Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies

Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

1999 • 1,042 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1

1999 • 809 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

SUMO—Nonclassical Ubiquitin

2000 • 764 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

1999 • 659 citations

The mRNA 5′ cap-binding protein eIF4E and control of cell growth

1998 • 651 citations

Pml is essential for multiple apoptotic pathways

1998 • 564 citations

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1997 • 528 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Combinatorial Roles of the Nuclear Receptor Corepressor in Transcription and Development

2000 • 502 citations

Cajal Bodies: The First 100 Years

2000 • 493 citations

Role of Promyelocytic Leukemia (Pml) Sumolation in Nuclear Body Formation, 11s Proteasome Recruitment, and as2O3-Induced Pml or Pml/Retinoic Acid Receptor α Degradation

2001 • 477 citations

PML protein isoforms and the RBCC/TRIM motif

2001 • 465 citations

Sequence-Specific Binding of Transfer RNA by Glyceraldehyde-3-Phosphate Dehydrogenase

1993 • 461 citations

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

1992 • 441 citations

Evidence for Proteasome Involvement in Polyglutamine Disease: Localization to Nuclear Inclusions in SCA3/MJD and Suppression of Polyglutamine Aggregation in vitro

1999 • 406 citations

RING domains: master builders of molecular scaffolds?

2000 • 396 citations

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

1996 • 394 citations

PML induces a novel caspase-independent death process

1998 • 384 citations

Coupled Transcription and Translation Within Nuclei of Mammalian Cells

2001 • 379 citations

PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.

1996 • 347 citations

Glyceraldehyde-3-phosphate Dehydrogenase Selectively Binds AU-rich RNA in the NAD+-binding Region (Rossmann Fold)

1995 • 345 citations

The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML.

1995 • 324 citations

SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation

1999 • 305 citations

Visualization of gene activity in living cells

2000 • 305 citations

Review: Properties and Assembly Mechanisms of ND10, PML Bodies, or PODs

2000 • 286 citations

Identification of a novel nuclear domain.

1991 • 285 citations

Role and fate of PML nuclear bodies in response to interferon and viral infections

2001 • 278 citations

Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.

1995 • 268 citations

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

1995 • 268 citations

Promyelocytic Leukemia (Pml) Nuclear Bodies Are Protein Structures That Do Not Accumulate RNA

2000 • 266 citations

A monoclonal antibody recognizing nuclear matrix-associated nuclear bodies

1992 • 258 citations

DNA viruses and viral proteins that interact with PML nuclear bodies

2001 • 245 citations

Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body

1998 • 244 citations

The acute promyelocytic leukaemia-associated PML gene is induced by interferon.

1995 • 228 citations

Cytoplasmic Recruitment of INI1 and PML on Incoming HIV Preintegration Complexes

2001 • 216 citations

Induction of the PML protein by interferons in normal and APL cells.

1995 • 216 citations

A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

1992 • 198 citations

The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site.

1992 • 198 citations

Nuclear structure in normal and Bloom syndrome cells

2000 • 189 citations

PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA

2001 • 184 citations

P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

1999 • 177 citations

Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus

2001 • 174 citations

Structure, Organization, and Dynamics of Promyelocytic Leukemia Protein Nuclear Bodies

1998 • 174 citations

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

1999 • 173 citations

SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements

1998 • 173 citations

PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator

2001 • 167 citations

The Promyelocytic Leukemia Gene Product (PML) Forms Stable Complexes with the Retinoblastoma Protein

1998 • 166 citations

Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome

1996 • 165 citations

PML nuclear bodies are general targets for inflammation and cell proliferation.

1995 • 163 citations

Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.

1992 • 162 citations

An Arenavirus RING (Zinc-Binding) Protein Binds the Oncoprotein Promyelocyte Leukemia Protein (PML) and Relocates PML Nuclear Bodies to the Cytoplasm

1998 • 160 citations

ALT-associated PML bodies are present in viable cells and are enriched in cells in the G2/M phase of the cell cycle

2000 • 156 citations

Functional Interaction of p53 and BLM DNA Helicase in Apoptosis

2001 • 149 citations

Ras mediates translation initiation factor 4E-induced malignant transformation.

1992 • 146 citations

The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number

1997 • 143 citations

Role of PML and PML-RARα in Mad-Mediated Transcriptional Repression

2001 • 143 citations

Nuclear domain 10 (ND10) associated proteins are also present in nuclear bodies and redistribute to hundreds of nuclear sites after stress

1995 • 142 citations

The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E 1 1Edited by D. Draper

2001 • 142 citations

Exclusion of Int-6 from PML Nuclear Bodies by Binding to the HTLV-I Tax Oncoprotein

1996 • 135 citations

PML bodies associate specifically with the MHC gene cluster in interphase nuclei

2001 • 132 citations

Molecular Cloning of a New Interferon-induced PML Nuclear Body-associated Protein

1997 • 132 citations

The PML nuclear bodies: actors or extras?

