Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.

Stages of embryonic development of the zebrafish

1995 • 11,263 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

1993 • 1,086 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

1994 • 869 citations

Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein

1994 • 842 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate

1994 • 762 citations

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 • 664 citations

Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos

1996 • 653 citations

no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene

1994 • 628 citations

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 • 624 citations

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain

1995 • 557 citations

Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube

1995 • 542 citations

Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.

1995 • 504 citations

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

1995 • 491 citations

Induction of midbrain dopaminergic neurons by Sonic hedgehog

1995 • 481 citations

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

1993 • 470 citations

Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites

1994 • 451 citations

Midline signalling is required for Pax gene regulation and patterning of the eyes

1995 • 433 citations

The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system

1991 • 432 citations

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye

1993 • 423 citations

The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina

1993 • 414 citations

Role of the Drosophila patched gene in positional signalling

1991 • 414 citations

Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

1995 • 376 citations

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

1995 • 341 citations

Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development

1995 • 315 citations

Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

1993 • 313 citations

Protein kinase A and hedgehog signaling in drosophila limb development

1995 • 310 citations

Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog

1995 • 309 citations

Products, genetic linkage and limb patterning activity of a murine hedgehog gene

1994 • 298 citations

Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish

1995 • 290 citations

Expression pattern of zebrafish pax genes suggests a role in early brain regionalization

1991 • 255 citations

Zebrafish primary neurons initiate expression of the LIM homeodomain protein Isl-1 at the end of gastrulation

1993 • 252 citations

Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

1987 • 248 citations

Developmental regulation of Islet‐1 mRNA expression during neuronal differentiation in embryonic zebrafish

1994 • 236 citations

cAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs

1995 • 236 citations

Expression of a type II collagen gene in the zebrafish embryonic axis

1995 • 227 citations

Expression of two zebrafish orthodenticle-related genes in the embryonic brain

1994 • 227 citations

Drosophila hedgehog acts as a morphogen in cellular patterning

1994 • 215 citations

Diversity of expression of engrailed-like antigens in zebrafish

1991 • 211 citations

Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis

1995 • 200 citations

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

1993 • 172 citations

Genetic analysis of hedgehog signalling in the Drosophila embryo

1993 • 167 citations

Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation

1995 • 165 citations

Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein

1995 • 162 citations

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning

1995 • 160 citations

Hedgehog and beyond

1995 • 149 citations

Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing

1995 • 145 citations

The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation

1993 • 141 citations

Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity.

1992 • 133 citations

Genomic structure and restricted neural expression of the zebrafish wnt-1 (int-1) gene.

1991 • 129 citations

Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A

1995 • 117 citations

Secretion of the amino-terminal fragment of the Hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila

1995 • 76 citations

Somite Differentiation: Sonic signals somites

1995 • 66 citations

Morphogenetic Signalling: Responses to Hedgehog

1995 • 23 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 14 citations