Serpentine Proteins Slither into the Wingless and Hedgehog Fields

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

1996 • 1,127 citations

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 • 591 citations

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1996 • 474 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

1994 • 407 citations

The dishevelled protein is modified by wingless signaling in Drosophila.

1995 • 389 citations

A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled

1996 • 369 citations

A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains

1989 • 367 citations

Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus

1996 • 320 citations

A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog

1995 • 198 citations

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

1994 • 194 citations

The genetic basis of patterned baldness in Drosophila

1994 • 182 citations

dishevelled is a component of the frizzled signaling pathway in Drosophila

1995 • 176 citations

Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos

1993 • 172 citations

Hedgehog and beyond

1995 • 149 citations

Signalling by hedgehog family proteins in Drosophila and vertebrate development

1995 • 107 citations