The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Mutations affecting segment number and polarity in Drosophila

1980 • 4,280 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

Genetic variations of Drosophila melanogaster

1967 • 2,612 citations

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

Analysis of membrane and surface protein sequences with the hydrophobic moment plot

1984 • 2,234 citations

The embryonic development of Drosophila melanogaster

1938 • 2,188 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 1,546 citations

The molecular genetics of embryonic pattern formation in Drosophila

1988 • 1,048 citations

Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis

1983 • 1,034 citations

The molecular basis for metameric pattern in the Drosophila embryo

1987 • 1,028 citations

The structure and function of the homeodomain

1989 • 1,007 citations

Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates

1987 • 966 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

The detection and classification of membrane-spanning proteins

1985 • 854 citations

The engrailed locus of drosophila: Structural analysis of an embryonic transcript

1985 • 735 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 671 citations

Determination of Anteroposterior Polarity in Drosophila

1987 • 651 citations

A conformational preference parameter to predict helices in integral membrane proteins

1986 • 565 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 538 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

1986 • 497 citations

Parasegments and compartments in the Drosophila embryo

1985 • 492 citations

Three-dimensional structure of a genetically engineered variant of porcine growth hormone.

1987 • 457 citations

The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

1985 • 456 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Molecular cloning of sequences from wingless , a segment polarity gene in Drosophila : the spatial distribution of a transcript in embryos

1987 • 437 citations

Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein

1985 • 406 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

Spatial distribution of transcripts from the segmentation gene fushi tarazu during Drosophila embryonic development

1984 • 369 citations

Distal Regeneration and Symmetry

1981 • 352 citations

Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts

1985 • 346 citations

Receptor and Antibody Epitopes in Human Growth Hormone Identified by Homolog-Scanning Mutagenesis

1989 • 345 citations

The embryonic development of Drosophila melanogaster

1986 • 339 citations

The molecular organization of the Antennapedia locus of drosophila

1983 • 331 citations

Pattern formation in the imaginal wing disc of Drosophila melanogaster: Fate map, regeneration and duplication

1975 • 326 citations

Transcription pattern of the Drosophila segmentation gene hairy

1985 • 305 citations

Engrailed: a gene controlling compartment and segment formation in Drosophila.

1981 • 289 citations

The segmentation and homeotic gene network in early Drosophila development

1987 • 286 citations

Molecular analysis of the armadillo locus: uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene.

1989 • 284 citations

Germline autonomy of maternal-effect mutations altering the embryonic body pattern of Drosophila

1986 • 244 citations

The role of segment polarity genes during Drosophila neurogenesis.

1989 • 235 citations

Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila

1988 • 228 citations

Activation and repression of transcription by homoeodomain-containing proteins that bind a common site

1988 • 217 citations

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

1987 • 213 citations

Multiple functions of segment polarity genes in Drosophila

1987 • 212 citations

Zygotic lethals with specific maternal effect phenotypes in Drosophila melanogaster. I. Loci on the X chromosome.

1989 • 200 citations

Segmental organisation of the head in the embryo of Drosophila melanogaster

1986 • 198 citations

Spatial distribution of Antennapedia transcripts during Drosophila development.

1983 • 191 citations

Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.

1988 • 190 citations

The development of wingless, a homeotic mutation of Drosophila

1977 • 185 citations

Gradients in the Insect Segment: The Orientation of Hairs in the Milkweed Bug Oncopeltus Fasciatus

1966 • 178 citations

Ecdysone-stimulated RNA synthesis in imaginal discs of Drosophila melanogaster

1976 • 161 citations

The Cuticular Pattern in An Insect, Rhodnius Prolixus Stål

1959 • 152 citations

Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis

1987 • 145 citations

Repression and turnover pattern fushi tarazu RNA in the early Drosophila embryo

1986 • 119 citations

Localization of transcripts from the wingless gene in whole Drosophila embryos

1988 • 111 citations

Expansions and Contractions of the Genetic Map Relative to the Physical Map of Yeast Chromosome III

1988 • 108 citations

Structure of transcripts from the homeotic Antennapedia gene of Drosophila melanogaster: two promoters control the major protein-coding region.

1986 • 107 citations

The cuticle genes of Drosophila: A developmentally regulated gene cluster

1981 • 107 citations

The gooseberry-zipper region of Drosophila : five genes encode different spatially restricted transcripts in the embryo

1987 • 87 citations

Segmental organisation of the tail region in the embryo of Drosophila melanogaster

1987 • 80 citations

Expression of engrailed in the parasegment of Drosophila

1985 • 78 citations

Derivation-dependent Distribution of Insertion Sites for a Drosophila Transposon

1981 • 74 citations

Leg regeneration in the cockroach, Blatella germanica: II. Regeneration from a non-congruent tibial graft/host junction

1976 • 71 citations

Regeneration of the segment boundary in Oncopeltus

1981 • 68 citations

Kinetics of renaturation and self-assembly of intermediates on the pathway of folding of the β2-subunit of Escherichia coli tryptophan-synthetase

1982 • 65 citations

The selection, expression, and organization of a set of head-specific genes in Drosophila

1982 • 53 citations

On the role of the engrailed+ gene in the internal organs of Drosophila.

1984 • 49 citations

A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent drosophila developmental mutants

1985 • 49 citations

The segment polarity gene costal-2 in Drosophila

1987 • 45 citations

Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III.

1988 • 40 citations

Cell and cubitus interruptus Dominant: Two segment polarity genes on the fourth chromosome in Drosophila

1987 • 40 citations

The Jonah genes: A new multigene family in Drosophila melanogaster

1985 • 25 citations

Molecular and Recombinational Mapping of Mutations in the Ace Locus of Drosophila melanogaster

1987 • 19 citations

A selective screen to recover chromosomal deletions and duplications in Drosophila melanogaster.

1988 • 10 citations