1999 • 131 citations

Analysis of the Growth and Transformation Suppressor Domains of Promyelocytic Leukemia Gene, PML

1996 • 129 citations

The emerging roles of translation factor eIF4E in the nucleus

2002 • 123 citations

Multifunctional regulatory proteins that control gene expression in both the nucleus and the cytoplasm

2001 • 121 citations

The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner

2000 • 117 citations

In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML.

1996 • 116 citations

Two RING Finger Proteins, the Oncoprotein PML and the Arenavirus Z Protein, Colocalize with the Nuclear Fraction of the Ribosomal P Proteins

1998 • 113 citations

PML-containing nuclear bodies: Their spatial distribution in relation to other nuclear components

1996 • 108 citations

Characterization of a new monoclonal antibody (PG-M3) directed against the aminoterminal portion of the PML gene product: immunocytochemical evidence for high expression of PML proteins on activated macrophages, endothelial cells, and epithelia

1995 • 106 citations

Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis

1998 • 101 citations

The Human Interferon- and Estrogen-Regulated ISG20/HEM45 Gene Product Degrades Single-Stranded RNA and DNA in Vitro

2001 • 100 citations

Self-assembly properties of a model RING domain

2002 • 100 citations

Telomerase Can Inhibit the Recombination-based Pathway of Telomere Maintenance in Human Cells

2001 • 96 citations

The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA

2000 • 94 citations

Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: immunocytochemical evidence for differential distribution during changes in functional states

1993 • 82 citations

Initiation factor eIF-4E of Saccharomyces cerevisiae. Distribution within the cell, binding to mRNA, and consequences of its overproduction.

1994 • 80 citations

The promyelocytic leukemia protein PML has a pro‐apoptotic activity mediated through its RING domain

1997 • 79 citations

Role of the Promyelocytic Leukemia Protein PML in the Interferon Sensitivity of Lymphocytic Choriomeningitis Virus

2001 • 76 citations

Effect of PML and PML-RAR on the transactivation properties and subcellular distribution of steroid hormone receptors.

1995 • 71 citations

Cell death induction by the acute promyelocytic leukemia-specific PML/RARα fusion protein

1997 • 70 citations

p53 Binds Selectively to the 5′ Untranslated Region of cdk4, an RNA Element Necessary and Sufficient for Transforming Growth Factor β- and p53-Mediated Translational Inhibition of cdk4

2000 • 69 citations

Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies

1999 • 64 citations

The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control

1999 • 63 citations

Accumulation and Intranuclear Distribution of Unintegrated Human Immunodeficiency Virus Type 1 DNA

2001 • 61 citations

Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes

2001 • 60 citations

Gamma Interferon and Cadmium Treatments Modulate Eukaryotic Initiation Factor 4E-Dependent mRNA Transport of Cyclin D1 in a PML-Dependent Manner

2002 • 58 citations

Nuclear Domains Enriched in RNA 3′-processing Factors Associate with Coiled Bodies and Histone Genes in a Cell Cycle–dependent Manner

1999 • 56 citations

Characterisation of the PML/RARα Rearrangement Associated with t(15;17) Acute Promyelocytic Leukaemia

1997 • 51 citations

Cell-Cycle Regulation of DNA Damage-Induced Expression of the Suppressor GenePML

1997 • 50 citations

Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase

1998 • 48 citations

Transcriptional Repression by the Promyelocytic Leukemia Protein, PML

1997 • 48 citations

Translational Regulation of Ribonucleotide Reductase by Eukaryotic Initiation Factor 4E Links Protein Synthesis to the Control of DNA Replication

1999 • 47 citations

The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability

2001 • 47 citations

Nuclear Distribution of Prothymosin α and Parathymosin: Evidence That Prothymosin α Is Associated with RNA Synthesis Processing and Parathymosin with Early DNA Replication

2000 • 40 citations

Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1

1999 • 38 citations

Construction of Macromolecular Assemblages in Eukaryotic Processes and their Role in Human Disease: Linking RINGs Together

2000 • 35 citations

The distribution and expression of the Bloom’s syndrome gene product in normal and neoplastic human cells

2001 • 33 citations

Localization of the bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: Comparison with the werner's syndrome helicase

1999 • 33 citations

The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells.

1995 • 33 citations

PML and COP1 – two proteins with much in common

2001 • 23 citations

Exploring (novel) gene expression during retinoid-induced maturation and cell death of acute promyelocytic leukemia

2001 • 13 citations

Immunohistochemical expression and pathogenesis of BLM in the human brain and visceral organs

2001 • 6 citations