995 • 275 citations

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

1992 • 248 citations

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

1990 • 246 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

1994 • 212 citations

A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog

1995 • 198 citations

patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets

1995 • 185 citations

Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched

1990 • 182 citations

Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate

1991 • 177 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

Genetic analysis of hedgehog signalling in the Drosophila embryo

1993 • 167 citations

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning

1995 • 160 citations

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

1995 • 145 citations

Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A

1995 • 117 citations

Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo

1993 • 112 citations

Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

1994 • 111 citations

Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.

1995 • 103 citations

Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity

1995 • 97 citations

patched Overexpression Causes Loss of wingless Expression in Drosophila Embryos

1994 • 32 citations

Unrestricted expression of the Drosophila gene patched allows a normal segment polarity

1991 • 30 citations

Convergence and divergence in the evolution of transport proteins

1994 • 29 citations

Deleted Work

1955 • 0 citations